Prodrugs and Targeted Delivery: Towards Better ADME Properties

Prodrugs and Targeted Delivery: Towards Better ADME Properties

Editor(s): Jarkko Rautio

Published Online: 4 APR 2011 01:43PM EST

Print ISBN: 9783527326037

Online ISBN: 9783527633166

DOI: 10.1002/9783527633166

Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

About this Book

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs.
Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

Table of contents

    1. You have free access to this content
  1. Part One: Prodrug Design and Intellectual Property

  2. Part Two: Prodrugs Addressing ADMET Issues

    1. Chapter 8

      Ocular Delivery Using Prodrugs (pages 181–205)

      Deep Kwatra, Ravi Vaishya, Ripal Gaudana, Jwala Jwala and Ashim K. Mitra

    2. Chapter 12

      Directed Enzyme Prodrug Therapies (pages 271–344)

      Dan Niculescu-Duvaz, Gabriel Negoita-Giras, Ion Niculescu-Duvaz, Douglas Hedley and Caroline J. Springer

  3. Part Three: Codrugs and Soft Drugs

  4. Part Four: Preclinical and Clinical Consideration for Prodrugs

    1. You have free access to this content

SEARCH