Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

Editor(s): Peter J. Dunn, Andrew S. Wells, Michael T. Williams

Published Online: 19 MAR 2010

Print ISBN: 9783527324187

Online ISBN: 9783527629688

DOI: 10.1002/9783527629688

About this Book

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Table of contents

    1. You have free access to this content
    2. Chapter 2

      Green Chemistry Metrics (pages 21–48)

      Richard K. Henderson, David J. C. Constable and Concepción Jiménez-González

    3. Chapter 3

      Solvent Use and Waste Issues (pages 49–82)

      C. Stewart Slater, Mariano J. Savelski, William A. Carole and David J. C. Constable

    4. Chapter 5

      Synthesis of Sitagliptin, the Active Ingredient in Januvia® and Janumet® (pages 101–126)

      Jaume Balsells, Yi Hsiao, Karl B. Hansen, Feng Xu, Norihiro Ikemoto, Andrew Clausen and Joseph D. Armstrong

    5. Chapter 11

      Continuous Processing in the Pharmaceutical Industry (pages 221–242)

      Lee Proctor, Dr. Peter J. Dunn, Joel M. Hawkins, Dr. Andrew S. Wells and Dr. Michael T. Williams

    6. Chapter 12

      Preparative and Industrial Scale Chromatography: Green and Integrated Processes (pages 243–268)

      Eric Lang, Eric Valéry, Olivier Ludemann-Hombourger, Wieslaw Majewski and Jean Bléhaut

    7. You have free access to this content