Metabolism of Drugs and Other Xenobiotics

Metabolism of Drugs and Other Xenobiotics

Editor(s): Pavel Anzenbacher, Ulrich M. Zanger

Published Online: 4 JUN 2012

Print ISBN: 9783527329038

Online ISBN: 9783527630905

DOI: 10.1002/9783527630905

About this Book

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides
systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews
the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three
main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from
five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse

including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular
Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Table of contents

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  1. Part One: Biochemistry and Molecular Genetics of Drug Metabolism

    1. Chapter 7

      Transporting Systems (pages 199–222)

      Anne T. Nies, Claudia Resch and Tadashi Namisaki

    2. Chapter 9

      Importance of Pharmacogenomics (pages 259–284)

      Prof. Dr. Ulrich M. Zanger, Kathrin Klein and Jessica Rieger

  2. Part Two: Metabolism of Drugs

    1. Chapter 12

      Cardiovascular Drugs (pages 331–363)

      Stephan Riedmaier and Prof. Dr. Ulrich M. Zanger

    2. Chapter 13

      Anticancer Drugs (pages 365–378)

      Matthias Schwab, Elke Schaeffeler and Hiltrud Brauch

    3. Chapter 14

      Antimicrobial Agents (pages 379–402)

      Chantal Csajka, Oscar Marchetti, Oriol Manuel, Laurent Decosterd and Amalio Telenti

  3. Part Three: Metabolism of Natural Compounds

  4. Part Four: Metabolism of Unnatural Xenobiotics

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