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Topical Paper
Heme oxygenase, carbon monoxide, and interstitial cells of Cajal
Article first published online: 3 DEC 1999
DOI: 10.1002/(SICI)1097-0029(19991201)47:5<321::AID-JEMT3>3.0.CO;2-J
Copyright © 1999 Wiley-Liss, Inc.
Issue
1097-0029/asset/cover.gif?v=1&s=43ac34a0c5790efa9b3c9852600b3b1d1fb6e338 "Microscopy Research and Technique")
Microscopy Research and Technique
Special Issue: Interstitial Cells of Cajal, Part II
Volume 47, Issue 5, pages 321–324, 1 December 1999
Additional Information
How to Cite
Farrugia, G. and Szurszewski, J. H. (1999), Heme oxygenase, carbon monoxide, and interstitial cells of Cajal. Microscopy Research and Technique, 47: 321–324. doi: 10.1002/(SICI)1097-0029(19991201)47:5<321::AID-JEMT3>3.0.CO;2-J
Publication History
- Issue published online: 3 DEC 1999
- Article first published online: 3 DEC 1999
- Manuscript Accepted: 27 MAY 1999
- Manuscript Received: 27 JAN 1999
Funded by
- National Institutes of Health. Grant Numbers: DK52766, DK17238
- Abstract
- References
- Cited By
Keywords:
- gastrointestinal tract;
- motility;
- potassium channel
Abstract
Interstitial cells of Cajal play a central role in the control of gastrointestinal motility. The mechanisms of communication between interstitial cells of Cajal and smooth muscle cells are to a large extent unknown. This article reviews the potential role of carbon monoxide as a messenger molecule between interstitial cells of Cajal and gastrointestinal smooth muscle cells. The machinery required for the formation of carbon monoxide is present in interstitial cells of Cajal and gastrointestinal smooth muscle cells express a target site of action for carbon monoxide, a potassium channel. Carbon monoxide may, therefore, be produced in interstitial cells of Cajal and function as a messenger molecule between interstitial cells of Cajal and gastrointestinal smooth muscle cells. Microsc. Res. Tech. 47:321–324, 1999. © 1999 Wiley-Liss, Inc.