Chemokine Receptors as Drug Targets

Chemokine Receptors as Drug Targets

Editor(s): Martine J. Smit, Sergio A. Lira, Rob Leurs

Published Online: 4 APR 2011 01:40PM EST

Print ISBN: 9783527321186

Online ISBN: 9783527631995

DOI: 10.1002/9783527631995

Series Editor(s): R. Mannhold, H. Kubinyi, G. Folkers

About this Book

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.
Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Table of contents

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  1. Part One: Fundamentals of Chemokines and Chemokine Receptors

    1. Chapter 2

      Structural Insights for Homology Modeling of Chemokine Receptors (pages 33–50)

      Leonardo Pardo, Xavier Deupi, Arnau Cordomí, Cedric Govaerts and Mercedes Campillo

    2. Chapter 4

      The Atypical Chemokine Receptors (pages 67–83)

      Mark D. Singh, Robert J. B. Nibbs and Gerard J. Graham

  2. Part Two: Chemokine Receptors in Disease

    1. Chapter 6

      Chemokine Receptors in Inflammatory Diseases (pages 105–150)

      Aletta D. Kraneveld, Saskia Braber, Saskia Overbeek, Petra de Kruijf, Pim Koelink and Prof. Dr. Martine J. Smit

  3. Part Three: Targeting Chemokine Receptors

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