The Chemical Biology of DNA Damage
Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA
Editor(s): Nicholas E. Geacintov, Suse Broyde
Published Online: 11 OCT 2010 12:14PM EST
Print ISBN: 9783527322954
Online ISBN: 9783527630110
About this Book
Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.
A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.