Biosimulation in Drug Development

Biosimulation in Drug Development

Editor(s): Martin Bertau, Erik Mosekilde, Hans V. Westerhoff

Published Online: 11 JUL 2008

Print ISBN: 9783527316991

Online ISBN: 9783527622672

DOI: 10.1002/9783527622672

About this Book

This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.
Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions.
Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.

Table of contents

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  1. Part I: Introduction

    1. Chapter 1

      Simulation in Clinical Drug Development (pages 1–26)

      Juan Jose Perez-Ruixo, Filip De Ridder, Hui Kimko, Mahesh Samtani, Eugene Cox, Surya Mohanty and An Vermeulen

    2. Chapter 3

      Biosimulation of Drug Metabolism (pages 59–85)

      Prof. Dr. Martin Bertau, Lutz Brusch and Ursula Kummer

  2. Part II: Simulating Cells and Tissues

    1. Chapter 4

      Correlation Between In Vitro, In Situ, and In Vivo Models (pages 87–113)

      Isabel González-Álvarez, Vicente Casabó, Virginia Merino and Marival Bermejo

    2. Chapter 6

      The Glucose–Insulin Control System (pages 141–196)

      Christine Erikstrup Hallgreen, Thomas Vagn Korsgaard, René Normann Hansen and Morten Colding-Jørgensen

    3. Chapter 7

      Biological Rhythms in Mental Disorders (pages 197–231)

      Hans A. Braun, Svetlana Postnova, Bastian Wollweber, Horst Schneider, Marcus Belke, Karlheinz Voigt, Harald Murck, Ulrich Hemmeter and Martin T. Huber

  3. Part III: Technologies for Simulating Drug Action and Effect

    1. Chapter 12

      Modeling Kidney Pressure and Flow Regulation (pages 313–348)

      O. V. Sosnovtseva, Prof. Dr. E. Mosekilde and N.-H. Holstein-Rathlou

  4. Part IV: Applications of Biosimulation

    1. Chapter 15

      Silicon Cell Models: Construction, Analysis, and Reduction (pages 401–423)

      Frank J. Bruggeman, Hanna M. Härdin, Jan H. van Schuppen and Prof. Dr. Hans V. Westerhoff

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