Aspartic Acid Proteases as Therapeutic Targets
Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA
Editor(s): Arun K. Ghosh
Published Online: 4 APR 2011 01:15PM EST
Print ISBN: 9783527318117
Online ISBN: 9783527630943
Book Series: Methods and Principles in Medicinal Chemistry
Series Editor(s): R. Mannhold, H. Kubinyi, G. Folkers
About this Book
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.