Parasitic Helminths: Targets, Screens, Drugs and Vaccines

Parasitic Helminths: Targets, Screens, Drugs and Vaccines

Editor(s): Conor R. Caffrey

Published Online: 23 AUG 2012

Print ISBN: 9783527330591

Online ISBN: 9783527652969

DOI: 10.1002/9783527652969

Series Editor(s): Paul M. Selzer

About this Book

This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development.
With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and veterinary scientists.

Table of contents

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  1. Part One: Targets

    1. Chapter 3

      Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets (pages 43–59)

      Dhanasekaran Shanmugam, Stuart A. Ralph, Santiago J. Carmona, Gregory J. Crowther, David S. Roos and Fernán Agüero

  2. Part Two: Screens

    1. Chapter 9

      Identification and Profiling of Nematicidal Compounds in Veterinary Parasitology (pages 135–157)

      Andreas Rohwer, Jürgen Lutz, Christophe Chassaing, Manfred Uphoff, Anja R. Heckeroth and Paul M. Selzer

    2. Chapter 11

      Use of Rodent Models in the Discovery of Novel Anthelmintics (pages 181–199)

      Rebecca Fankhauser, Linsey R. Cozzie, Bakela Nare, Kerrie Powell, Ann E. Sluder and Lance G. Hammerland

  3. Part Three: Drugs

    1. Chapter 14

      Antinematodal Drugs – Modes of Action and Resistance: And Worms Will Not Come to Thee (Shakespeare: Cymbeline: IV, ii) (pages 233–249)

      Alan P. Robertson, Samuel K. Buxton, Sreekanth Puttachary, Sally M. Williamson, Adrian J. Wolstenholme, Cedric Neveu, Jacques Cabaret, Claude L. Charvet and Richard J. Martin

    2. Chapter 15

      Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes (pages 251–265)

      Mark J. Taylor, Louise Ford, Achim Hoerauf, Ken Pfarr, Jeremy M. Foster, Sanjay Kumar and Barton E. Slatko

    3. Chapter 18

      Discovery, Mode of Action, and Commercialization of Derquantel (pages 297–307)

      Debra J. Woods, Steven J. Maeder, Alan P. Robertson, Richard J. Martin, Timothy G. Geary, David P. Thompson, Sandra S. Johnson and George A. Conder

  4. Part Four: Vaccines

    1. Chapter 25

      Schistosomiasis Vaccines – New Approaches to Antigen Discovery and Promising New Candidates (pages 421–433)

      Alex Loukas, Soraya Gaze, Mark Pearson, Denise Doolan, Philip Felgner, David Diemert, Donald P. McManus, Patrick Driguez and Jeffrey Bethony

    2. Chapter 29

      Vaccines Against Cestode Parasites (pages 485–503)

      Marshall W. Lightowlers, Charles G. Gauci, Abdul Jabbar and Cristian Alvarez

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