Expression of the MDR1 gene product P-glycoprotein in childhood neuroblastoma (pages 1250–1257)
Catharina R. M. Dhooge, Barbara M. J. De Moerloose, Yves C. M. Benoit, Nadine Van Roy, Jan Philippé and Geneviève G. M. Laureys
Version of Record online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971001)80:7<1250::AID-CNCR8>3.0.CO;2-O
The prognostic relevance of P-glycoprotein expression in childhood neuroblastoma was not clear from the results of this study. However, the finding that metastatic cells are capable of expressing MDR1, in contrast to the neuroblastoma cells of the primary tumor, would certainly be an interesting topic for further study as work directed at understanding the progression to metastasis continues.