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Research Article
Do more complex organisms have a greater proportion of membrane proteins in their genomes?
Article first published online: 11 MAY 2000
DOI: 10.1002/(SICI)1097-0134(20000601)39:4<417::AID-PROT140>3.0.CO;2-Y
Copyright © 2000 Wiley-Liss, Inc.
Issue
1097-0134/asset/cover.gif?v=1&s=d817e79b67ba6cacf8bdcce1a819c04de300a7e3 "Proteins: Structure, Function, and Bioinformatics")
Proteins: Structure, Function, and Bioinformatics
Volume 39, Issue 4, pages 417–420, 1 June 2000
Additional Information
How to Cite
Stevens, T. J. and Arkin, I. T. (2000), Do more complex organisms have a greater proportion of membrane proteins in their genomes?. Proteins, 39: 417–420. doi: 10.1002/(SICI)1097-0134(20000601)39:4<417::AID-PROT140>3.0.CO;2-Y
Publication History
- Issue published online: 11 MAY 2000
- Article first published online: 11 MAY 2000
- Manuscript Accepted: 4 FEB 2000
- Manuscript Received: 5 OCT 1999
Funded by
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- Abstract
- Article
- References
- Cited By
Keywords:
- proteome;
- protein sequence;
- α-helix;
- hydrophobicity;
- hydropathy
Abstract
One may speculate that higher organisms require a proportionately greater abundance of membrane proteins within their genomes in order to furnish the requirements of differentiated cell types, compartmentalization, and intercellular signalling. With the recent availability of several complete prokaryotic genome sequences and sufficient progress in many eukaryotic genome sequencing projects, we seek to test this hypothesis. Using optimized hydropathy analysis of proteins in several, diverse proteomes, we show that organisms of the three domains of life—Eukarya, Eubacteria, and Archaea—have similar proportions of α-helical membrane proteins within their genomes and that these are matched by the complexity of the aqueous components. Proteins 2000;39:417–420. © 2000 Wiley-Liss, Inc.