Trypanosomatid Diseases: Molecular Routes to Drug Discovery

Trypanosomatid Diseases: Molecular Routes to Drug Discovery

Editor(s): Timo Jäger, Oliver Koch, Leopold Flohé

Published Online: 4 APR 2013 04:59AM EST

Print ISBN: 9783527332557

Online ISBN: 9783527670383

DOI: 10.1002/9783527670383

Series Editor(s): Paul M. Selzer

About this Book

This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it
covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.

Table of contents

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  1. Part One: Disease Burden, Current Treatments, Medical Needs, and Strategic Approaches

  2. Part Two: Metabolic Peculiarities in the Trypanosomatid Family Guiding Drug Discovery

    1. Chapter 7

      Function of Glycosomes in the Metabolism of Trypanosomatid Parasites and the Promise of Glycosomal Proteins as Drug Targets (pages 121–151)

      Melisa Gualdrón-López, Paul A. M. Michels, Wilfredo Quiñones, Ana J. Cáceres, Luisana Avilán and Juan-Luis Concepción

    2. Chapter 8

      Glyoxalase Enzymes in Trypanosomatids (pages 153–166)

      Marta Sousa Silva, António E. N. Ferreira, Ricardo Gomes, Ana M. Tomás, Ana Ponces Freire and Carlos Cordeiro

    3. Chapter 14

      Life and Death of Trypanosoma Brucei: New Perspectives for Drug Development (pages 261–277)

      Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Schönfeld, Bruno K. Kubata and Michael Duszenko

  3. Part Three: Validation and Selection of Drug Targets in Kinetoplasts

  4. Part Four: Examples of Target-Based Approaches and Compounds Under Consideration

    1. Chapter 21

      Screening Approaches Towards Trypanothione Reductase (pages 383–404)

      Mathias Beig, Frank Oellien, R. Luise Krauth-Siegel and Prof. Dr. Paul M. Selzer

    2. Chapter 23

      Inhibition of Trypanothione Synthetase as a Therapeutic Concept (pages 429–443)

      Dr. Oliver Koch, Dr. Timo Jäger, Prof. Dr.h.c. Leopold Flohé and Prof. Dr. Paul M. Selzer

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