Anatomic Site
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Induction chemotherapy followed by radiotherapy versus radiotherapy alone in patients with advanced nasopharyngeal carcinoma : Results of a matched cohort study (pages 1279–1286)Fady B. Geara, Bonnie S. Glisson, Giuseppe Sanguineti, Susan L. Tucker, Adam S. Garden, K. Kian Ang, Scott M. Lippman, Gary L. Clayman, Helmuth Goepfert, Lester J. Peters and Waun K. Hong
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1279::AID-CNCR2>3.0.CO;2-C
Compared with radiotherapy alone, the combination of induction cisplatin and 5-fluorouracil chemotherapy followed by radiation therapy reduced distant metastases and improved survival of patients with locoregionally advanced nasopharyngeal carcinoma.
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Expression of bcl-2 protein in esophageal squamous cell carcinomas and its association with lymph node metastasis (pages 1287–1293)Makoto Ohbu, Makoto Saegusa, Nobuyuki Kobayashi, Hideto Tsukamoto, Hironobu Mieno, Akira Kakita and Isao Okayasu
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1287::AID-CNCR3>3.0.CO;2-E
bcl-2 expression is associated with reduced metastasis to lymph nodes and may be linked with improved survival.
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Carcinoid tumors of the rectum : Effect of size, histopathology, and surgical treatment on metastasis free survival (pages 1294–1298)Aaryan N. Koura, Geoffrey G. Giacco, Steven A. Curley, John M. Skibber, Barry W. Feig and Lee M. Ellis
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1294::AID-CNCR4>3.0.CO;2-H
The clinical course, effect of surgical treatment, and tumor histopathologic characteristics were evaluated in 44 patients presenting with rectal carcinoid tumors at one cancer center between 1955 and 1994. Tumors > 2 cm and tumors > 1 cm with atypical histology were almost always associated with metastasis. Radical surgery did not increase metastasis free survival.
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N-terminal peptide of Type III procollagen : A possible predictor of colorectal carcinoma recurrence (pages 1299–1303)Mario Plebani, Daniela Basso, Giovanni Roveroni, Massimo De Paoli, Fabrizio Galeotti and Augusto Corsini
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1299::AID-CNCR5>3.0.CO;2-C
The N-terminal peptide of Type III procollagen measured in the sera before and 3 months after surgery for colorectal carcinoma, together with stage, was found to be a predictor of recurrence.
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Evidence of clonal divergence in colorectal carcinoma (pages 1304–1314)Rob A. E. M. Tollenaar, Bert A. Bonsing, Nel J. Kuipers-Dijkshoorn, Jo Hermans, Cornelis J. H. van de Velde, Cees J. Cornelisse and Gert Jan Fleuren
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1304::AID-CNCR6>3.0.CO;2-G
Based on a large series of tumor samples, this article describes a model of DNA ploidy changes in all stages of colorectal carcinoma. It shows the emergence of DNA aneuploidy and clonal divergence during the transition from adenoma to carcinoma and describes a different DNA index distribution in hematogenous metastases as compared with the primary colorectal tumors.
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The efficacy of laparoscopic staging in patients with upper gastrointestinal tumors (pages 1315–1319)Els J. M. Nieveen van Dijkum, Laurens Th. de Wit, Otto M. van Delden, Erik A. J. Rauws, Jan J. B. van Lanschot, Hugo Obertop and Dirk J. Gouma
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1315::AID-CNCR7>3.0.CO;2-F
Although the major advantage of diagnostic laparoscopy for patients with a gastrointestinal tumor is prevention of laparotomies, the question remains whether late laparotomies during follow-up are also prevented. In this study, the long term benefit of laparoscopic staging was obvious for patients with proximal bile duct tumors, liver tumors, and pancreatic body and tail tumors, but patients with esophageal tumors did not benefit from laparoscopic staging.
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p53 alteration and human papilloma virus infection in paranasal sinus cancer (pages 1320–1328)Salvatore M. Caruana, Neil Zwiebel, Rubina Cocker, Steven A. McCormick, Robert C. Eberle and Philip Lazarus
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1320::AID-CNCR8>3.0.CO;2-K
This study suggests that alterations in the p53 tumor suppressor gene or protein or infection by human papilloma virus may be predictive of risk for malignant degeneration of paranasal sinus tumors.
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Altered retinoblastoma protein expression in nonsmall cell lung cancer : Its synergistic effects with altered ras and p53 protein status on prognosis (pages 1329–1337)Hirotoshi Dosaka-Akita, Shi-Xue Hu, Michihiro Fujino, Masao Harada, Ichiro Kinoshita, Hong-Ji Xu, Noboru Kuzumaki, Yoshikazu Kawakami and William F. Benedict
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1329::AID-CNCR9>3.0.CO;2-B
Positive or negative retinoblastoma (Rb) protein expression alone, as measured by immunohistochemical analysis, was not correlated with survival or prognosis in this cohort of patients with nonsmall cell lung cancer. However, combined immunohistochemical analysis of Rb and ras p21 and of Rb and p53 proteins demonstrated that patients with adenocarcinoma of the lung who had alterations of both Rb and ras p21 or of both Rb and p53 had significantly worse overall prognoses.
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Comparison of a genetic algorithm neural network with logistic regression for predicting outcome after surgery for patients with nonsmall cell lung carcinoma (pages 1338–1342)Miles F. Jefferson, Neil Pendleton, Sam B. Lucas and Michael A. Horan
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1338::AID-CNCR10>3.0.CO;2-0
The authors present a novel method (a genetic algorithm neural network using Bayes' theorem) and novel measure (an estimate of tumor volume) that significantly improve outcome prediction in patients with surgically treated nonsmall cell lung carcinoma.
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Effect of timing of postoperative chemotherapy on survival of dogs with osteosarcoma (pages 1343–1350)John Berg, Mark C. Gebhardt and William M. Rand
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1343::AID-CNCR11>3.0.CO;2-#
A randomized clinical trial was performed to assess the value of early postoperative initiation of chemotherapy for micrometastases of canine osteosarcoma. There was no significant difference in survival between dogs receiving early postoperative chemotherapy (chemotherapy initiated 2 days after surgery) and dogs receiving conventionally timed chemotherapy (chemotherapy initiated 10 days after surgery).
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Long term follow-up of patients with acute myelogenous leukemia who received the daunorubicin, vincristine, and cytosine arabinoside regimen (pages 1351–1354)Yves Beguin, Brieuc Sautois, Patricia Forget, Jean Bury and Georges Fillet
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1351::AID-CNCR12>3.0.CO;2-Z
Very long term follow-up of a clinical trial of chemotherapy for acute myelogenous leukemia disclosed late relapses and deaths of unrelated causes that significantly contradicted the results of an earlier analysis.
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Patterns of mammographically detected calcifications after breast-conserving therapy associated with tumor recurrence (pages 1355–1361)D. David Dershaw, Catherine S. Giess, Beryl McCormick, Patrick Borgen, Laura Liberman, Andrea F. Abramson and Elizabeth Morris
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1355::AID-CNCR13>3.0.CO;2-Z
When calcifications are observed mammographically in a recurrence of breast carcinoma after breast conservation therapy, their pattern is usually highly malignant. Less worrisome calcifications are unusual, and women should not undergo biopsy for new, benign types because these do not herald local treatment failure.
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Breast-conserving therapy for Stage I-II synchronous bilateral breast carcinoma (pages 1362–1369)Smitha V. Gollamudi, Rebecca S. Gelman, Gloria Peiro, Lindsey J. Schneider, Stuart J. Schnitt, Abram Recht, Barbara J. Silver, Jay R. Harris and James L. Connolly
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1362::AID-CNCR14>3.0.CO;2-Y
Early-stage, synchronous bilateral breast carcinoma can be safely and effectively treated with breast-conserving therapy.
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Prognostic factors for clinically localized prostate carcinoma : Analysis of 938 patients irradiated in the prostate specific antigen era (pages 1370–1380)Gunar K. Zagars, Alan Pollack and Andrew C. von Eschenbach
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1370::AID-CNCR15>3.0.CO;2-X
Although pretreatment prostate specific antigen level is one of the most important prognostic factors for clinically localized prostate carcinoma, it has supplemented, rather than supplanted, the utility of T classification and Gleason score.
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Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas (pages 1381–1393)Stephen W. Coons, Peter C. Johnson, Bernd W. Scheithauer, Allan J. Yates and Dennis K. Pearl
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1381::AID-CNCR16>3.0.CO;2-W
Interobserver variation in the pathologic diagnosis of gliomas was determined. Histologic criteria were refined to improve diagnostic accuracy and reproducibility.
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Vinorelbine, cisplatin, and 5-fluorouracil as initial treatment for previously untreated, unresectable squamous cell carcinoma of the head and neck : Results of a Phase II multicenter study (pages 1394–1400)Vittorio Gebbia, Glovanni Mantovani, Antonio Farris, Biagio Agostara, Alberto Desogus, Luigi Curreli, Francesco Moschella, Carlo Di Gregorio, Emilio Bajetta and Nicolò Gebbia
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1394::AID-CNCR17>3.0.CO;2-V
This article describes a Phase II study of a combination of vinorelbine, cisplatin, and 5-fluorouracil in a series of 60 patients with previously untreated squamous cell carcinoma of the head and neck region. The regimen was very active and well tolerated in most cases, and neurotoxicity was not a major side effect.
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Soluble interleukin-2 receptor serum level as a predictor of locoregional control and survival for patients with head and neck carcinoma : Results of a multivariate prospective study (pages 1401–1408)Eric Tartour, Laurent Deneux, Veronique Mosseri, Christian Jaulerry, Françoise Brunin, Daniel Point, Pierre Validire, Bernard Dubray, Wolf Herman Fridman and José Rodriguez
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1401::AID-CNCR18>3.0.CO;2-3
In a multivariate prospective study, soluble interleukin-2 receptor serum level at the time of diagnosis appeared to be a new independent prognostic variable for predicting the risk of locoregional recurrence and survival for patients with head and neck squamous cell carcinoma.
General Topic
Immunology/Immunotherapy
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Interleukin-2 liposome inhalation therapy is safe and effective for dogs with spontaneous pulmonary metastases (pages 1409–1421)Chand Khanna, Peter M. Anderson, Diane E. Hasz, Emmanuel Katsanis, Mary Neville and Jeffrey S. Klausner
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1409::AID-CNCR19>3.0.CO;2-3
Nebulized interleukin-2 liposomes were effective and nontoxic when given to dogs with spontaneous cancers. Two of these dogs had complete regression of pulmonary metastases.
Lymphoma: Nodal or Extranodal
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Late relapse after treatment for clinical Stage I and II Hodgkin's disease (pages 1422–1427)James D. Brierley, Adrian J. Rathmell, Mary K. Gospodarowicz, Simon B. Sutcliffe and Melania Pintillie
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1422::AID-CNCR20>3.0.CO;2-0
The incidence of late relapse in patients with early stage Hodgkin's disease was examined. Their survival after late relapse was better than that after early relapse.
Pain Control in Cancer Patients
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Comparative clinical efficacy and safety of a novel controlled-release oxycodone formulation and controlled-release hydromorphone in the treatment of cancer pain (pages 1428–1437)Neil A. Hagen and Najib Babul
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1428::AID-CNCR21>3.0.CO;2-0
Controlled-release oxycodone demonstrated effectiveness and a side effect profile similar to that of controlled-release hydromorphone in patients with severe cancer pain. This study offers evidence that oxycodone can be used as an alternative to conventional opioids in the treatment of chronic severe cancer pain.
Pediatric Oncology
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Monosomy 7 myelodysplastic syndrome and other second malignant neoplasms in children with neurofibromatosis type 1 (pages 1438–1446)John M. Maris, Susan R. Wiersma, Nidal Mahgoub, Patricia Thompson, Russell J. Geyer, Carole G. H. Hurwitz, Beverly J. Lange and Kevin M. Shannon
Article first published online: 28 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970401)79:7<1438::AID-CNCR22>3.0.CO;2-#
Children with neurofibromatosis type 1 (NF1) who develop cancer, especially those with embryonal malignancies, are at high risk for developing second malignant neoplasms (SMN), including monosomy 7 myelodysplastic syndrome. The role of somatic NF1 gene alterations in the genesis of these SMNs remains unclear.
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