Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates

Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA

Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates

Editor(s): Paul M. Selzer

Published Online: 28 JUL 2009

Print ISBN: 9783527323272

Online ISBN: 9783527626816

DOI: 10.1002/9783527626816

About this Book

Product Information

About The Product

Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XX)

  2. Part One: Drug Discovery Approaches

    1. Chapter 1

      Target Identification and Mechanism-Based Screening for Anthelmintics: Application of Veterinary Antiparasitic Research Programs to Search for New Antiparasitic Drugs for Human Indications (pages 1–15)

      Timothy G. Geary, Debra J. Woods, Tracey Williams and Solomon Nwaka

    2. Chapter 2

      Anthelmintic Resistance as a Guide to the Discovery of New Drugs? (pages 17–32)

      Georg v. Samson-Himmelstjerna, Roger K. Prichard and Adrian J. Wolstenholme

    3. Chapter 3

      Drug Discovery for Neglected Diseases: View of A Public–Private Partnership (pages 33–43)

      Rob Don and Eric Chatelain

    4. Chapter 4

      Bioinformatics and Chemoinformatics: Key Technologies in the Drug Discovery Process (pages 45–57)

      Andreas Krasky, Andreas Rohwer, Richard J. Marhöfer and Prof. Dr. Paul M. Selzer

    5. Chapter 5

      Target Identification and Validation in Antiparasitic Drug Discovery (pages 59–73)

      Christian Wolf and Nikolas Gunkel

    6. Chapter 6

      Selective Drug Targets in Parasites (pages 75–98)

      Peter Köhler and Richard J. Marhöfer

    7. Chapter 7

      Lessons Learned from Target-Based Lead Discovery (pages 99–115)

      Michael Gassel, Jörg Cramer, Christopher Kern, Sandra Noack and Wolfgang Streber

    8. Chapter 8

      Approaches towards Antiparasitic Drug Candidates for Veterinary Use (pages 117–133)

      Christophe Chassaing and Harald Sekljic

    9. Chapter 9

      Learning to Relate Structural Space to Property Space (pages 135–158)

      Michael Berger, Jörg Cramer, Michael Hinz, Christina Mertens, Christian Miculka, Trevor Newton, Jörg Schröder and Harald Sekljic

    10. Chapter 10

      Recruiting the Host Defense Mechanisms: Roles for Vaccines and Chemotherapeutics (pages 159–173)

      Theo P. M. Schetters

  3. Part Two: Protozoan Parasites

    1. Chapter 11

      Proteases of Parasitic Protozoa – Current Status and Validation (pages 175–209)

      Mohammed Sajid, Michael J. Blackman, Patricia Doyle, Chen He, Kirkwood M. Land, Cheryl Lobo, Zachary Mackey, Momar Ndao, Sharon L. Reed, Brian Shiels, Ryan Swenerton and William Weir

    2. Chapter 12

      In Search of Trypanocidal Drugs (pages 211–226)

      Leopold Flohé

    3. Chapter 13

      Trypanosomatid Protein Kinases as Potential Drug Targets (pages 227–247)

      Martin Wiese, Andrew Morris and Karen M. Grant

    4. Chapter 14

      Targeting the Malaria Kinome: Discovering Kinase Inhibitors as Novel Antimalarial Agents (pages 249–276)

      Dayadevi Jirage, Susan M. Keenan and Norman C. Waters

    5. Chapter 15

      Malaria and Antimalarials – A Focused View (pages 277–298)

      Frank Seeber

  4. Part Three: Multicellular Parasites

    1. Chapter 16

      Chemotherapeutic Development Strategies for Schistosomiasis (pages 299–321)

      Conor R. Caffrey, David L. Williams, Matthew H. Todd, David L. Nelson, Jennifer Keiser and Jürg Utzinger

    2. Chapter 17

      Searching New Antiparasitics in Virtual Space (pages 323–338)

      Frank Oellien, Kristin Engels, Jörg Cramer, Richard J. Marhöfer, Christopher Kern and Prof. Dr. Paul M. Selzer

    3. Chapter 18

      Cyclooctadepsipeptides – An Anthelmintically Active Class of Compounds Exhibiting a Novel Mode of Action (pages 339–356)

      Achim Harder, Kathryn Bull, Marcus Guest, Lindy Holden-Dye and Robert Walker

    4. Chapter 19

      Chemical Optimization of Anthelmintic Compounds – A Case Study (pages 357–371)

      Thorsten Meyer, Jörg Schröder, Manfred Uphoff, Sandra Noack, Anja R. Heckeroth, Michael Gassel, Petra Rohrwild and Thomas Ilg

  5. Part Four: Bacteria

    1. Chapter 20

      Pathogenomics: Identification of Novel Drug Targets and Vaccine Candidates in Bacteria (pages 373–413)

      Knut Ohlsen, Martin Eckart, Ulrich Dobrindt, Heike Bruhn and Jörg Hacker

    2. Chapter 21

      Tuberculosis Drug Discovery: Issues, Gaps and the Way Forward (pages 415–440)

      Véronique Dartois, Franz Joel Leong and Thomas Dick

    3. Chapter 22

      Decreasing the Number of Gaps in the Draft Assembly of the Mannheimia Haemolytica M7/2 Genome Sequence (pages 441–451)

      Hon Q. Tran, Mathias Beig, Volker Spehr, Andreas Rohwer, Gottfried Unden and Prof. Dr. Paul M. Selzer

    4. Chapter 23

      Total Synthesis and Configurational Assignment of Pasteurestin A and B, a Natural Product with Antimicrobial Activity on Pasteurellaceae (pages 453–471)

      Marion Kögl, Lothar Brecker, Ralf Warrass and Johann Mulzer

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      Index (pages 473–489)

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