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Cancer

Cover image for Cancer

15 May 1997

Volume 79, Issue 10

Pages 1853–2061

  1. Tribute

    1. Top of page
    2. Tribute
    3. Editorials
    4. Original Articles
    5. Communications
    1. You have free access to this content
      Oscar Auerbach, M.D. : In memoriam (pages 1853–1855)

      Lawrence Garfinkel

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1853::AID-CNCR1>3.0.CO;2-H

  2. Editorials

    1. Top of page
    2. Tribute
    3. Editorials
    4. Original Articles
    5. Communications
    1. Counterpoint

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      Use of primary breast carcinoma characteristics to predict lymph node metastases (pages 1856–1861)

      Blake Cady

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1856::AID-CNCR2>3.0.CO;2-E

      Analysis of primary cancer features has enabled the authors of the referenced article to define a large proportion of patients with T1 (≤2 cm) invasive breast carcinomas that do not require axillary lymph node dissection. If lymph node histology is required for detailed staging or prognostic data, it will be obtainable by use of physiologically defined "sentinel" lymph node biopsy under local anesthesia. The primary thrust of breast carcinoma control today should be the achievement of universal mammographic screening of appropriately aged women, which has the potential of reducing the median maximum dimensions of all invasive breast carcinomas to only 1 cm within a decade, with commensurate marked reduction of lymph node metastases.

      See also pages 1862–1864 and 1918-1922.

    2. Reply to Counterpoint

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      Use of primary breast carcinoma characteristics to predict lymph node metastases—reply (pages 1862–1864)

      Melvin J. Silverstein and Andreas Barth

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1862::AID-CNCR3>3.0.CO;2-I

      See also pages 1856–1861 and 1918–1922.

  3. Original Articles

    1. Top of page
    2. Tribute
    3. Editorials
    4. Original Articles
    5. Communications
    1. Anatomic Site

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      Diffuse pagetoid squamous cell carcinoma in situ of the esophagus : A case report (pages 1865–1870)

      Peiguo Chu, John Stagias, A. Brian West and Morris Traube

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1865::AID-CNCR4>3.0.CO;2-F

      This article describes a circumferential in situ squamous cell carcinoma of the lower esophagus that had extended by pagetoid spread within surface and gland duct epithelium to occupy 45 cm2 of the mucosa. The tumor cell phenotype is suggestive of origin from undifferentiated esophageal epithelial stem cells and is distinct from the phenotypes of Paget's disease of the breast or vulva.

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      Basaloid squamous cell carcinoma of the esophagus : Diagnosis and prognosis (pages 1871–1878)

      Mario Sarbia, Patrick Verreet, Fernando Bittinger, Philipp Dutkowski, Hansjörg Heep, Reinhart Willers and Helmut E. Gabbert

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1871::AID-CNCR5>3.0.CO;2-J

      Basaloid squamous cell carcinoma is a poorly differentiated variant of typical squamous cell carcinoma. However, after potentially curative resection, the prognosis of patients with basaloid squamous cell carcinoma of the esophagus does not differ from that of patients with typical squamous cell carcinoma.

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      Detection of epidermal growth factor receptor in the serum of gastric carcinoma patients (pages 1879–1883)

      Jin-Hyuk Choi, Jee Young Oh, Sung Ki Ryu, Seung Jung Kim, Na Young Lee, Young Sun Kim, Sun Young Yi, Kang Sup Shim and Woon Sup Han

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1879::AID-CNCR6>3.0.CO;2-B

      Epidermal growth factor receptor (EGFR) serum levels as measured by enzyme-linked immunosorbent assay were elevated more than 2 standard deviations above the mean for healthy controls in 77.5% of gastric carcinoma patients. EGFR assays may be a useful tumor marker for gastric carcinoma.

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      Uracil and tegafur modulated with leucovorin : An effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly (pages 1884–1889)

      J. Feliu, M. González Barón, E. Espinosa, C. García Girón, I. de la Gándara, J. Espinosa, A. Colmenarejo, J. I. Jalón, Y. Fernández and J. de Castro

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1884::AID-CNCR7>3.0.CO;2-G

      The outpatient administration of the combination of uracil and tegafur with leucovorin to elderly patients with advanced colorectal carcinoma shows efficacy and low toxicity.

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      A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein (pages 1890–1896)

      Eiji Ando, Fumihiko Yamashita, Masatoshi Tanaka and Kyuichi Tanikawa

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1890::AID-CNCR8>3.0.CO;2-K

      A repeated arterial infusion chemotherapy in which cisplatin (10 mg) and 5-fluorouracil (250 mg) are administered via a subcutaneously implanted injection port may be useful in treating patients with advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein.

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      Combined cisplatin, doxorubicin, and mitomycin for the treatment of advanced pleural mesothelioma : A Phase II FONICAP trial (pages 1897–1902)

      Maria Cristina Pennucci, Andrea Ardizzoni, Paolo Pronzato, Marina Fioretti, Claudio Lanfranco, Anna Verna, Guglielmina Giorgi, Antonella Vigani, Carlo Frola and Riccardo Rosso

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1897::AID-CNCR9>3.0.CO;2-D

      The combination of cisplatin, doxorubicin, and mitomycin is feasible and moderately active in patients with mesothelioma. However, the level of activity is similar to that observed in other two-drug regimens.

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      Myxoid chondrosarcoma (chordoid sarcoma) of bone : A report of two cases and review of the literature (pages 1903–1910)

      Scott E. Kilpatrick, Carrie Y. Inwards, Christopher D. M. Fletcher, Michael A. Smith and Steven Gitelis

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1903::AID-CNCR10>3.0.CO;2-Z

      Skeletal chordoid sarcoma is an extraordinarily rare neoplasm with a distinct morphology. Although follow-up data are limited, the clinical course appears worse than that for usual chondrosarcoma of bone. Wide surgical resection appears to represent the best mode of therapy. The role of chemotherapy and radiation therapy has not been clearly defined.

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      The presence of mucosal human papillomavirus in Bowen's disease of the hands (pages 1911–1917)

      Tsuyoshi Mitsuishi, Tetsutaro Sata, Toshihiko Matsukura, Takuya Iwasaki and Makoto Kawashima

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1911::AID-CNCR11>3.0.CO;2-Y

      Polymerase chain reaction analysis revealed a high frequency of human papillomavirus (HPV) DNA in Bowen's disease of the hands. The HPV genotypes identified were classified as mucosal or genital types.

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      Predictors of axillary lymph node metastases in patients with T1 breast carcinoma (pages 1918–1922)

      Andreas Barth, Pamela H. Craig and Melvin J. Silverstein

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1918::AID-CNCR12>3.0.CO;2-Y

      Clinical and pathologic features of the primary tumor can help to estimate the risk of axillary lymph node metastases in patients with T1 breast carcinoma. Such risk assessment might facilitate appropriate management of the axilla.

      See also pages 1856–1861 and 1862–1864.

    10. You have free access to this content
      Survival of women ages 40-49 years with breast carcinoma according to method of detection (pages 1923–1932)

      Carol P. McPherson, Karen K. Swenson, Gail Jolitz and Charles L. Murray

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1923::AID-CNCR13>3.0.CO;2-X

      Women ages 40-49 years whose invasive breast carcinoma is detected by mammography have significantly smaller tumors, more localized disease, and may have a lower risk of mortality than women whose tumors are detected by other methods.

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      Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation (pages 1933–1943)

      Ruth A. Lininger, Raheela Ashfaq, Jorge Albores-Saavedra and Fattaneh A. Tavassoli

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1933::AID-CNCR14>3.0.CO;2-W

      A small series of transitional cell carcinomas (TCCs) of the endometrium is reported. TCC of the endometrium is a rare entity that shows urothelial differentiation but demonstrates the cytokeratin 7 and 20 immunoprofile of endometrial carcinoma, suggesting that TCCs are all morphologic variants of endometrial carcinoma.

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      Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines (pages 1944–1950)

      Shi-Zhong Bu, De-Ling Yin, Xiu-Hai Ren, Li-Zhen Jiang, Zhi-Jiang Wu, Qi-Rong Gao and Gang Pei

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1944::AID-CNCR15>3.0.CO;2-V

      Progesterone significantly inhibited cell proliferation and induced apoptosis in human 3AO and AO ovarian carcinoma cell lines. Progesterone treatment markedly up-regulates expression of functional p53 in these cells, indicating involvement of p53 in progesterone-induced apoptosis.

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      Prognostic factors in adult granulosa cell tumor of the ovary (pages 1951–1955)

      Brigitte E. Miller, Beth A. Barron, Jim Y. Wan, James E. Delmore, Elvio G. Silva and David M. Gershenson

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1951::AID-CNCR16>3.0.CO;2-U

      Factors associated with poor prognosis in adult granulosa cell tumors of the ovary include advanced tumor stage and size, absence of Call-Exner bodies, cellular atypia, and higher mitotic rate. However, these cannot be used to predict late recurrences reliably.

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      High and low risk prostate carcinoma determined by histologic grade and proliferative activity (pages 1956–1963)

      Luigi Chiusa, Diego Galliano, Andrea Formiconi, Otello Di Primio and Achille Pich

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1956::AID-CNCR17>3.0.CO;2-U

      The combination of histologic grade and cell proliferative activity, as assessed by argyrophilic nucleolar organizer region analysis, allows the stratification of patients with prostate carcinoma into low and high risk groups.

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      Flutamide withdrawal plus hydrocortisone resulted in clinical complete response in a patient with prostate carcinoma (pages 1964–1968)

      William D. Figg, Glenn Kroog, Paul Duray, McClellan M. Walther, Nicholas Patronas, Oliver Sartor and Eddie Reed

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1964::AID-CNCR18>3.0.CO;2-T

      A 71-year-old patient with prostate carcinoma had a clinical complete response to flutamide withdrawal plus hydrocortisone. At last follow-up, the response had been maintained for more than 46 months.

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      Detection of prostate carcinoma using prostate specific antigen, its density, and the density of the transition zone in Japanese men with intermediate serum prostate specific antigen concentrations (pages 1969–1976)

      Kazuo Gohji, Masashi Nomi, Shin Egawa, Koichi Morisue, Atsushi Takenaka, Masayuki Okamoto, Makoto Ohori and Akio Fujii

      Article first published online: 17 JUL 2009 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1969::AID-CNCR19>3.0.CO;2-T

      Although use of prostate specific antigen density (PSAD) and PSAD of the transition zone decrease the number of unnecessary biopsies in Japanese men, a significant number of prostate carcinomas may be overlooked.

    17. You have free access to this content
      Quality of life and treatment outcomes : Prostate carcinoma patients' perspectives after prostatectomy or radiation therapy (pages 1977–1986)

      Cheryl L. Shrader-Bogen, Janice L. Kjellberg, Carol P. McPherson and Charles L. Murray

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1977::AID-CNCR20>3.0.CO;2-R

      One to five years after treatment for clinically localized prostate carcinoma, men who underwent prostatectomy reported more sexual and urinary dysfunction, whereas men who underwent radiotherapy reported more bowel dysfunction. Quality of life, as determined by the Functional Assessment of Cancer Therapy-General form, was similar in the two treatment groups.

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      Allium sativum (garlic) treatment for murine transitional cell carcinoma (pages 1987–1994)

      Dale R. Riggs, Jean I. DeHaven and Donald L. Lamm

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1987::AID-CNCR21>3.0.CO;2-Q

      The demonstration that oral administration of garlic (Allium sativum) can inhibit the growth of immunosensitive but highly aggressive murine bladder carcinoma suggests that this oral therapy might be an effective adjuvant to surgical resection. Allium sativum has definite reproducible antitumor activity, and further investigation of its use in the treatment of transitional cell carcinoma of the bladder is warranted.

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      Central neurocytoma : The role of radiation therapy and long term outcome (pages 1995–2002)

      Dong Gyu Kim, Sun Ha Paek, II Han Kim, Je G. Chi, Hee-Won Jung, Dae Hee Han, Kil Soo Choi and Byung-Kyu Cho

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<1995::AID-CNCR22>3.0.CO;2-P

      It is suggested that even if the biologic behavior of a central neurocytoma is benign, radiation therapy appears to have an effect on tumor control. However, it should be decided carefully whether to use radiation therapy for a residual tumor because radiation can cause delayed complications and the clinical course of patients with subtotally resected tumors who do not undergo radiation therapy has been found to be extremely benign.

    20. You have free access to this content
      Secretory meningioma : Clinical, histologic, and immunohistochemical findings in 31 cases (pages 2003–2015)

      Stefan Probst-Cousin, Rafael Villagran-Lillo, Rainer Lahl, Markus Bergmann, Kurt W. Schmid and Filippo Gullotta

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2003::AID-CNCR23>3.0.CO;2-X

      Unique clinical, histologic, and immunohistochemical features justify the categorization of secretory meningioma as a distinct type of meningioma.

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      A Phase I report of paclitaxel dose escalation combined with a fixed dose of carboplatin in the treatment of head and neck carcinoma (pages 2016–2023)

      Frank R. Dunphy, James H. Boyd, Han J. Kim, Cherie H. Dunphy, Bruce R. Harrison, Teresa L. Dunleavy, Jack J. Rodriguez, Erin M. McDonough, Jeffrey R. Minster and Jack G. Hilton

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2016::AID-CNCR24>3.0.CO;2-W

      In this study, the maximum tolerated dose of paclitaxel was 250 mg/m2 when combined with a fixed dose of carboplatin (area under the curve, 7.5) and growth factor support.

    22. General Topic

      Complications of Therapy: Genetic Predisposition
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      Tamoxifen-associated venous thrombosis and activated protein C resistance due to factor V leiden (pages 2024–2027)

      Ilene C. Weitz, Valerie K. Israel and Howard A. Liebman

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2024::AID-CNCR25>3.0.CO;2-V

      In this report, three patients who developed venous thrombosis while receiving tamoxifen were shown to be carriers of the gene for Factor V Leiden, which is responsible for the prothrombotic disorder known as activated protein C resistance. It is proposed that Factor V Leiden may be a significant predisposing factor for the development of thrombosis in patients who receive tamoxifen.

    23. Neuroblastoma in Adults and Adolescents
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      Neuroblastoma in adults and adolescents : An indolent course with poor survival (pages 2028–2035)

      Loraine M. Franks, Andrew Bollen, Robert C. Seeger, Daniel O. Stram and Katherine K. Matthay

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2028::AID-CNCR26>3.0.CO;2-V

      A retrospective review of 16 adult and adolescent patients with neuroblastoma treated at UCSF since 1968, compared with survival data from the Children's Cancer Group, is presented. The findings indicate that neuroblastoma in adolescents and adults has different biologic characteristics and a longer course than observed in children, with a poor outcome regardless of stage.

    24. Pediatric Oncology
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      A neuroblastoma cell line derived from a case detected through a mass screening system in Japan : A case report including the biologic and phenotypic characteristics of the cell line (pages 2036–2044)

      Hisayuki Hiraiwa, Minoru Hamazaki, Ayako Takata, Haruto Kikuchi and Jun-ichi Hata

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2036::AID-CNCR27>3.0.CO;2-U

      A neuroblastoma cell line established from a case detected through a mass screening system has a nature distinct from the original tumor tissue that had favorable histopathology and biology. It will be a useful model for investigating the properties of the neuroblastoma in relation to the N-myc amplification mechanism.

    25. You have free access to this content
      The age peak in childhood acute lymphoblastic leukemia : Exploring the potential relationship with socioeconomic status (pages 2045–2051)

      Andrine R. Swensen, Julie A. Ross, Richard K. Severson, Brad H. Pollock and Leslie L. Robison

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2045::AID-CNCR28>3.0.CO;2-T

      In an ecologic analysis, no statistically significant differences were found between socioeconomic status indicators for either white or African American children diagnosed with acute lymphoblastic leukemia during the peak ages of 2-5 years versus those diagnosed at other ages.

  4. Communications

    1. Top of page
    2. Tribute
    3. Editorials
    4. Original Articles
    5. Communications
    1. The American College of Surgeons Commission on Cancer and the American Cancer Society

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      A comparison of breast, colorectal, lung, and prostate cancers reported to the National Cancer Data Base and the Surveillance, Epidemiology, and End Results program (pages 2052–2061)

      Curtis J. Mettlin, Herman R. Menck, David P. Winchester and Gerald P. Murphy

      Article first published online: 29 SEP 2000 | DOI: 10.1002/(SICI)1097-0142(19970515)79:10<2052::AID-CNCR29>3.0.CO;2-S

      Data on breast, colorectal, lung, and prostate cancer reported to the Surveillance, Epidemiology, and End Results program and the National Cancer Data Base in 1992 were found to be similar with respect to patient, disease, and treatment characteristics.

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