Protein Kinases as Drug Targets

Protein Kinases as Drug Targets

Editor(s): Bert Klebl, Gerhard Müller, Michael Hamacher

Published Online: 12 MAY 2011 09:20AM EST

Print ISBN: 9783527317905

Online ISBN: 9783527633470

DOI: 10.1002/9783527633470

Series Editor(s): R. Mannhold, H. Kubinyi, G. Folkers

About this Book

This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs.
Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.

Table of contents

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  1. Part One: Hit Finding and Profiling for Protein Kinases: Assay Development and Screening, Libraries

  2. Part Two: Medicinal Chemistry

  3. Part Three: Application of Kinase Inhibitors to Therapeutic Indication Areas

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