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Cancer

Cover image for Cancer

15 March 1997

Volume 79, Issue 6

Pages 1061–1268

  1. Editorials

    1. Top of page
    2. Editorials
    3. Original Articles
    4. Communications
    1. Counterpoint

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      Postmastectomy radiation : A modest benefit prevails for high risk patients (pages 1061–1066)

      Barbara Fowble

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1061::AID-CNCR1>3.0.CO;2-J

      In high risk patients, postmastectomy adjuvant radiation results in a significant decrease in isolated locoregional failure as a first event, as well as a modest prolongation of median survival. However, the randomized trial by the Eastern Cooperative Oncology Group, described in the article by Olson et al. in this issue, was not designed to demonstrate statistical significance for the benefit observed.

      See also pages 1067–1068 and 1138–1149.

    2. Reply to Counterpoint

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      Postmastectomy radiation : A modest benefit prevails for high risk patients—reply (pages 1067–1068)

      John E. Olson and Donna Neuberg

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1067::AID-CNCR2>3.0.CO;2-D

      See also pages 1061-1066 and 1138-1149.

  2. Original Articles

    1. Top of page
    2. Editorials
    3. Original Articles
    4. Communications
    1. Anatomic Site

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      Immunohistochemical evaluation of lymph node micrometastases from gastric carcinomas (pages 1069–1076)

      Kimitaka Ishida, Tsutomu Katsuyama, Atsushi Sugiyama and Seiji Kawasaki

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1069::AID-CNCR3>3.0.CO;2-B

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      The presence of micrometastases in lymph nodes is an indispensable factor in determining the prognosis of gastric carcinoma patients. It also relates to the histologic type of the disease.

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      Synchronous and metachronous primary gastric lymphoma and adenocarcinoma : A clinicopathologic study of 12 patients (pages 1077–1085)

      Shotaro Nakamura, Kunihiko Aoyagi, Shin-ichi Iwanaga, Takashi Yao, Masazumi Tsuneyoshi and Masatoshi Fujishima

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1077::AID-CNCR4>3.0.CO;2-D

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      The development of double primary gastric lymphoma and adenocarcinoma in the same patient is considered to be closely associated with Helicobacter pylori, but rarely with an Epstein-Barr virus infection. Lymphomas may precede carcinogenesis, and the prognosis thus appears to depend more on the adenocarcinoma rather than on the lymphoma.

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      Carcinoids of the jejunum and ileum : An immunohistochemical and clinicopathologic study of 167 cases (pages 1086–1093)

      Allen P. Burke, Rebecca M. Thomas, Al M. Elsayed and Leslie H. Sobin

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1086::AID-CNCR5>3.0.CO;2-E

      Carcinoid tumors of the jejunum and ileum differ from those arising in other gastrointestinal sites. Five-year survival is 58%, and negative prognostic features include distant metastasis at the time of surgery, presence of carcinoid syndrome, and female gender.

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      Bimonthly high dose leucovorin and 5-fluorouracil 48-hour infusion with interferon-alpha-2a in patients with advanced colorectal carcinoma (pages 1094–1099)

      Christophe Tournigand, Christophe Louvet, Aimery de Gramont, Elisabeth Lucchi, Jean-François Seitz, Frédéric Mal, Eric Raymond, Jean Cady, Elisabeth Carola, Marcel Krulik and for the Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD)

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1094::AID-CNCR6>3.0.CO;2-G

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      In a first-line Phase II study, a bimonthly regimen of high dose leucovorin, a high dose 48-hour infusion of 5-FU, and interferon-alpha-2a was administered to 50 patients with advanced colorectal carcinoma. This regimen produced a 44% overall response rate, a median progression free survival of 9 months, and a median survival of 25 months. 42% of patients experienced Grade 3 or 4 toxicity.

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      Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma (pages 1100–1105)

      Karine Beerblock, Yves Rinaldi, Thierry André, Christophe Louvet, Eric Raymond, Christophe Tournigand, Elisabeth Carola, Roger Favre, Aimery de Gramont, Marcel Krulik and for the Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD)

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1100::AID-CNCR7>3.0.CO;2-J

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      In a first-line Phase II study, a bimonthly regimen of a high dose of leucovorin and a high dose 48-hour infusion of 5-fluorouracil were administered to 101 patients with advanced colorectal carcinoma; this regimen produced a 33.7% overall response rate, a median progression free survival of 8 months, and a median survival of 18 months. Only 15% of the patients experienced Grade 3 or 4 toxicity.

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      Activation of the K-ras oncogene in colorectal neoplasms is Associated with decreased apoptosis (pages 1106–1113)

      Robyn L. Ward, Alison V. Todd, Fernando Santiago, Terence O'Connor and Nicholas J. Hawkins

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1106::AID-CNCR8>3.0.CO;2-D

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      Rates of apoptosis in colorectal neoplasms were assessed with respect to the K-ras status of the tumor, as well as other factors known to influence apoptotic cell death. These findings suggest that activation of the K-ras oncogene inhibits the rate of apoptosis in colorectal neoplasms.

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      Molecular and immunohistochemical analysis of the bcl-1/cyclin D1 gene in laryngeal squamous cell carcinomas : Correlation of protein expression with lymph node metastases and advanced clinical stage (pages 1114–1121)

      Nicola S. Fracchiolla, Giancarlo Pruneri, Lorenzo Pignataro, Nadia Carboni, Pasquale Capaccio, Alketa Boletini, Roberto Buffa and Antonino Neri

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1114::AID-CNCR9>3.0.CO;2-F

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      The authors found cyclin D1 gene amplification and expression in a significant subset of laryngeal squamous cell carcinomas. This suggested that the deregulation of the cyclin D1 gene is involved in the pathogenesis of these tumors.

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      Classification of localized melanoma by the exponential survival trees method (pages 1122–1128)

      Xin Huang, Seng-jaw Soong, William H. McCarthy, Marshall M. Urist and Charles M. Balch

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1122::AID-CNCR10>3.0.CO;2-1

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      The authors generated a comprehensive risk grouping system that uses the exponential survival trees method to classify cases of localized melanoma based on three prognostic factors.

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      High dose tumor necrosis factor-α and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation (pages 1129–1137)

      Mordechai Gutman, Moshe Inbar, Dina Lev-Shlush, Subhi Abu-Abid, Martha Mozes, Samario Chaitchik, Itzhak Meller and Joseph M. Klausner

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1129::AID-CNCR11>3.0.CO;2-1

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      Thirty-five patients with locally advanced soft tissue sarcoma confined to the limb were treated with high dose recombinant tumor necrosis factor-α and melphalan via isolated limb perfusion. All patients were candidates for amputation or other mutilating surgery. The response rate was 91%, with a 37% complete response rate. Limb salvage was achieved in 29 of 34 patients (85%).

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      The role of radiotherapy in the management of operable locally advanced breast carcinoma : Results of a randomized trial by the Eastern Cooperative Oncology Group (pages 1138–1149)

      John E. Olson, Donna Neuberg, Kishan J. Pandya, Melvyn P. Richter, Lawrence J. Solin, Kennedy W. Gilchrist, Douglass C. Tormey, Michael Veeder and Geoffrey Falkson

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1138::AID-CNCR12>3.0.CO;2-0

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      Radiotherapy for locally advanced breast carcinoma, following total mastectomy, axillary dissection, and adjuvant systemic therapy, reduces locoregional recurrence but has no effect on disease free or overall survival.

      See also pages 1061–1066 and 1067–1068.

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      Chemotherapy-induced neutropenia and fever in patients with metastatic breast carcinoma receiving salvage chemotherapy (pages 1150–1157)

      Zia Rahman, Laura Esparza-Guerra, Hwee-Yong Yap, Giuseppe Fraschini, Gerald Bodey and Gabriel Hortobagyi

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1150::AID-CNCR13>3.0.CO;2-Z

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      For patients with metastatic breast carcinoma receiving salvage chemotherapy, the risk of fever increases with decreasing absolute neutrophil count (ANC), but the risk of infection does not increase significantly until ANC decreases to less than 250/μL. Poor performance status, initial courses of chemotherapy, and bone marrow metastases further increase the risk of fever, infection, and mortality.

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      nm23—Relationship to the metastatic potential of breast carcinoma cell lines, primary human xenografts, and lymph node negative breast carcinoma patients (pages 1158–1165)

      Rosalind Lee Russell, Kim R. Geisinger, Rajeshwari R. Mehta, Wain L. White, Brent Shelton and Timothy Edward Kute

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1158::AID-CNCR14>3.0.CO;2-Z

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      Analyses of the levels of nm23 protein were performed on breast tumor cell lines, xenografts, and a retrospective lymph node negative breast carcinoma population using immunohistochemical and/or Western blot methods. No significant correlation was observed between the levels of nm23 and the metastatic potential of these breast tumor populations.

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      Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma (pages 1166–1171)

      Sari Siegfried, Fredrika Pekonen, Tuulikki Nyman, Martti Ämmälä and Eeva-Marja Rutanen

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1166::AID-CNCR15>3.0.CO;2-Y

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      Keratinocyte growth factor (KGF), KGF receptor (KGFR), and fibroblast growth factor receptor-2 (FGFR-2) mRNA are expressed in endometrial adenocarcinoma and in carcinosarcoma tissues. The relative level of KGF mRNA expression in endometrial adenocarcinoma is significantly lower compared with normal cycling endometrium, whereas no difference is found in KGFR mRNA levels between these tissues.

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      Prostatic intraepithelial neoplasia in surgical resections : Relationship to coexistent adenocarcinoma and atypical adenomatous hyperplasia of the prostate (pages 1172–1179)

      Fredrik J. Skjørten, Aasmund Berner, Sverre Harvei, Trude E. Robsahm and Steinar Tretli

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1172::AID-CNCR16>3.0.CO;2-X

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      A detailed study of 1135 nonselected prostate specimens, mainly surgical resections representative of a white urban population, showed high grade prostatic intraepithelial neoplasia (PIN) to be associated with coincident carcinoma. The mean age of patients with prostate carcinoma was 3.9 years higher than for patients without carcinoma, but was not influenced by coexistent PIN.

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      Doxorubicin sensitizes human bladder carcinoma cells to Fas-mediated cytotoxicity (pages 1180–1189)

      Youichi Mizutani, Yusaku Okada, Osamu Yoshida, Manabu Fukumoto and Benjamin Bonavida

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1180::AID-CNCR17>3.0.CO;2-W

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      Treatment with a combination of anti-Fas monoclonal antibody and doxorubicin resulted in a synergistic cytotoxicity against both established and freshly derived bladder carcinoma cells. The up-regulation of Fas antigen expression by doxorubicin might be one of the mechanisms responsible for the synergistic cytotoxicity.

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      Expression of platelet-derived endothelial cell growth factor in bladder carcinoma (pages 1190–1194)

      Youichi Mizutani, Yusaku Okada and Osamu Yoshida

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1190::AID-CNCR18>3.0.CO;2-V

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      The level of platelet-derived endothelial cell growth factor (PDECGF) expression correlated with both stage and a higher grade of bladder carcinoma. Elevated PDECGF expression predicted early recurrence in Ta bladder carcinoma.

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      Descriptive epidemiology of cerebral gliomas in France (pages 1195–1202)

      Agnès Fleury, François Menegoz, Pascale Grosclaude, Jean-Pierre Daures, Michel Henry-Amar, Nicole Raverdy, Paul Schaffer, Michel Poisson and Jean-Yves Delattre

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1195::AID-CNCR19>3.0.CO;2-V

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      The epidemiologic data of cerebral gliomas registered in France between 1983 and 1990 were analyzed. The incidence rate by histologic type, age, and gender as well as the variation of the incidence during the study period were calculated. An increasing trend of 5% per year for malignant astrocytomas in patients older than 65 years was found.

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      High risk of breast carcinoma after irradiation of young women with Hodgkin's disease (pages 1203–1210)

      Alan C. Aisenberg, Dianne M. Finkelstein, Karen P. Doppke, Frederick C. Koerner, Jean-François Boivin and Christopher G. Willett

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1203::AID-CNCR20>3.0.CO;2-2

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      Young women irradiated for Hodgkin's disease require meticulous follow-up for breast carcinoma, particularly in the second and third decades after treatment. In a cohort of 111 women presenting with localized Hodgkin's disease between 1964 and 1984, the actuarial risk of breast carcinoma 25 years after irradiation was 34% for those younger than age 20 years when treated and 22% for those age 20 through 29 years at the time of treatment.

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      Hypercalcemia may indicate Richter's syndrome : Report of four cases and review (pages 1211–1215)

      Johann Beaudreuil, Olivier Lortholary, Antoine Martin, Jean Feuillard, Loïc Guillevin, Pierre Lortholary, Martine Raphael and Philippe Casassus

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1211::AID-CNCR21>3.0.CO;2-1

      Hypercalcemia arising during the course of a low grade lymphoproliferative disorder may be a sign of Richter's syndrome.

    20. General Topic

      Antiemetic Therapy
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      Randomized, double blind, dose-response trial across four oral doses of dolasetron for the prevention of acute emesis after moderately emetogenic chemotherapy (pages 1216–1224)

      Edward B Rubenstein, Richard J. Gralla, John D. Hainsworth, Paul J. Hesketh, Thomas H. Grote, Manuel R. Modiano, Ali Khojasteh, Leonard A. Kalman, Claude R. Benedict, William F. Hahne and for the Oral Dolasetron Dose-Response Study Group

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1216::AID-CNCR22>3.0.CO;2-1

      This randomized, double blind, dose-ranging study demonstrates that oral dolasetron is safe and effective in preventing acute nausea and emesis related to moderately emetogenic chemotherapy. The complete response rate was 61%.

    21. Chemotherapy
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      Differential activity of cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro (pages 1225–1233)

      Katalin Csóka, Sumeer Dhar, Helena Fridborg, Rolf Larsson and Peter Nygren

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1225::AID-CNCR23>3.0.CO;2-0

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      Cremophor EL, the excipient for Taxol, a clinical preparation of paclitaxel, contributes to the efficacy of Taxol in vitro.

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      A pilot study on the use of the proMACE-cytaBOM regimen as a first-line treatment of advanced follicular non-Hodgkin's lymphoma (pages 1234–1240)

      Luca Baldini, Andrea Guffanti, Paolo Gobbi, Mariangela Colombi, Massimo Federico, Paolo Avanzini, Luigi Cavanna, Carla Pieresca, Vittorio Silingardi, Anna T. Maiolo and for the Gruppo Italiano per lo Studio dei Linfomi

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1234::AID-CNCR24>3.0.CO;2-#

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      This study indicates that ProMACE-CytaBOM is a suitable regimen for the first-line treatment of adult patients with advanced follicular non-Hodgkin's lymphoma. In 36 evaluable patients, after a median follow-up of 49 months, the complete response rate was 55.5%, and the rate of relapse free survival was 60%.

    23. Pediatric Oncology
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      Cure of recurrent medulloblastoma : The contribution of surgical resection at relapse (pages 1241–1247)

      Judith Balter-Seri, Celia Mor, Avinoam Shuper, Rina Zaizov and Ian J. Cohen

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1241::AID-CNCR25>3.0.CO;2-Z

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      A case is reported of recurrent medulloblastoma cured by surgery alone. A review of the literature suggests that reoperation is a requisite for cure.

  3. Communications

    1. Top of page
    2. Editorials
    3. Original Articles
    4. Communications
    1. International Union Against Cancer

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      International Union Against Cancer, Committee on International Collaborative Activities : Workshop on the development of a European cancer data base (pages 1248–1253)

      Louis Denis, Gerald P. Murphy and Committee on International Collaborative

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1248::AID-CNCR26>3.0.CO;2-Z

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      Thanks to authors and peer reviewers (pages 1254–1268)

      Version of Record online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970315)79:6<1254::AID-CNCR27>3.0.CO;2-Y

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