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Androgen-independent expression of hoxb-13 in the mouse prostate

  1. Taduru Sreenath1,
  2. András Orosz2,
  3. Kazuyuki Fujita3,
  4. Charles J. Bieberich2,*

Article first published online: 11 OCT 1999

DOI: 10.1002/(SICI)1097-0045(19991101)41:3<203::AID-PROS8>3.0.CO;2-J

Issue

The Prostate

The Prostate

Volume 41, Issue 3, pages 203–207, 1 November 1999

Additional Information

How to Cite

Sreenath, T., Orosz, A., Fujita, K. and Bieberich, C. J. (1999), Androgen-independent expression of hoxb-13 in the mouse prostate. The Prostate, 41: 203–207. doi: 10.1002/(SICI)1097-0045(19991101)41:3<203::AID-PROS8>3.0.CO;2-J

Author Information

  1. 1

    Functional Genomics Unit, NIDCR, National Institutes of Health, Bethesda, Maryland

  2. 2

    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland

  3. 3

    Department of Obstetrics and Gynecology, Niigata University School of Medicine, Asahimachi, Japan

*Department of Biological Sciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250

Publication History

  1. Issue published online: 11 OCT 1999
  2. Article first published online: 11 OCT 1999
  3. Manuscript Accepted: 18 AUG 1999
  4. Manuscript Received: 10 JUN 1999

Funded by

  • U.S. Army Medical Research and Materiel Command Prostate Cancer Research Program. Grant Number: DAMD17-98-1-8477

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Keywords:

  • homeobox gene;
  • gene expression;
  • castration;
  • cancer

Abstract

BACKGROUND

Hox genes encode transcriptional regulatory proteins that are largely responsible for establishing the body plan of all metazoan organisms. A subset of Hox genes is expressed during the period of organogenesis and into adulthood. hoxb-13 is a recently-described member of the Hox gene family that is expressed in the spinal cord, hindgut, and urogenital sinus during embryogenesis.

METHODS

Northern blot and in situ hybridization analyses of hoxb-13 expression in adult mouse tissues were performed.

RESULTS

hoxb-13 mRNA is restricted to the prostate gland and distal colon in adult animals. In situ hybridization of mouse prostate tissue demonstrated that hoxb-13 is expressed in the epithelial cells of the ventral, dorsal, lateral, and anterior prostate lobes. Accumulation of hoxb-13 mRNA is not diminished following castration.

CONCLUSIONS

These data demonstrate that hoxb-13 expression is androgen-independent in mouse prostate glands. The identification of hoxb-13 as an androgen-independent gene expressed in adult mouse prostate epithelial cells provides a new potential target for developing therapeutics to treat advanced prostate cancer. Prostate 41:203–207, 1999. © 1999 Wiley-Liss, Inc.

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