Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Copyright © 2011 Wiley-VCH Verlag GmbH & Co. KGaA

Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Editor(s): Katja Becker

Published Online: 21 FEB 2011 10:59AM EST

Print ISBN: 9783527327317

Online ISBN: 9783527633883

DOI: 10.1002/9783527633883

Series Editor(s): Paul M. Selzer

About this Book

Product Information

About The Product

This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.

Table of contents

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      Front Matter (pages I–XXI)

  2. Part One: Screening, Bioinformatics, Chemoinformatics, and Drug Design

    1. Chapter 1

      Drug Discovery Approaches toward Anti-Parasitic Agents (pages 1–20)

      Andreas Rohwer, Richard J. Marhöfer, Conor R. Caffrey and Prof. Dr. Paul M. Selzer

    2. Chapter 2

      New Bioinformatic Strategies against Apicomplexan Parasites (pages 21–33)

      Thomas Dandekar and Ke Xiao

    3. Chapter 3

      Sorting Potential Therapeutic Targets in Apicomplexa (pages 35–51)

      Jan A. Hiss and Gisbert Schneider

    4. Chapter 4

      Alternatives to Drug Development in the Apicomplexa (pages 53–73)

      Theo P. M. Schetters

  3. Part Two: Metabolic Pathways and Processes Addressed by Current Drug Discovery Approaches

    1. Chapter 5

      Energy Metabolism as an Antimalarial Drug Target (pages 75–95)

      Esther Jortzik and Prof. Dr. Katja Becker

    2. Chapter 6

      Polyamines in Apicomplexan Parasites (pages 97–114)

      Ingrid B. Müller, Robin Das Gupta, Kai Lüersen, Carsten Wrenger and Rolf D. Walter

    3. Chapter 7

      The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents: Methylene Blue as an Ethical Drug (pages 115–136)

      Peter Meissner, Heike Adler, Denis Kasozi, Karin Fritz-Wolf and R. Heiner Schirmer

    4. Chapter 8

      Lipids as Drug Targets for Malaria Therapy (pages 137–162)

      Henri J. Vial, Diana Penarete, Sharon Wein, Sergio Caldarelli, Laurent Fraisse and Suzanne Peyrottes

    5. Chapter 9

      Targeting Apicoplast Pathways in Plasmodium (pages 163–186)

      Snober S. Mir, Subir Biswas and Saman Habib

    6. Chapter 10

      Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites (pages 187–203)

      Janet Storm, Eva-Maria Patzewitz and Sylke Müller

    7. Chapter 11

      Antimalarial Drugs and Molecules Inhibiting Hemozoin Formation (pages 205–234)

      Uday Bandyopadhyay and Sumanta Dey

    8. Chapter 12

      Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets (pages 235–249)

      Carsten Wrenger and Ingrid B. Müller

    9. Chapter 13

      Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Targeting Protein–Protein Interaction (pages 251–270)

      Ivo Tews and Irmgard Sinning

    10. Chapter 14

      Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen Cryptosporidium (pages 271–285)

      Suresh Kumar Gorla, Corey Johnson, Jihan Khan, Xin Sun, Lisa Sharling, Boris Striepen and Lizbeth Hedstrom

  4. Part Three: Drug Targets in Apicomplexan Parasites

    1. Chapter 15

      Novel Apicomplexan Phosphatases and Immunophilins as Domain-Specific Drug Targets (pages 287–306)

      Sailen Barik

    2. Chapter 16

      Dehydrogenases and Enzymes of the Mitochondrial Electron Transport Chain as Anti-Apicomplexan Drug Targets (pages 307–318)

      Kathleen Zocher, Stefan Rahlfs and Prof. Dr. Katja Becker

    3. Chapter 17

      Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites (pages 319–333)

      Dominik Kugelstadt, Bianca Derrer and Barbara Kappes

    4. Chapter 18

      Protein Acylation: New Potential Targets for Intervention against the Apicomplexa (pages 335–357)

      Joana M. Santos, Christian Hedberg and Dominique Soldati-Favre

    5. Chapter 19

      Drugs and Drug Targets in Neospora caninum and Related Apicomplexans (pages 359–371)

      Joachim Müller, Norbert Müller and Andrew Hemphill

  5. Part Four: Compounds

    1. Chapter 20

      Subversive Substrates of Glutathione Reductases from Plasmodium falciparum-Infected Red Blood Cells as Antimalarial Agents (pages 373–396)

      Elisabeth Davioud-Charvet and Don Antoine Lanfranchi

    2. Chapter 21

      Ferroquine: A Concealed Weapon (pages 397–411)

      Christophe Biot, Bruno Pradines and Daniel Dive

    3. Chapter 22

      Current Aspects of Endoperoxides in Antiparasitic Chemotherapy (pages 413–430)

      Denis Matovu Kasozi, Stefan Rahlfs and Prof. Dr. Katja Becker

    4. Chapter 23

      Plasmodium Hsp90 as an Antimalarial Target (pages 431–451)

      G. Sridhar Prasad, Nicholas D. P. Cosford and Sailen Barik

    5. Chapter 24

      Drug Discovery against Babesia and Toxoplasma (pages 453–467)

      Mohamad Alaa Terkawi and Ikuo Igarashi

    6. Chapter 25

      Search for Drugs and Drug Targets against Babesia bovis, Babesia bigemina, Babesia caballi, and Babesia (Theileria) equi (pages 469–480)

      Sabine Bork-Mimm

    7. Chapter 26

      Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites? (pages 481–492)

      Christian Miculka, Hon Q. Tran, Thorsten Meyer, Anja R. Heckeroth, Stefan Baumeister, Frank Seeber and Prof. Dr. Paul M. Selzer

    8. Chapter 27

      Recent Drug Discovery against Cryptosporidium (pages 493–512)

      Jean-François Rossignol, J. Edward Semple, Andrew V. Stachulski and Gilles Gargala

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      Index (pages 513–528)

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