Epigenetics and Human Health: Linking Hereditary, Environmental and Nutritional Aspects

Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA

Epigenetics and Human Health: Linking Hereditary, Environmental and Nutritional Aspects

Editor(s): Alexander G. Haslberger

Published Online: 8 JAN 2010

Print ISBN: 9783527324279

Online ISBN: 9783527628384

DOI: 10.1002/9783527628384

About this Book

Product Information

About The Product

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment.
Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Table of contents

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      Front Matter (pages i–xxi)

  2. Part I: General Introduction

    1. Chapter 1

      The Research Program in Epigenetics: The Birth of a New Paradigm (pages 1–6)

      Paolo Vineis

    2. Chapter 2

      Interactions Between Nutrition and Health (pages 7–9)

      Ibrahim Elmadfa

    3. Chapter 3

      Epigenetics: Comments from an Ecologist (pages 11–12)

      Fritz Schiemer

    4. Chapter 4

      Interaction of Hereditary and Epigenetic Mechanisms in the Regulation of Gene Expression (pages 13–34)

      Thaler Roman, Eva Aumüller, Carolin Berner and Dr. Alexander G. Haslberger

  3. Part II: Hereditary Aspects

    1. Chapter 5

      Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Cancer Risk: A Review of the Published Meta-Analyses (pages 35–50)

      Stefania Boccia

    2. Chapter 6

      The Role of Biobanks for the Understanding of Gene–Environment Interactions (pages 51–62)

      Christian Viertler, Michaela Theresia Mayrhofer and Kurt Zatloukal

    3. Chapter 7

      Case Studies on Epigenetic Inheritance (pages 63–86)

      Gunnar Kaati

  4. Part III: Environmental and Toxicological Aspects

    1. Chapter 8

      Genotoxic, Non-Genotoxic and Epigenetic Mechanisms in Chemical Hepatocarcinogenesis: Implications for Safety Evaluation (pages 87–103)

      Wilfried Bursch

    2. Chapter 9

      Carcinogens in Foods: Occurrence, Modes of Action and Modulation of Human Risks by Genetic Factors and Dietary Constituents (pages 105–124)

      M. Mišík, A. Nersesyan, W. Parzefall and S. Knasmüller

  5. Part IV: Nutritional Aspects

    1. Chapter 10

      From Molecular Nutrition to Nutritional Systems Biology (pages 125–140)

      Guy Vergères

    2. Chapter 11

      Effects of Dietary Natural Compounds on DNA Methylation Related to Cancer Chemoprevention and Anticancer Epigenetic Therapy (pages 141–155)

      Barbara Maria Stefanska and Krystyna Fabianowska-Majewska

    3. Chapter 12

      Health Determinants Throughout the Life Cycle (pages 157–163)

      Petra Rust

  6. Part V: Case Studies

    1. Chapter 13

      Viral Infections and Epigenetic Control Mechanisms (pages 165–172)

      Klaus R. Huber

    2. Chapter 14

      Epigenetics Aspects in Gyneacology and Reproductive Medicine (pages 173–178)

      Alexander Just and Johannes Huber

    3. Chapter 15

      Epigenetics and Tumorigenesis (pages 179–194)

      Heidrun Karlic and Franz Varga

    4. Chapter 16

      Epigenetic Approaches in Oncology (pages 195–208)

      Sabine Zöchbauer-Müller and Robert M. Mader

    5. Chapter 17

      Epigenetic Dysregulation in Aging and Cancer (pages 209–224)

      Despina Komninou and John P. Richie

    6. Chapter 18

      The Impact of Genetic and Environmental Factors in Neurodegeneration: Emerging Role of Epigenetics (pages 225–243)

      Lucia Migliore and Fabio Coppedè

    7. Chapter 19

      Epigenetic Biomarkers in Neurodegenerative Disorders (pages 245–251)

      Borut Peterlin

    8. Chapter 20

      Epigenetic Mechanisms in Asthma (pages 253–263)

      Rachel L. Miller and Julie Herbstman

  7. Part VI: Ways to Translate the Concept

    1. Chapter 21

      Public Health Genomics – Integrating Genomics and Epigenetics into National and European Health Strategies and Policies (pages 265–279)

      Tobias Schulte in den Bäumen and Angela Brand

    2. Chapter 22

      Taking a First Step: Epigenetic Health and Responsibility (pages 281–285)

      Astrid H. Gesche

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      Index (pages 287–298)

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