Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives

Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives

Editor(s): Roland Kontermann

Published Online: 6 FEB 2012 04:44AM EST

Print ISBN: 9783527328499

Online ISBN: 9783527644827

DOI: 10.1002/9783527644827

About this Book

For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.

Table of contents

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  1. Part One: General Information

  2. Part Two: Half-Life Extension through Chemical and Post-Translational Modifications

  3. Part Three: Half-Life Modulation Involving Recycling by the Neonatal Fc Receptor

    1. Chapter 10

      Monomeric Fc Fusion Technology: An Approach to Create Long-Lasting Clotting Factors (pages 189–206)

      Jennifer A. Dumont, Xiaomei Jin, Robert T. Peters, Alvin Luk, Glenn F. Pierce and Alan J. Bitonti

  4. Part Four: Half-Life Extension with Pharmaceutical Formulations

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