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Original Article
Predicting ten-year survival of patients with primary cutaneous melanoma
Corroboration of a prognostic model
Article first published online: 20 NOV 2000
DOI: 10.1002/(SICI)1097-0142(19971015)80:8<1426::AID-CNCR9>3.0.CO;2-C
Copyright © 1997 American Cancer Society
1097-0142/asset/cover.gif?v=1&s=a7299bc18f075294c232ade468773cd0672bd470 "Cancer")
Additional Information
How to Cite
Sahin, S., Rao, B., Kopf, A. W., Lee, E., Rigel, D. S., Nossa, R., Rahman, I. J., Wortzel, H., Marghoob, A. A. and Bart, R. S. (1997), Predicting ten-year survival of patients with primary cutaneous melanoma. Cancer, 80: 1426–1431. doi: 10.1002/(SICI)1097-0142(19971015)80:8<1426::AID-CNCR9>3.0.CO;2-C
Publication History
- Issue published online: 20 NOV 2000
- Article first published online: 20 NOV 2000
- Manuscript Accepted: 16 MAY 1997
- Manuscript Received: 7 MAR 1997
Funded by
- Joseph H. Hazen Foundation
- Ronald O. Perelman Department of Dermatology
- New York University School of Medicine
- Niarchos Fund of the Skin Cancer Foundation
- Kaplan Comprehensive Cancer Center. Grant Number: 5P30 CA-16087
- Mary and Emanuel Rosenfeld Foundation
- National Institutes of Health/National Cancer Institute. Grant Number: 2R44CA/AR60229-02
- Abstract
- Article
- References
- Cited By
Keywords:
- primary cutaneous melanoma;
- prognosis;
- multivariate analysis;
- survival
The results of this study support the University of Pennsylvania four-variable model (age, gender, site, and thickness) for the prognosis of primary cutaneous melanoma, using a New York University Melanoma Cooperative Group data base of 780 patients.
Abstract
BACKGROUND
Recently, the Pigmented Lesion Group at the University of Pennsylvania described a 4-variable model for predicting 10-year survival for patients with primary cutaneous melanoma. The variables are tumor thickness, anatomic site of the lesion, age, and gender. The objective of the current study was to test the validity of this model, employing the large data base of the New York University Melanoma Cooperative Group.
METHODS
The predicted probabilities of 10-year survival for 780 patients with primary cutaneous melanoma were determined by multivariate logistic regression, using the 4 variables.
RESULTS
The overall 10-year survival rate of the current study group was 78.4%. Of the four variables, tumor thickness, anatomic site of the lesion, and age were found to be independent predictors of survival. Although survival was better for women, gender was not a statistically significant factor in predicting 10-year survival when entered into the multivariate logistic regression model. In the current study, the probability of 10-year survival of patients with melanomas < 0.76 mm ranged from 93-99%, depending on the age and primary site. Age and site had more impact on the prognosis of intermediate and thick melanomas than on thin melanomas. Thus, for melanomas 0.76-1.69 mm, 1.70-3.60 mm, and thicker than 3.60 mm, the probabilities of survival ranged from 70-94%, 39-82%, and 23-68%, respectively.
CONCLUSIONS
The wider ranges in survival rates for thicker melanomas, depending on the other variables, emphasize the importance of including variables in addition to tumor thickness in a prognostic model. Using a large data base from a medical center, the current study supports the prognostic multivariate model of the Pigmented Lesions Group of the University of Pennsylvania; however, the authors of the current study did not find gender to be statistically significant in this multivariate model. Cancer 1997; 80:1426-31. © 1997 American Cancer Society.