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Cancer

Cover image for Cancer

15 January 1997

Volume 79, Issue 2

Pages 203–423

  1. Tributes

    1. Top of page
    2. Tributes
    3. Original Articles
    4. Communications
    5. Errata
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      Maurice M. Black, M.D. : In memoriam (pages 203–205)

      Reinhard E. Zachrau

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<203::AID-CNCR1>3.0.CO;2-L

  2. Original Articles

    1. Top of page
    2. Tributes
    3. Original Articles
    4. Communications
    5. Errata
    1. Anatomic Site

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      Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma : Association with angiogenesis and tumor progression (pages 206–213)

      Kimitoshi Inoue, Yuichi Ozeki, Toshiyuki Suganuma, Yoshiaki Sugiura and Susumu Tanaka

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<206::AID-CNCR2>3.0.CO;2-I

      Vascular endothelial growth factor (VEGF) expression and microvessel density were examined in 75 primary esophageal squamous cell carcinomas. VEGF expression was found to be associated with tumor progression and poor prognosis by stimulating angiogenesis in esophageal squamous cell carcinoma.

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      Direct measurement of doxorubicin concentration in the intact, living single cancer cell during hyperthermia (pages 214–219)

      Hideki Kawai, Yoshihiro Minamiya, Michihiko Kitamura, Ikuo Matsuzaki, Masaji Hashimoto, Hiroyuki Suzuki and Shichisaburo Abo

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<214::AID-CNCR3>3.0.CO;2-K

      The authors developed a new method for measuring the doxorubicin concentration in the intact, living single cancer cell. They found that hyperthermia increases doxorubicin uptake in the nucleus of the cancer cell.

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      Tumor vascularity correlates with the prognosis of patients with esophageal squamous cell carcinoma (pages 220–225)

      Nobuhiko Tanigawa, Mitsuyoshi Matsumura, Hirokazu Amaya, Akihiro Kitaoka, Takumi Shimomatsuya, Caide Lu, Ryusuke Muraoka and Takeo Tanaka

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<220::AID-CNCR4>3.0.CO;2-O

      The extent of tumor vascularity, assessed with either von Willebrand factor or CD34 staining, is closely related to the overall survival of patients with esophageal squamous cell carcinoma.

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      Gene amplification and proliferative kinetics in relation to prognosis of patients with gastric carcinoma (pages 226–232)

      Dino Amadori, Marco Maltoni, Annalisa Volpi, Oriana Nanni, Emanuela Scarpi, Beatrice Renault, Natalia S. Pellegata, Michele Gaudio, Enrico Magni and Guglielmina N. Ranzani

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<226::AID-CNCR5>3.0.CO;2-I

      The amplification of c-myc, c-K-ras, and hst oncogenes in a series of 124 gastric carcinomas did not reveal any new independent prognostic factor. On the contrary, amplification of c-erb B-2 had a significant negative impact on overall survival. An examination of the tumors involving the thymidine labeling index highlighted the need to identify the most suitable biologic material for estimating proliferative activity in gastric carcinoma.

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      The significance of allelic deletions and aneuploidy in colorectal carcinoma : Results of a 5-year follow-up study (pages 233–244)

      Kenneth H. Cohn, Deborah L. Ornstein, Fusheng Wang, Fidelina DeSoto LaPaix, Kathy Phipps, Cheryl Edelsberg, Rosemary Zuna, Leila A. Mott and John L. Dunn

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<233::AID-CNCR6>3.0.CO;2-L

      Patients with nm23-H1 allelic deletions are 3 times as likely to develop distant metastases as patients without nm23-H1 deletions (relative risk, 3.89; 95% confidence interval, 1.39, 10.89; P = 0.01).

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      Osteogenic sarcoma of the extremity with detectable lung metastases at presentation : Results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions (pages 245–254)

      Gaetano Bacci, Mario Mercuri, Antonio Briccoli, Stefano Ferrari, Franco Bertoni, Davide Donati, Carlo Monti, Antonio Zanoni, Cristiana Forni and Marco Manfrini

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<245::AID-CNCR7>3.0.CO;2-J

      With aggressive primary chemotherapy followed by simultaneous resection of the primary and metastatic tumor, it is possible to improve the prognosis of patients presenting with osteosarcoma of the extremity with lung metastases.

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      Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging (pages 255–261)

      Shigeki Yamamura, Keiji Sato, Hideshi Sugiura, Hirohisa Katagiri, Yoko Ando, Hiroshi Fukatsu and Hisashi Iwata

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<255::AID-CNCR8>3.0.CO;2-J

      The peritumoral edema accompanying primary bone tumors demonstrated by magnetic resonance imaging correlated with the tumor prostaglandin level. Recognition of this phenomenon is advantageous not only for the diagnostic process but also for understanding the characteristic features of individual primary bone tumors.

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      Behçet's disease associated with myelodysplastic syndromes : A case report and a review of the literature (pages 262–268)

      Eiji Ohno, Eiichi Ohtsuka, Kouichirou Watanabe, Toshirou Kohno, Kaori Takeoka, Yoshio Saburi, Hiroshi Kikuchi and Masaru Nasu

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<262::AID-CNCR9>3.0.CO;2-M

      A case of Behçet's disease associated with myelodysplastic syndromes is described and other published cases reviewed. Trisomy 8 was the predominant cytogenetic abnormality in these cases.

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      Anti-HTLV-1 antibody positive cutaneous T-cell lymphoma (pages 269–274)

      Arata Kikuchi, Yoshiyuki Ohata, Hiroko Matsumoto, Makoto Sugiura and Takeji Nishikawa

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<269::AID-CNCR10>3.0.CO;2-Z

      Adult T-cell leukemia/lymphoma should be differentiated from cutaneous T-cell lymphoma in view of the responsibility of human T-lymphotropic virus type 1 for promoting or maintaining cutaneous T-cell lymphoma.

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      Cutaneous malignant melanoma in southern Sweden 1965, 1975, and 1985 : Prognostic factors and histologic correlations (pages 275–283)

      Anna Måsbäck, Johan Westerdahl, Christian Ingvar, Håkan Olsson and Nils Jonsson

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<275::AID-CNCR11>3.0.CO;2-Y

      The current study is a population-based study of invasive cutaneous malignant melanoma in southern Sweden. Prognostic factors in the years 1965, 1975, and 1985 were used in a multivariate analysis adjusting for age, tumor thickness, gender, and ulceration.

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      Interphase cytogenetic analysis of myxoid soft tissue tumors by fluorescence in situ hybridization and DNA flow cytometry using paraffin-embedded tissue (pages 284–293)

      Takatoshi Aoki, Masanori Hisaoka, Hiromi Kouho, Hiroshi Hashimoto and Hajime Nakata

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<284::AID-CNCR12>3.0.CO;2-X

      Fluorescence in situ hybridization analysis can be used on paraffin embedded materials, and is a useful method for differentiating myxoid liposarcomas from other myxoid soft tissue tumors.

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      Follicular dendritic cell sarcoma : Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized (pages 294–313)

      John K. C. Chan, Christopher D. M. Fletcher, Simon J. Nayler and Kum Cooper

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<294::AID-CNCR13>3.0.CO;2-W

      To the authors' knowledge, this is the largest series to date of follicular dendritic cell sarcoma with the longest follow-up, detailing the clinicopathologic features of 17 patients, in 2 of whom the tumor was associated with Castleman's disease. The malignant potential of this tumor has previously been underestimated, and intraabdominal tumors consistently pursue an aggressive course.

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      The influence of black race and socioeconomic status on the use of breast-conserving surgery for medicare beneficiaries (pages 314–319)

      Tracy A. Michalski and Ann Butler Nattinger

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<314::AID-CNCR14>3.0.CO;2-3

      In a study of Medicare beneficiaries age 65–79 years, black women and women of lower socioeconomic status (SES) were less likely to undergo breast-conserving surgery. However, the reduced use of breast-conserving surgery in black women appears attributable to SES.

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      Progestin alone as primary treatment of endometrial carcinoma in premenopausal women : Report of seven cases and review of the literature (pages 320–327)

      Young B. Kim, Christine H. Holschneider, Kris Ghosh, Roberta K. Nieberg and Fredrick J. Montz

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<320::AID-CNCR15>3.0.CO;2-2

      Premenopausal women with endometrial carcinoma may be treated successfully with progestin alone as primary therapy in order to preserve fertility potential.

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      Radiotherapy for localized prostate carcinoma : The correlation of pretreatment prostate specific antigen and nadir prostate specific antigen with outcome as assessed by systematic biopsy and serum prostate specific antigen (pages 328–336)

      Juanita M. Crook, Yasir A. Bahadur, R. Gregory Bociek, Gad A. Perry, Susan J. Robertson and Bernd A. Esche

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<328::AID-CNCR16>3.0.CO;2-2

      Systematic prostate biopsies, performed as part of the rigorous follow-up of prostate carcinoma patients after radiotherapy, define the patterns of failure and confirm the prognostic value of pretreatment prostate specific antigen (PSA), postradiotherapy nadir PSA, and T classification. Prior to treatment, pretreatment PSA is the overwhelming independent predictor of failure, but it is surpassed by postradiotherapy nadir PSA when that factor is added to the model.

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      A multiple prognostic index predictive of disease outcome after irradiation for clinically localized prostate carcinoma (pages 337–344)

      Thomas M. Pisansky, Michael J. Kahn, Gregory M. Rasp, Stephen S. Cha, Michael G. Haddock and David G. Bostwick

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<337::AID-CNCR17>3.0.CO;2-1

      The combination of pretherapy clinical tumor stage, Gleason score, and PSA level can be used to obtain improved estimates of the risk for disease relapse in patients treated solely with RT for clinically localized prostate carcinoma. Risk estimate plots of this type may facilitate exchange of therapeutic outcome information, be instrumental in pretherapy decision-making for the new patient with this condition, and aid in the selection of patients for future studies.

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      Residual pulmonary masses after chemotherapy for metastatic nonseminomatous germ cell tumor : Prediction of histology (pages 345–355)

      Ewout W. Steyerberg, H. Jan Keizer, Jonathan E. Messemer, Guy C. Toner, Heimen Schraffordt Koops, Sophie D. Fosså, Arthur Gerl, Dirk T. Sleijfer, John P. Donohue, J. Dik F. Habbema and for the ReHiT Study Group

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<345::AID-CNCR18>3.0.CO;2-0

      The results of this study indicated subgroups of patients with a high probability of necrosis and a low risk of cancer in residual pulmonary masses. For their analysis, the authors used readily available preoperative patient characteristics, such as primary histology, prechemotherapy tumor marker values, and reduction in mass size. The strongest predictor of the pulmonary histology was the retroperitoneal lymph node histology, which implied that retroperitoneal resection should be performed before thoracotomy is considered.

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      Small cell neuroendocrine carcinoma of the urinary bladder : A clinicopathologic study with emphasis on cytologic features (pages 356–361)

      Syed Z. Ali, Victor E. Reuter and Maureen F. Zakowski

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<356::AID-CNCR19>3.0.CO;2-#

      Primary small cell neuroendocrine carcinoma of the urinary bladder must be distinguished from transitional cell carcinoma and can be accurately diagnosed in urine cytology. Key cytologic features and immunocytochemistry are discussed.

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      Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine (pages 362–369)

      Kazuhiro Yoshida, Takashi Sugino, Hidetoshi Tahara, Anthony Woodman, John Bolodeoku, Vinod Nargund, Griff Fellows, Steven Goodison, Eiichi Tahara and David Tarin

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<362::AID-CNCR20>3.0.CO;2-Y

      Telomerase activity was detected in 86% of bladder carcinoma tissues examined and its application to the detection of noninvasive bladder carcinoma investigated.

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      Supratentorial World Health Organization Grade 2 astrocytomas and oligoastrocytomas : A new pattern of prognostic factors (pages 370–379)

      Friedrich W. Kreth, Michael Faist, Reinhard Rossner, Benedikt Volk and Christoph B. Ostertag

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<370::AID-CNCR21>3.0.CO;2-X

      Prognostic factors for survival and malignant transformation in supratentorial World Health Organization Grade 2 astrocytomas and oligoastrocytomas include interaction of gender and age and tumor volume.

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      Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression (pages 380–389)

      Jan A. Åkervall, Rob J. A. M. Michalides, Hiroyuki Mineta, Alfons Balm, Åke Borg, Michael R. Dictor, Yuesheng Jin, Barbara Loftus, Fredrik Mertens and Johan P. Wennerberg

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<380::AID-CNCR22>3.0.CO;2-W

      Overexpression of cyclin D1 and 11q13 rearrangements are independent prognostic factors for patients with squamous cell carcinoma of the head and neck. However, other genetic mechanisms besides amplification of CCND1 result in deregulation of cyclin D1. Oncogenes at 11q13 as well as CCND1 may be involved in the tumorigenesis.

    22. General Topic

      Lymphoma, Extranodal
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      Gastric lymphomas compared with lymph node lymphomas in a population-based registry differ in stage distribution and dissemination patterns but not in patient survival (pages 390–397)

      Augustinus D. Krol, Jo Hermans, Mark H. Kramer, Philip M. Kluin, Hanneke C. Kluin-Nelemans, Paul Blok, Karel J. Heering, Evert M. Noordijk and J. Han van Krieken

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<390::AID-CNCR23>3.0.CO;2-V

      A comparison of patients with gastric non-Hodgkin's lymphoma with patients with lymph node non-Hodgkin's lymphoma in a population-based registry revealed that primary gastric lymphomas of mucosa-associated lymphoid tissue (MALT) type have a restricted pattern of dissemination, which gives support to the concept that MALT lymphomas are a separate entity.

    23. Paraganglioma, Extraadrenal, Pigmented
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      Pigmented extraadrenal paragangliomas : A clinicopathologic and immunohistochemical study of five cases (pages 398–402)

      Cesar A. Moran, Jorge Albores-Saavedra, Bruce M. Wenig and Hernando Mena

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<398::AID-CNCR24>3.0.CO;2-V

      A study of five cases of pigmented paragangliomas emphasizes the need to distinguish these tumors from other more aggressive neoplasms.

    24. Pediatric Oncology
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      Brain metastases in children with solid tumors (pages 403–410)

      Eric Bouffet, Nasser Doumi, Philippe Thiesse, Carmine Mottolese, Anne Jouvet, Michel Lacroze, Christian Carrie, Didier Frappaz and Maud Brunat-Mentigny

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<403::AID-CNCR25>3.0.CO;2-3

      The introduction of effective systemic chemotherapy has changed the patterns of brain metastases in children. The increasing incidence of brain metastases in patients with sarcoma and neuroblastoma suggests that the brain is a pharmacologically protected site in patients with advanced disease at diagnosis.

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      Neoadjuvant chemotherapy for pediatric osteosarcoma patients (pages 411–415)

      Atsumasa Uchida, Akira Myoui, Nobuto Araki, Hideki Yoshikawa, Yoshitaka Shinto and Takafumi Ueda

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<411::AID-CNCR26>3.0.CO;2-2

      The survival rates of 3 different chemotherapy regimens were analyzed in 67 pediatric osteosarcoma patients. Dose intensity and early administration of the regimen were found to be important factors for long term survival.

  3. Communications

    1. Top of page
    2. Tributes
    3. Original Articles
    4. Communications
    5. Errata
    1. International Union Against Cancer Study Group on Basic and Clinical Cancer Research

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      Multigene effects influencing each other (pages 416–419)

      Max M. Burger and Stephen Friend

      Article first published online: 27 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970115)79:2<416::AID-CNCR27>3.0.CO;2-2

      The International Union Against Cancer Study Group discussed the multigenic aspect of oncogenesis and differentiation.

  4. Errata

    1. Top of page
    2. Tributes
    3. Original Articles
    4. Communications
    5. Errata
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    2. You have free access to this content

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