Lipids and Cellular Membranes in Amyloid Diseases

Lipids and Cellular Membranes in Amyloid Diseases

Editor(s): Raz Jelinek

Published Online: 5 APR 2011 02:08PM EST

Print ISBN: 9783527328604

Online ISBN: 9783527634323

DOI: 10.1002/9783527634323

About this Book

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation.
Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders.

From the contents:

* Interactions of Alpha-Synuclein with Lipids
* Interaction of hIAPP and its Precursors with Membranes
* Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine
* The Role of Lipid Rafts in Alzheimer's Disease
* Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases
* Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease
* Membrane Changes in BSE and Scrapie
* Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions

and more

Table of contents

    1. You have free access to this content
    2. Chapter 1

      Interactions of α-Synuclein with Lipids and Artificial Membranes Monitored by ESIPT Probes (pages 1–31)

      Volodymyr V. Shvadchak, Lisandro J. Falomir-Lockhart, Dmytro A. Yushchenko and Thomas M. Jovin

    3. Chapter 2

      Structural and Functional Insights into α-Synuclein–Lipid Interactions (pages 33–55)

      Martin Stöckl, Bart D. van Rooijen, Mireille M. A. E. Claessens and Vinod Subramaniam

    4. Chapter 4

      Interaction of hIAPP and Its Precursors with Model and Biological Membranes (pages 93–120)

      Katrin Weise, Rajesh Mishra, Suman Jha, Daniel Sellin, Diana Radovan, Andrea Gohlke, Christoph Jeworrek, Janine Seeliger, Simone Möbitz and Roland Winter

    5. You have free access to this content