Epigenetic Targets in Drug Discovery, Volume 42

Epigenetic Targets in Drug Discovery, Volume 42

Editor(s): Wolfgang Sippl, Manfred Jung

Published Online: 25 FEB 2010

Print ISBN: 9783527323555

Online ISBN: 9783527627073

DOI: 10.1002/9783527627073

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease.
The first part of the book surveys current methodologies for finding and validating drug candidates that act via epigenetic mechanisms. The second part systematically surveys known and suspected drug targets within the epigenetic machinery, including the discovery and development of vorinostat, the first marketed epigenetic drug.

Table of contents

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  1. Part One: General Aspects and Methodologies

    1. Chapter 2

      Structural Biology of Epigenetic Targets (pages 23–56)

      Christophe Romier, Jean-Marie Wurtz, Jean-Paul Renaud and Jean Cavarelli

  2. Part Two: Epigenetic Target Classes and Inhibitor Development

    1. Chapter 13

      Histone Demethylases (pages 269–290)

      Rasmus P. Clausen, Marianne T. Pedersen and Kristian Helin

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