Bioisosteres in Medicinal Chemistry
Copyright © 2012 Wiley-VCH Verlag GmbH & Co. KGaA
Editor(s): Nathan Brown
Published Online: 3 AUG 2012 05:52AM EST
Print ISBN: 9783527330157
Online ISBN: 9783527654307
Series Editor(s): Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
About this Book
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.
With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.