Presented at the Skeletal Complications of Malignancy Symposium, Bethesda, Maryland, April 19-20, 1997.
General mechanisms of metastasis†
Article first published online: 20 NOV 2000
Copyright © 1997 American Cancer Society
Supplement: Proceedings of the Symposium “Skeletal Complications of Malignancy” presented by The Paget Foundation For Paget's Disease of Bone and Related Disorders
Volume 80, Issue Supplement 8, pages 1529–1537, 15 October 1997
How to Cite
Woodhouse, E. C., Chuaqui, R. F. and Liotta, L. A. (1997), General mechanisms of metastasis. Cancer, 80: 1529–1537. doi: 10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID-CNCR2>3.0.CO;2-F
- Issue published online: 20 NOV 2000
- Article first published online: 20 NOV 2000
- growth factor
In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed. Cancer 1997; 80:1529-37. © 1997 American Cancer Society.