Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications, Second Edition

Copyright © 2012 Wiley-VCH Verlag GmbH & Co. KGaA

Pharmaceutical Biotechnology: Drug Discovery and Clinical Applications, Second Edition

Editor(s): Oliver Kayser, Heribert Warzecha

Published Online: 17 APR 2012 04:54AM EST

Print ISBN: 9783527329946

Online ISBN: 9783527632909

DOI: 10.1002/9783527632909

About this Book

This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations.
With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.

Table of contents

    1. You have free access to this content
      Front Matter (pages I–XXVII)

  2. Part One: Concepts and Methods for Recombinant Drug Production

    1. Chapter 1

      Pharmaceutical Biotechnology and Industrial Applications–Learning Lessons from Molecular Biology (pages 1–13)

      Prof. Dr. Oliver Kayser and Prof. Dr. Heribert Warzecha

    2. Chapter 2

      Prokaryotic Cells in Biotech Production (pages 15–41)

      Andriy Luzhetskyy, Gabriele Weitnauer and Andreas Bechthold

    3. Chapter 3

      Mammalian Cells in Biotech Production (pages 43–57)

      Maria J. De Jesus and Florian M. Wurm

    4. Chapter 4

      Biopharmaceuticals from Plants (pages 59–69)

      Prof. Dr. Heribert Warzecha

    5. Chapter 5

      Production of Biopharmaceuticals in Transgenic Animals (pages 71–111)

      Heiner Niemann, Alexander Kind and Angelika Schnieke

    6. Chapter 6

      Translation of New Technologies in Biomedicines: Shaping the Road from Basic Research to Drug Development and Clinical Application–and Back Again (pages 113–152)

      Michael Balls, Andrew Bennett and David Kendall

  3. Part Two: Bringing the Drug into Action–From Downstreaming to Approval

    1. Chapter 7

      Overview and Classification of Approved Recombinant Drugs (pages 153–178)

      Theo Dingermann and Ilse Zündorf

    2. Chapter 8

      Downstream Processing (pages 179–199)

      Uwe Gottschalk

    3. Chapter 9

      Characterization of Recombinant Proteins (pages 201–234)

      Christoph Giese, Henning von Horsten and Stefan Zietze

    4. Chapter 10

      Formulation Strategies for Recombinant Protein and Related Biotech Drugs (pages 235–256)

      Gerhard Winter and Julia Myschik

    5. Chapter 11

      Drug Approval in the European Union and United States (pages 257–267)

      Gary Walsh

    6. Chapter 12

      Patents in the Pharmaceutical Biotechnology Industry: Legal and Ethical Issues (pages 269–284)

      David B. Resnik

    7. Chapter 13

      Biosimilar Drugs (pages 285–335)

      Walter Hinderer

    8. Chapter 14

      Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins (pages 337–367)

      Yi Zhang and Bernd Meibohm

  4. Part Three: Vaccines

    1. Chapter 15

      Scientific, Technical, and Economic Aspects of Vaccine Research and Development (pages 369–389)

      Jens-Peter Gregersen

    2. Chapter 16

      New Nanobiotechnological Strategies for the Development of Vectors for Cancer Vaccines (pages 391–421)

      Sean M. Geary, Caitlin D. Lemke, Yogita Krishnamachari and Aliasger K. Salem

    3. Chapter 17

      Recombinant Vaccines: Development, Production, and Application (pages 423–449)

      Luke R. Le Grand, Michaela White, Evan B. Siegel and Ross T. Barnard

  5. Part Four: Recent Applications in Pharmaceutical Biotechnology

    1. Chapter 18

      In Silico and Ultrahigh-Throughput Screenings (uHTS) in Drug Discovery: An Overview (pages 451–490)

      Debmalya Barh, Shoaib Ahmad and Atanu Bhattacharjee

    2. Chapter 19

      Metabolic Engineering of Medicinal Plants and Microorganisms for the Production of Natural Products (pages 491–526)

      Oktavia Hendrawati, Herman J. Woerdenbag, Jacques Hille and Prof. Dr. Oliver Kayser

    3. Chapter 20

      Metabolomics as a Bioanalytical Tool for Characterization of Medicinal Plants and Their Phytomedical Preparations (pages 527–552)

      Nizar Happyana, Remco Muntendam and Prof. Dr. Oliver Kayser

    4. Chapter 21

      Integration of Biotechnologies for the Development of Personalized Medicine (pages 553–580)

      Kewal K. Jain

    5. Chapter 22

      Xenotransplantation in Pharmaceutical Biotechnology (pages 581–597)

      Gregory J. Brunn and Jeffrey L. Platt

    6. Chapter 23

      Nutraceuticals–Functional Foods for Improving Health and Preventing Disease (pages 599–628)

      Jian Zhao

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      Index (pages 629–647)

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