Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions, Second Edition

Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions, Second Edition

Editor(s): Hans-Ulrich Blaser, Hans-Jürgen Federsel

Published Online: 8 JUN 2010

Print ISBN: 9783527324897

Online ISBN: 9783527630639

DOI: 10.1002/9783527630639

About this Book

This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.
The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the catalytic step fits into the overall synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, including finding/developing the catalyst and optimization of the process or choice of equipment. Both successful and unsuccessful approaches to solve these problems are described.

Table of contents

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  1. Part I: New Processes for Existing Active Compounds (APIs)

  2. Part II: Processes for Important Buildings Blocks

    1. Chapter 8

      Asymmetric Hydrogenation of a 2-Isopropylcinnamic Acid Derivative en Route to the Blood Pressure-Lowering Agent Aliskiren (pages 127–150)

      Jeroen A. F. Boogers, Dirk Sartor, Ulfried Felfer, Martina Kotthaus, Gerhard Steinbauer, Bert Dielemans, Laurent Lefort, André H. M. de Vries and Johannes G. de Vries

  3. Part III: Processes for New Chemical Entities (NCEs)

    1. Chapter 21

      Scale-Up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor (pages 377–396)

      Hans Iding, Beat Wirz, Jean-Michel Adam, Pascal Dott, Wolfgang Haap, Rosa Maria Rodríguez Sarmiento, Thomas Oberhauser, Reinhard Reents, Rolf Fischer and Stephan Lauper

    2. Chapter 26

      Large-Scale Application of Asymmetric Phase-Transfer Catalysis for Amino Acid Synthesis (pages 473–484)

      Daniel E. Patterson, Shiping Xie, Lynda A. Jones, Martin H. Osterhout, Christopher G. Henry and Thomas D. Roper

    3. Chapter 28

      Asymmetric Synthesis of HCV and HPV Drug Candidates on Scale: The Choice between Enantioselective and Diastereoselective Syntheses (pages 499–522)

      Jeremy D. Cobb, Bob E. Cooley, Roy C. Flanagan, Mary M. Jackson, Lynda A. Jones, Richard T. Matsuoka, Alan Millar, Daniel E. Patterson, Matthew J. Sharp, Jennifer F. Toczko, Shiping Xie and Xiaoming Zhou

    1. You have free access to this content