Matrix Proteases in Health and Disease

Matrix Proteases in Health and Disease

Editor(s): Niels Behrendt

Published Online: 24 AUG 2012 04:33AM EST

Print ISBN: 9783527329915

Online ISBN: 9783527649327

DOI: 10.1002/9783527649327

About this Book

Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition.

With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.

Table of contents

    1. You have free access to this content
    2. Chapter 1

      Matrix Proteases and the Degradome (pages 5–23)

      Clara Soria-Valles, Carlos López-Otín and Ana Gutiérrez-Fernández

    3. Chapter 12

      ADAMs in Cancer (pages 299–324)

      Dorte Stautz, Sarah Louise Dombernowsky and Marie Kveiborg

    4. You have free access to this content

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