1097-0134/asset/PROT_centre.gif?v=1&s=77b56b1f2cdaba74cb3bb149bd9b029cd8803cdb)
Comparison of Prediction Quality in Three CASPS
An attempt to analyse progress in fold recognition from CASP1 to CASP3
Article first published online: 8 NOV 1999
DOI: 10.1002/(SICI)1097-0134(1999)37:3+<226::AID-PROT29>3.0.CO;2-Z
Copyright © 1999 Wiley-Liss, Inc.
Issue
1097-0134/asset/cover.gif?v=1&s=d817e79b67ba6cacf8bdcce1a819c04de300a7e3 "Proteins: Structure, Function, and Bioinformatics")
Proteins: Structure, Function, and Bioinformatics
Supplement: Third Meeting on the Critical Assessment of Techniques for Protein Structure Prediction
Volume 37, Issue Supplement 3, pages 226–230, 1999
Additional Information
How to Cite
Sippl, M. J., Lackner, P., Domingues, F. S. and Koppensteiner, W. A. (1999), An attempt to analyse progress in fold recognition from CASP1 to CASP3. Proteins, 37: 226–230. doi: 10.1002/(SICI)1097-0134(1999)37:3+<226::AID-PROT29>3.0.CO;2-Z
Publication History
- Issue published online: 8 NOV 1999
- Article first published online: 8 NOV 1999
- Manuscript Accepted: 14 JUN 1999
- Manuscript Received: 7 JUN 1999
Funded by
- Fonds zur Förderung der wissenschafltichen Forschung, Austria. Grant Numbers: P11601-GEN, P11205-MOB
- Fundação para a Ciência e a Tecnologia. Grant Number: PRAXIS XXI/BD/4528/94
- Abstract
- Article
- References
- Cited By
Keywords:
- structure comparison;
- structure similarity;
- prediction;
- evaluation
Abstract
The Critical Assessment of Techniques for Protein Structure Prediction (CASP) experiment has been conducted for the third time. An obvious question is whether there has been progress from CASP1 to CASP3. An analysis depends on many variables, including prediction category, number and difficulty of targets, methods used to evaluate prediction success, and the rules for submission. It also depends on whether progress is measured in terms of all predictions submitted or in terms of the best predictions for each target. The progress made by individual groups is another interesting issue. In view of this complexity and the limited amount of data, an objective estimate of progress is difficult to obtain. Despite such difficulties, some estimate of progress is desirable. Here, we present an attempt to quantify progress in the fold-recognition category from CASP1 to CASP3. The numbers indicate clear progress from CASP1 to CASP2 but no improvement from CASP2 to CASP3. However, we argue that the targets in CASP3 are more difficult compared with CASP2, which translates into better performance of CASP3 over CASP2. Proteins Suppl 1999;3:226–230. © 1999 Wiley-Liss, Inc.