Drug Delivery in Oncology: From Basic Research to Cancer Therapy

Drug Delivery in Oncology: From Basic Research to Cancer Therapy

Editor(s): Felix Kratz, Peter Senter, Henning Steinhagen

Published Online: 16 DEC 2011 07:12AM EST

Print ISBN: 9783527328239

Online ISBN: 9783527634057

DOI: 10.1002/9783527634057

About this Book

In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field.

The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field.

By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

Table of contents

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  1. Part I: Principles of Tumor Targeting

  2. Part II: Tumor Imaging

    1. Chapter 9

      Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT (pages 247–288)

      Andreas K. Buck, Florian Gärtner, Ambros Beer, Ken Herrmann, Sibylle Ziegler and Markus Schwaiger

  3. Part III: Macromolecular Drug Delivery Systems - Antibody-Based Systems

    1. Chapter 10

      Empowered Antibodies for Cancer Therapy (pages 289–323)

      Stephen C. Alley, Simone Jeger, Robert P. Lyon, Django Sussman and Peter D. Senter

  4. Part III: Macromolecular Drug Delivery Systems - Polymer-Based Systems

    1. Chapter 23

      Polysaccharide-Based Drug Conjugates for Tumor Targeting (pages 701–746)

      Gurusamy Saravanakumar, Jae Hyung Park, Kwangmeyung Kim and Ick Chan Kwon

  5. Part IV: Nano- and Microparticulate Drug Delivery Systems - Lipid-Based Systems

    1. Chapter 27

      Overview on Nanocarriers as Delivery Systems (pages 885–905)

      Haifa Shen, Elvin Blanco, Biana Godin, Rita E. Serda, Agathe K. Streiff and Mauro Ferrari

    2. Chapter 31

      Nanoscale Delivery Systems for Combination Chemotherapy (pages 1013–1050)

      Barry D. Liboiron, Paul G. Tardi, Troy O. Harasym and Lawrence D. Mayer

  6. Part IV: Nano- and Microparticulate Drug Delivery Systems - Polymer-Based Systems

    1. Chapter 36

      Carbon Nanotubes (pages 1163–1185)

      David A. Scheinberg, Carlos H. Villa, Freddy Escorcia and Michael R. McDevitt

  7. Part V: Ligand-Based Drug Delivery Systems

  8. Part VI: Special Topics

    1. Chapter 47

      Liver Tumor Targeting (pages 1519–1568)

      Katrin Hochdörffer, Giuseppina Di Stefano, Hiroshi Maeda and Dr. Felix Kratz

    2. Chapter 48

      Photodynamic Therapy: Photosensitizer Targeting and Delivery (pages 1569–1603)

      Pawel Mroz, Sulbha K. Sharma, Timur Zhiyentayev, Ying-Ying Huang and Michael R. Hamblin

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