Next Generation Genome Sequencing: Towards Personalized Medicine

Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA

Next Generation Genome Sequencing: Towards Personalized Medicine

Editor(s): Michal Janitz

Published Online: 30 OCT 2008

Print ISBN: 9783527320905

Online ISBN: 9783527625130

DOI: 10.1002/9783527625130

About this Book

Product Information

About The Product

Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XX)

  2. Part One: Sanger DNA Sequencing

    1. Chapter 1

      Sanger DNA Sequencing (pages 1–11)

      Artem E. Men, Peter Wilson, Kirby Siemering and Susan Forrest

  3. Part Two: Next-Generation Sequencing: Toward Personalized Medicine

    1. Chapter 2

      Illumina Genome Analyzer II System (pages 13–28)

      Abizar Lakdawalla and Harper Vansteenhouse

    2. Chapter 3

      Applied Biosystems SOLiD™ System: Ligation-Based Sequencing (pages 29–42)

      Vicki Pandey, Robert C. Nutter and Ellen Prediger

    3. Chapter 4

      The Next-Generation Genome Sequencing: 454/Roche GS FLX (pages 43–56)

      Lei Du and Michael Egholm

    4. Chapter 5

      Polony Sequencing: History, Technology, and Applications (pages 57–76)

      Jeremy S. Edwards

  4. Part Three: The Bottleneck: Sequence Data Analysis

    1. Chapter 6

      Next-Generation Sequence Data Analysis (pages 77–88)

      Leonard N. Bloksberg

    2. Chapter 7

      DNASTAR's Next-Generation Software (pages 89–94)

      Tim Durfee and Thomas E. Schwei

  5. Part Four: Emerging Sequencing Technologies

    1. Chapter 8

      Real-Time DNA Sequencing (pages 95–101)

      Susan H. Hardin

    2. Chapter 9

      Direct Sequencing by TEM of Z-Substituted DNA Molecules (pages 103–116)

      William K. Thomas and William Glover

    3. Chapter 10

      A Single DNA Molecule Barcoding Method with Applications in DNA Mapping and Molecular Haplotyping (pages 117–132)

      Ming Xiao and Pui-Yan Kwok

    4. Chapter 11

      Optical Sequencing: Acquisition from Mapped Single-Molecule Templates (pages 133–151)

      Shiguo Zhou, Louise Pape and David C. Schwartz

    5. Chapter 12

      Microchip-Based Sanger Sequencing of DNA (pages 153–163)

      Ryan E. Forster, Christopher P. Fredlake and Annelise E. Barron

  6. Part Five: Next-Generation Sequencing: Truly Integrated Genome Analysis

    1. Chapter 13

      Multiplex Sequencing of Paired End Ditags for Transcriptome and Genome Analysis (pages 165–182)

      Chia-Lin Wei and Yijun Ruan

    2. Chapter 14

      Paleogenomics Using the 454 Sequencing Platform (pages 183–199)

      M. Thomas P. Gilbert

    3. Chapter 15

      ChIP-Seq: Mapping of Protein–DNA Interactions (pages 201–215)

      Anthony Peter Fejes and Steven J. M. Jones

    4. Chapter 16

      MicroRNA Discovery and Expression Profiling using Next-Generation Sequencing (pages 217–228)

      Eugene Berezikov and Edwin Cuppen

    5. Chapter 17

      DeepSAGE: Tag-Based Transcriptome Analysis Beyond Microarrays (pages 229–244)

      Kåre L. Nielsen, Annabeth H. Petersen and Jeppe Emmersen

    6. Chapter 18

      The New Genomics and Personal Genome Information: Ethical Issues (pages 245–254)

      Jeantine E. Lunshof

    1. You have free access to this content
      Index (pages 255–260)

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