Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates

Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates

Editor(s): Paul M. Selzer

Published Online: 28 JUL 2009

Print ISBN: 9783527323272

Online ISBN: 9783527626816

DOI: 10.1002/9783527626816

About this Book

Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Table of contents

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  1. Part One: Drug Discovery Approaches

    1. Chapter 2

      Anthelmintic Resistance as a Guide to the Discovery of New Drugs? (pages 17–32)

      Georg v. Samson-Himmelstjerna, Roger K. Prichard and Adrian J. Wolstenholme

    2. Chapter 7

      Lessons Learned from Target-Based Lead Discovery (pages 99–115)

      Michael Gassel, Jörg Cramer, Christopher Kern, Sandra Noack and Wolfgang Streber

    3. Chapter 9

      Learning to Relate Structural Space to Property Space (pages 135–158)

      Michael Berger, Jörg Cramer, Michael Hinz, Christina Mertens, Christian Miculka, Trevor Newton, Jörg Schröder and Harald Sekljic

  2. Part Two: Protozoan Parasites

    1. Chapter 11

      Proteases of Parasitic Protozoa – Current Status and Validation (pages 175–209)

      Mohammed Sajid, Michael J. Blackman, Patricia Doyle, Chen He, Kirkwood M. Land, Cheryl Lobo, Zachary Mackey, Momar Ndao, Sharon L. Reed, Brian Shiels, Ryan Swenerton and William Weir

  3. Part Three: Multicellular Parasites

    1. Chapter 16

      Chemotherapeutic Development Strategies for Schistosomiasis (pages 299–321)

      Conor R. Caffrey, David L. Williams, Matthew H. Todd, David L. Nelson, Jennifer Keiser and Jürg Utzinger

    2. Chapter 17

      Searching New Antiparasitics in Virtual Space (pages 323–338)

      Frank Oellien, Kristin Engels, Jörg Cramer, Richard J. Marhöfer, Christopher Kern and Prof. Dr. Paul M. Selzer

    3. Chapter 19

      Chemical Optimization of Anthelmintic Compounds – A Case Study (pages 357–371)

      Thorsten Meyer, Jörg Schröder, Manfred Uphoff, Sandra Noack, Anja R. Heckeroth, Michael Gassel, Petra Rohrwild and Thomas Ilg

  4. Part Four: Bacteria

    1. Chapter 22

      Decreasing the Number of Gaps in the Draft Assembly of the Mannheimia Haemolytica M7/2 Genome Sequence (pages 441–451)

      Hon Q. Tran, Mathias Beig, Volker Spehr, Andreas Rohwer, Gottfried Unden and Prof. Dr. Paul M. Selzer

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