Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Editor(s): Katja Becker

Published Online: 21 FEB 2011 10:59AM EST

Print ISBN: 9783527327317

Online ISBN: 9783527633883

DOI: 10.1002/9783527633883

Series Editor(s): Paul M. Selzer

About this Book

This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.

Table of contents

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  1. Part One: Screening, Bioinformatics, Chemoinformatics, and Drug Design

    1. Chapter 1

      Drug Discovery Approaches toward Anti-Parasitic Agents (pages 1–20)

      Andreas Rohwer, Richard J. Marhöfer, Conor R. Caffrey and Prof. Dr. Paul M. Selzer

  2. Part Two: Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches

    1. Chapter 6

      Polyamines in Apicomplexan Parasites (pages 97–114)

      Ingrid B. Müller, Robin Das Gupta, Kai Lüersen, Carsten Wrenger and Rolf D. Walter

    2. Chapter 8

      Lipids as Drug Targets for Malaria Therapy (pages 137–162)

      Henri J. Vial, Diana Penarete, Sharon Wein, Sergio Caldarelli, Laurent Fraisse and Suzanne Peyrottes

    3. Chapter 14

      Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen Cryptosporidium (pages 271–285)

      Suresh Kumar Gorla, Corey Johnson, Jihan Khan, Xin Sun, Lisa Sharling, Boris Striepen and Lizbeth Hedstrom

  3. Part Three: Drug Targets in Apicomplexan Parasites

  4. Part Four: Compounds

    1. Chapter 26

      Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites? (pages 481–492)

      Christian Miculka, Hon Q. Tran, Thorsten Meyer, Anja R. Heckeroth, Stefan Baumeister, Frank Seeber and Prof. Dr. Paul M. Selzer

    2. Chapter 27

      Recent Drug Discovery against Cryptosporidium (pages 493–512)

      Jean-François Rossignol, J. Edward Semple, Andrew V. Stachulski and Gilles Gargala

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