Aspartic Acid Proteases as Therapeutic Targets

Aspartic Acid Proteases as Therapeutic Targets

Editor(s): Arun K. Ghosh

Published Online: 4 APR 2011 01:15PM EST

Print ISBN: 9783527318117

Online ISBN: 9783527630943

DOI: 10.1002/9783527630943

Series Editor(s): R. Mannhold, H. Kubinyi, G. Folkers

About this Book

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases.
A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Table of contents

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  1. Part One: Overview of Aspartic Acid Proteases

  2. Part Two: HIV-1 Protease as Target for the Treatment of HIV/AIDS

  3. Part Three: Renin as Target for the Treatment of Hypertension

  4. Part Four: γ-Secretase as Target for the Treatment of Alzheimer's Disease

  5. Part Five: β-Secretase as Target for the Treatment of Alzheimer's Disease

  6. Part Six: Plasmepsins and Other Aspartic Proteases as Drug Targets

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