Transporters as Drug Carriers: Structure, Function, Substrates, Volume 44

Transporters as Drug Carriers: Structure, Function, Substrates, Volume 44

Editor(s): Gerhard Ecker, Peter Chiba

Published Online: 9 MAR 2010

Print ISBN: 9783527316618

Online ISBN: 9783527627424

DOI: 10.1002/9783527627424

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.
As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general.
For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

Table of contents

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  1. Part One: Human Transporter Families – Structure, Function, Physiology

    1. Chapter 2

      Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters (pages 49–80)

      Marçal Pastor-Anglada, Míriam Molina-Arcas, Pedro Cano-Soldado and Francisco Javier Casado

  2. Part Two: Drug Transport in Microorganisms and Fungi

  3. Part Three: Structure Activity Relationship Studies on ABC Transporter

  4. Part Four: Transporters and ADME

  5. Part Five: A Systems View of Drug Transport

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