Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties

Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties

Editor(s): Daniel Erik Otzen

Published Online: 27 JAN 2013 05:03AM EST

Print ISBN: 9783527332007

Online ISBN: 9783527654185

DOI: 10.1002/9783527654185

About this Book

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research.

The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

Table of contents

    1. You have free access to this content
    2. Chapter 10

      The Kinetics and Mechanisms of Amyloid Formation (pages 183–209)

      Samuel I. A. Cohen, Michele Vendruscolo, Christopher M. Dobson and Tuomas P. J. Knowles

    3. Chapter 13

      The Role of Aβ in Alzheimer's Disease (pages 263–293)

      Timothy M. Ryan, Blaine R. Roberts, Victor A. Streltsov, Stewart D. Nuttall and Colin L. Masters

    4. Chapter 15

      Fibrillar Polymorphism (pages 321–343)

      Marcus Fändrich, Melanie Wulff, Jesper Søndergaard Pedersen and Prof. Dr. Daniel Otzen

    5. Chapter 18

      Hormone Amyloids in Sickness and in Health (pages 395–410)

      Carolin Seuring, Nadezhda Nespovitaya, Jonas Rutishauser, Martin Spiess and Roland Riek

    6. Chapter 19

      Functional Amyloids in Bacteria (pages 411–438)

      Morten S. Dueholm, Per Halkjaer Nielsen, Matthew Chapman and Prof. Dr. Daniel Otzen

    7. You have free access to this content

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