Adult Wilms' tumor

A case report

Authors

  • Michele Orditura M.D.,

    1. Department of Internal and Experimental Medicine "F. Magrassi", Division of Medical Oncology, II University of Naples School of Medicine, Naples, Italy
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  • Ferdinando De Vita M.D., Ph.D.,

    1. Department of Internal and Experimental Medicine "F. Magrassi", Division of Medical Oncology, II University of Naples School of Medicine, Naples, Italy
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  • Giuseppe Catalano M.D.

    Corresponding author
    1. Department of Internal and Experimental Medicine "F. Magrassi", Division of Medical Oncology, II University of Naples School of Medicine, Naples, Italy
    • Department of Internal & Experimental Medicine "F. Magrassi," Division of Medical Oncology, II University of Naples Medical School, II Policlinico, Via S. Pansini 5, 80131, Naples, Italy
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Abstract

BACKGROUND

Wilms' tumor in an adult is rare and no treatment guidelines have been established, although all authors recommend aggressive therapy based on surgery, radiotherapy, and multiagent chemotherapy.

METHODS

The authors describe a case of Wilms' tumor in a 23-year-old woman who developed hepatic and pulmonary metastases after undergoing nephrectomy. Treatment was initiated with carboplatin, etoposide, ifosfamide, and epirubicin combination chemotherapy and irradiation of the tumor bed, lungs, and liver.

RESULTS

Metastatic workup was negative 41 months after suspension of chemoradiotherapy. Hematologic toxicity was high, but was manageable with adequate supportive care.

CONCLUSIONS

Because this multimodal treatment, which included a chemotherapeutic regimen with single agents generally used in patients with recurrent disease, had impressive activity in this patient with an advanced adult Wilms' tumor, the issue of further investigation of this alternative schedule is raised. Cancer 1997; 80:1961-5. © 1997 American Cancer Society.

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