Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling

Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA

Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling

Editor(s): Felix Tretter, Peter J. Gebicke-Haerter, Eduardo R. Mendoza, Georg Winterer

Published Online: 14 JUL 2010

Print ISBN: 9783527325030

Online ISBN: 9783527630271

DOI: 10.1002/9783527630271

About this Book

Product Information

About The Product

This first book to provide a comprehensive overview of the recent progress made in this break-through approach includes expert contributions from a variety of disciplines. Particular focus is placed on high-throughput methods and the analysis of data thus obtained, as well as their use in silico experiments so as to gain an insight into the complex biological processes in neuronal systems.
A must-have for everyone working in psychiatric research.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XX)

  2. Part One: Introduction

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      Part Introduction (page 1)

    2. Chapter 1

      Philosophical Aspects of Neuropsychiatry (pages 3–25)

      Prof. Dr. Felix Tretter

    3. Chapter 2

      Neuropsychiatry – Subject, Concepts, Methods, and Computational Models (pages 27–80)

      Prof. Dr. Felix Tretter and Prof. Dr. Peter J. Gebicke-Haerter

    4. Chapter 3

      Introduction to Systems Biology (pages 81–95)

      Marvin Schulz and Edda Klipp

    5. Chapter 4

      Mind over Molecule: Systems Biology for Neuroscience and Psychiatry (pages 97–109)

      Denis Noble

  3. Part Two: Basics

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      Part Introduction (page 111)

    2. Chapter 5

      Neuropsychiatry, Psychopathology, and Nosology – Symptoms, Syndromes, and Endophenotypes (pages 113–127)

      Wolfram Kawohl and Paul Hoff

    3. Chapter 6

      System Properties of Populations of Neurons in Cerebral Cortex (pages 129–144)

      Walter J. Freeman

    4. Chapter 7

      Dopamine and the Electrophysiology of Prefrontal Cortical Networks (pages 145–157)

      Patricio O'Donnell

  4. Part Three: Research in Molecular Psychiatry

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      Part Introduction (page 159)

    2. Chapter 8

      Nicotinic Cholinergic Signaling in the Human Brain – Systems Perspective (pages 161–188)

      Arian Mobascher and Prof. Dr. Georg Winterer

    3. Chapter 9

      Progress in Psychopharmacotherapy though Molecular Imaging (pages 189–206)

      Ingo Vernaleken, Gerhard Gruender and Paul Cumming

    4. Chapter 10

      The Marriage of Phenomics and Genetical Genomics: A Systems Approach to Complex Trait Analysis (pages 207–227)

      Laura M. Saba, Paula L. Hoffman, Lawrence E. Hunter and Boris Tabakoff

  5. Part Four: Data Mining and Modeling

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      Part Introduction (page 229)

    2. Chapter 11

      From Communicational to Computational: Systems Modeling Approaches for Psychiatric Research (pages 231–242)

      Dr. Eduardo R. Mendoza

    3. Chapter 12

      Network Dynamics as an Interface between Modeling and Experiment in Systems Biology (pages 243–276)

      James Smith and Marc-Thorsten Hütt

    4. Chapter 13

      Some Useful Mathematical Tools to Transform Microarray Data into Interactive Molecular Networks (pages 277–300)

      Franziska Matthäus, V. Anne Smith and Prof. Dr. Peter J. Gebicke-Haerter

    5. Chapter 14

      Biochemical Networks in Psychiatric Disease (pages 301–320)

      Maria Lindskog, Geir Halnes, Rodrigo F. Oliveira, Jeanette Hellgren Kotaleski and Kim T. Blackwell

    6. Chapter 15

      Local Cortical Dynamics Related to Mental Illnesses (pages 321–339)

      Marco Loh, Edmund T. Rolls and Gustavo Deco

    7. Chapter 16

      Epilogue (pages 341–345)

      Prof. Dr. Peter J. Gebicke-Haerter

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      Index (pages 347–358)

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