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Cancer

Cover image for Cancer

15 October 1997

Volume 80, Issue 8

Pages 1363–1526

  1. Editorials

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Original Articles
    5. Communications
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      Prognostic factor development : An important caution from a small study (pages 1363–1365)

      L. Peter Fielding

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1363::AID-CNCR1>3.0.CO;2-G

      Lymph nodes that are shown to be negative for tumor by hematoxylin and eosin staining may appear positive for tumor on polymerase chain reaction (PCR). Consequently, PCR positivity alone must not be used as evidence of lymph node metastasis. The "clinical" meaning of PCR positivity in lymph node tissue requires detailed study before it can or should be used as a prognostic marker.

      See also pages 1393-8.

  2. Review Articles

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Original Articles
    5. Communications
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      Primary small cell carcinoma of the esophagus : A review of the literature with emphasis on therapy and prognosis (pages 1366–1372)

      Francesc Casas, Ferran Ferrer, Blanca Farrús, Joan Casals and Albert Biete

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1366::AID-CNCR2>3.0.CO;2-D

      Data on 199 patients diagnosed with esophageal small cell carcinoma (SCC), selected from among a total of 230 found in the literature, were evaluated in an attempt to study the best management strategy. The authors suggest that, to increase survival, both chemotherapy and radiotherapy be used as standard treatment of limited stage SCC of the esophagus.

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      Malignant mucosal melanoma of the head and neck : Review of the literature and report of 14 patients (pages 1373–1386)

      Spiros Manolidis and Paul J. Donald

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1373::AID-CNCR3>3.0.CO;2-G

      Patients with primary malignant mucosal melanoma of the head and neck have a 5-year survival rate of 17%. Approximately 50% of patients experience local failure after surgery, which is the treatment of choice. In this article, 14 patients with this disease are reported, and the literature is comprehensively reviewed.

  3. Original Articles

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Original Articles
    5. Communications
    1. Anatomic Site

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      Is chemoradiation feasible in elderly patients? : A study of 17 patients with anorectal carcinoma (pages 1387–1392)

      Vincenzo Valentini, Alessio G. Morganti, Stefano Luzi, Giovanna Mantello, Giovanna Mantini, Giovanna Salvi and Numa Cellini

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1387::AID-CNCR4>3.0.CO;2-C

      The aim of this study was to determine the tolerance of concomitant chemoradiation in 17 patients age ≥ 75 years, with anorectal carcinoma. The data suggest that concomitant chemoradiation using a schedule of continuous infusion 5-fluorouracil plus bolus mitomycin C and external radiation therapy can be performed safely in selected elderly patients.

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      Predictive value of genetic diagnosis for cancer micrometastasis : Histologic and experimental appraisal (pages 1393–1398)

      Noriko Yamamoto, Yo Kato, Akio Yanagisawa, Hirotoshi Ohta, Takashi Takahashi and Tomoyuki Kitagawa

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1393::AID-CNCR5>3.0.CO;2-G

      This study suggests that positive results with genetic diagnosis may simply indicate the presence of tumor DNA and do not necessarily mean that a true metastasis of viable cancer cells is present. Although the genetic approach may still hold promise for the detection of cancer micrometastases, its predictive value should be carefully assessed clinicopathologically, because its supersensitivity may be associated with a greatly increased false-positive rate.

      See also pages 1363-5.

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      The impact of surgical adjuvant thoracic radiation therapy for patients with nonsmall cell lung carcinoma with ipsilateral mediastinal lymph node involvement (pages 1399–1408)

      Timothy E. Sawyer, James A. Bonner, Perry M. Gould, Robert L. Foote, Claude Deschamps, Victor F. Trastek, Peter C. Pairolero, Mark S. Allen, Edward G. Shaw, Randolph S. Marks, Stephen Frytak, Carla M. Lange and Hongzhe Li

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1399::AID-CNCR6>3.0.CO;2-A

      Adjuvant postoperative thoracic radiotherapy may improve local control and survival in patients with N2 nonsmall cell lung carcinoma.

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      T-cell lymphocytosis associated with lymphocyte-rich thymoma (pages 1409–1417)

      Alice D. Barton

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1409::AID-CNCR7>3.0.CO;2-9

      In rare instances, locally aggressive, lymphocyte-rich thymomas are associated with T-cell lymphocytosis in the peripheral blood. In this article, the pathophysiology of this phenomenon is discussed, using immunophenotyping and gene rearrangement analysis of T cells in both thymoma and peripheral blood.

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      Outcomes of patients with local recurrence of cutaneous malignant melanoma : A population-based study (pages 1418–1425)

      Gabriella Cohn-Cedermark, Eva Månsson-Brahme, Lars Erik Rutqvist, Olle Larsson, Toom Singnomklao and Ulrik Ringborg

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1418::AID-CNCR8>3.0.CO;2-A

      In a population-based study, isolated local recurrence of cutaneous malignant melanoma was found to be rare (1.3%). The outcomes of patients with a local recurrence was relatively favorable, with a melanoma specific survival rate of 83% 5 years after the diagnosis of the recurrence.

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      Predicting ten-year survival of patients with primary cutaneous melanoma : Corroboration of a prognostic model (pages 1426–1431)

      Sedef Sahin, Babar Rao, Alfred W. Kopf, Eric Lee, Darrell S. Rigel, Robert Nossa, Irfan J. Rahman, Hal Wortzel, Ashfaq A. Marghoob and Robert S. Bart

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1426::AID-CNCR9>3.0.CO;2-C

      The results of this study support the University of Pennsylvania four-variable model (age, gender, site, and thickness) for the prognosis of primary cutaneous melanoma, using a New York University Melanoma Cooperative Group data base of 780 patients.

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      Breast carcinoma stage in relation to time interval since last mammography : A registry-based study (pages 1432–1437)

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1432::AID-CNCR10>3.0.CO;2-6

      Breast carcinoma patients diagnosed 5-22 years since their last mammography showed a lower frequency of advanced disease compared with patients who had never been screened. This finding suggests that even if health-aware women who volunteered for screening stop undergoing regular mammography, they present for a relatively prompt diagnosis in the event they develop clinical breast carcinoma.

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      Use of calcium channel blockers and breast carcinoma risk in postmenopausal women (pages 1438–1447)

      Annette L. Fitzpatrick, Janet R. Daling, Curt D. Furberg, Richard A. Kronmal and Joel L. Weissfeld

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1438::AID-CNCR11>3.0.CO;2-6

      A greater than 2-fold increase in the risk of incident invasive breast carcinoma was found to be associated with use of calcium channel blockers in a prospective observational cohort of 3198 women age ≥ 65 years who were assessed annually for medications and followed for 5 years.

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      α-1 acid glycoprotein is an immunosuppressive factor found in ascites from ovarian carcinoma (pages 1448–1456)

      Steven A. Elg, Allan R. Mayer, Linda F. Carson, Leo B. Twiggs, Robert B. Hill and Sundaram Ramakrishnan

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1448::AID-CNCR12>3.0.CO;2-5

      α-1 acid glycoprotein is an immunosuppressive factor in ascites from ovarian carcinoma and appears to inhibit interleukin-2 secretion by lymphocytes.

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      Production of extracellular matrix-degrading proteinases by primary cultures of human epithelial ovarian carcinoma cells (pages 1457–1463)

      David A. Fishman, Lisa M. Bafetti, Saulis Banionis, Alicia S. Kearns, Krishna Chilukuri and M. Sharon Stack

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1457::AID-CNCR13>3.0.CO;2-4

      Production of extracellular matrix-degrading proteinases by short term primary cultures of epithelial ovarian carcinoma cells was analyzed. The cells were derived from primary ovarian tumors, intraperitoneal metastases, and ascites. Matrix metalloproteinase-2 (MMP-2, gelatinase A) was the predominant proteinase secreted, with lower levels of MMP-9 (gelatinase B) and urinary-type plasminogen activator (u-PA) detected. This suggested that MMP-2 may play a significant role in the intraperitoneal invasion of epithelial ovarian carcinoma.

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      Combined treatment of invasive bladder carcinoma with transurethral resection, induction chemotherapy, and radical radiotherapy plus concomitant protracted infusion of cisplatin and 5-fluorouracil : A Phase I Study (pages 1464–1471)

      Donatella Tirindelli Danesi, Giorgio Arcangeli, Enrico Cruciani, Antonella Mecozzi, Bianca Saracino, Stefano Giacobini, Ermanno Pannunzio, Antonio Biggio and Filina Orefici

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1464::AID-CNCR14>3.0.CO;2-3

      This Phase I study, involving patients with infiltrating transitional cell bladder carcinoma, defines the maximum tolerated doses for an innovative schedule of concurrent protracted intravenous infusion of cisplatin and 5-fluorouracil plus hyperfractionated radiotherapy administered with organ-sparing intent. The data suggest that this treatment schedule has the potential to enhance synergistically the effect of radiation and provide higher response rates with very low acute and late toxicity.

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      The prognostic value of p53 nuclear overexpression and MIB-1 as a proliferative marker in transitional cell carcinoma of the bladder (pages 1472–1481)

      Zivko Popov, Andras Hoznek, Marc Colombel, Sylvie Bastuji-Garin, Marie-Aude Lefrere-Belda, Jacqueline Bellot, Claude C. Abbou, Catherine Mazerolles and Dominique K. Chopin

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1472::AID-CNCR15>3.0.CO;2-2

      Quantitative immunohistochemical evaluation of nuclear p53 and MIB-1 immunostaining identifies prognostic indicators inexpensively in cases of TCC of the bladder.

    13. General Topic

      Cancer Comorbidity
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      Socioeconomic status and comorbidity among newly diagnosed cancer patients (pages 1482–1488)

      Carola T. M. Schrijvers, Jan Willem W. Coebergh and Johan P. Mackenbach

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1482::AID-CNCR16>3.0.CO;2-1

      The prevalence of serious comorbidity at the time of diagnosis was higher among breast and lung carcinoma patients with a low socioeconomic status than among those with a high socioeconomic status. Socioeconomic inequalities in cancer survival may be explained partly by such differences in comorbidity.

    14. Immunogenetics of Cancer
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      Polymorphism in the tumor necrosis factor-α promotor region and in the heat shock protein 70 genes associated with malignant tumors (pages 1489–1496)

      Lotfi Chouchane, Slim Ben Ahmed, Sami Baccouche and Sami Remadi

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1489::AID-CNCR17>3.0.CO;2-1

      In malignant tumors in Tunisian patients, a strong association was found between the polymorphisms in tumor necrosis factor-α and in heat shock protein 70 genes. These polymorphisms could have functional consequences for immunologic mechanisms affecting tumor cells and cancer pathogenesis.

    15. Lymphoma, Extranodal
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      Primary cardiac lymphoma in immunocompetent patients : Diagnostic and therapeutic management (pages 1497–1506)

      Giovanni L. Ceresoli, Andrés J. M. Ferreri, Eraldo Bucci, Cristina Ripa, Maurilio Ponzoni and Eugenio Villa

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1497::AID-CNCR18>3.0.CO;2-0

      Early diagnosis and prompt systemic treatment can improve the prognosis of patients with primary cardiac lymphoma (PCL). Two cases of PCL and a review of the literature focusing on diagnostic and therapeutic management are presented.

    16. Pediatric Oncology
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      Thallium-201 scintigraphy for the evaluation of tumor response to preoperative chemotherapy in patients with osteosarcoma (pages 1507–1512)

      Massimo Imbriaco, Samuel D. J. Yeh, Henry Yeung, JiaJu Zhang, John H. Healey, Paul Meyers, Andrew G. Huvos and Steven M. Larson

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1507::AID-CNCR19>3.0.CO;2-9

      Thallium-201 scintigraphy is a simple, reliable technique for assessing response to chemotherapy in patients with osteosarcoma of the extremities.

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      Chest wall rhabdomyosarcoma (pages 1513–1517)

      Nicholas C. Saenz, Fereshteh Ghavimi, William Gerald, Smitha Gollamudi and Michael P. LaQuaglia

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1513::AID-CNCR20>3.0.CO;2-7

      Patients with chest wall rhabdomyosarcoma who are treated aggressively with multimodality therapy may attain long survival. While complete resection is recommended, survival is possible in patients with microscopically positive surgical margins when intense multiagent chemotherapy and radiation is employed.

    18. Psychosociology
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      The supportive care needs of newly diagnosed cancer patients attending a regional cancer center (pages 1518–1524)

      Timothy J. Whelan, E. Ann Mohide, Andrew R. Willan, Andrew Arnold, Michelle Tew, Scott Sellick, Amiram Gafni and Mark N. Levine

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1518::AID-CNCR21>3.0.CO;2-7

      Patients with newly diagnosed cancer commonly report symptoms related to fatigue, pain, and psychologic distress as well as the need for information and social concerns relating to their ability to take care of their home and maintain family and other relationships. Awareness of these issues is important for planning supportive care services for newly diagnosed cancer patients.

  4. Communications

    1. Top of page
    2. Editorials
    3. Review Articles
    4. Original Articles
    5. Communications
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      Politics and addiction : An update on the tobacco settlement (pages 1525–1526)

      John R. Seffrin

      Article first published online: 20 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1525::AID-CNCR22>3.0.CO;2-6

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