Nuclear Receptors as Drug Targets

Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA

Nuclear Receptors as Drug Targets

Editor(s): Eckhard Ottow, Hilmar Weinmann

Published Online: 19 DEC 2008

Print ISBN: 9783527318728

Online ISBN: 9783527623297

DOI: 10.1002/9783527623297

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

Product Information

About The Product

Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XXIV)

    2. Chapter 1

      Nuclear Receptors as Drug Targets: A Historical Perspective of Modern Drug Discovery (pages 1–23)

      Prof. Dr. Eckhard Ottow and Dr. Hilmar Weinmann

    3. Chapter 2

      Targeting the Nuclear Receptor–Cofactor Interaction (pages 25–45)

      Belen Vaz, Sabine Möcklinghoff and Luc Brunsveld

    4. Chapter 3

      Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen-Binding Receptors (pages 47–64)

      Ross V. Weatherman

    5. Chapter 4

      Subtype-Selective Estrogens (pages 65–126)

      Gerrit H. Veeneman

    6. Chapter 5

      Estrogen Receptors as Therapeutic Targets in Breast Cancer (pages 127–199)

      Eric A. Ariazi and V. Craig Jordan

    7. Chapter 6

      Progesterone Receptor: Overview of Modern Steroidal Progestins and Developments in the Field of Nonsteroidal Selective Progesterone Receptor Modulators (pages 201–222)

      Klaus Schöllkopf and Norbert Schmees

    8. Chapter 7

      Progesterone Receptor Antagonists (pages 223–248)

      Irving M. Spitz

    9. Chapter 8

      Nonsteroidal Tissue-Selective Androgen Receptor Modulators (pages 249–304)

      Michael L. Mohler, Casey E. Bohl, Ramesh Narayanan, Yali He, Dong Jin Hwang, James T. Dalton and Duane D. Miller

    10. Chapter 9

      Novel Glucocorticoid Receptor Ligands (pages 305–323)

      Heike Schäcke, Khusru Asadullah, Markus Berger and Hartmut Rehwinkel

    11. Chapter 10

      1,25-Dihydroxyvitamin D3 and its Dissociated Analogs as Modulators of Vitamin D Receptor Action (pages 325–365)

      Ekkehard May, Andreas Steinmeyer, Khusru Asadullah and Ulrich Zügel

    12. Chapter 11

      Peroxisome Proliferator-Activated Receptor γ Modulation for the Treatment of Type 2 Diabetes (pages 367–387)

      Alan M. Warshawsky and Anne Reifel Miller

    13. Chapter 12

      Retinoids in Clinical Use (pages 389–407)

      Vincent C. O. Njar

    14. Chapter 13

      Nuclear Receptors as Targets in Cardiovascular Diseases (pages 409–429)

      Peter Kolkhof, Lars Bärfacker, Alexander Hillisch, Helmut Haning and Stefan Schäfer

    15. Chapter 14

      NR4A Subfamily of Receptors and their Modulators (pages 431–451)

      Henri Mattes

    16. Chapter 15

      Induction of Drug Metabolism: Role for Nuclear Receptors (pages 453–468)

      Christoph Handschin

    17. Chapter 16

      Designing Chemical Libraries Directed to Nuclear Receptors (pages 469–488)

      Elisabet Gregori-Puigjané and Jordi Mestres

    18. You have free access to this content
      Index (pages 489–498)

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