Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability, Volume 40, Second Edition

Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability, Volume 40, Second Edition

Editor(s): Han van de Waterbeemd, Bernard Testa

Published Online: 10 NOV 2009

Print ISBN: 9783527320516

Online ISBN: 9783527623860

DOI: 10.1002/9783527623860

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten.
In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data.
Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process.
No other publication offers the same level of treatment on this crucial topic in modern drug development.

Table of contents

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  1. Part One: Physicochemical Aspects of Drug Dissolution and Solubility

  2. Part Two: Physicochemical and Biological Studies of Membrane Permeability and Oral Absorption

  3. Part Three: Role of Transporters and Metabolism in Oral Absorption

    1. Chapter 11

      Hepatic Transport (pages 277–332)

      Kazuya Maeda, Hiroshi Suzuki and Yuichi Sugiyama

  4. Part Four: Computational Approaches to Drug Absorption and Bioavailability

    1. Chapter 15

      Computational Absorption Prediction (pages 409–432)

      Christel A. S. Bergström, Markus Haeberlein and Ulf Norinder

  5. Part Five: Drug Development Issues

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