Epigenetic Targets in Drug Discovery, Volume 42
Copyright © 2009 Wiley-VCH Verlag GmbH & Co. KGaA
Editor(s): Wolfgang Sippl, Manfred Jung
Published Online: 25 FEB 2010
Print ISBN: 9783527323555
Online ISBN: 9783527627073
DOI: 10.1002/9783527627073
Book Series: Methods and Principles in Medicinal Chemistry
Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
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Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease.
The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.