Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Editor(s): Achille G. Gravanis, Synthia H. Mellon

Published Online: 2 FEB 2011 09:28AM EST

Print ISBN: 9783527326273

Online ISBN: 9783527633968

DOI: 10.1002/9783527633968

About this Book

As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis.
The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.

Table of contents

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  1. Part I: Estrogens, Progestins, Allopregnanolone and Neuroprotection

  2. Part II: Glucocorticoids, Dehydroepiandrosterone, Neuroprotection and Neuropathy

    1. Chapter 6

      Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists (pages 103–120)

      Paul J. Lucassen, Carlos P. Fitzsimons, Erno Vreugdenhil, Pu Hu, Charlotte Oomen, Yanina Revsin, Marian Joëls and Edo Ronald de Kloet

    2. Chapter 7

      Neuroactive Steroids and Peripheral Neuropathy (pages 121–135)

      Roberto C. Melcangi, Silvia Giatti, Marzia Pesaresi, Donatella Caruso and Marc J. Tetel

    3. Chapter 9

      Neurosteroids and Pain (pages 155–170)

      Christine Patte-Mensah, Laurence Meyer, Véronique Schaeffer, Cherkaouia Kibaly and Ayikoe G. Mensah-Nyagan

  3. Part III: Polypeptide Hormones and Neuroprotection

    1. Chapter 11

      Leptin Neuroprotection in the Central Nervous System (pages 189–203)

      Feng Zhang, Suping Wang, Armando P. Signore, Zhongfang Weng and Jun Chen

    2. Chapter 13

      Neurotrophic Effects of PACAP in the Cerebellar Cortex (pages 227–236)

      Anthony Falluel-Morel, Hubert Vaudry, Hitoshi Komuro, Dariusz C. Gorecki, Ludovic Galas and David Vaudry

  4. Part IV: Hormones and Neurogenesis

    1. Chapter 16

      Thyroid Hormone Actions on Glioma Cells (pages 265–279)

      Min Zhou, Harold K. Kimelberg, Faith B. Davis and Paul J. Davis

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