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Primary non-hodgkin's lymphoma of the lacrimal sac

A case report and a review of the literature

  1. Katsumasa Nakamura M.D.1,*,
  2. Satoru Uehara M.D.2,
  3. Junichi Omagari M.D.1,
  4. Naonobu Kunitake M.D.1,
  5. Masahiko Kimura M.D.1,
  6. Yasuhiro Makino M.D.1,
  7. Kousei Ishigami M.D.1,
  8. Kouji Masuda M.D.1

Article first published online: 20 NOV 2000

DOI: 10.1002/(SICI)1097-0142(19971201)80:11<2151::AID-CNCR15>3.0.CO;2-Y

Issue

Cancer

Cancer

Volume 80, Issue 11, pages 2151–2155, 1 December 1997

Additional Information

How to Cite

Nakamura, K., Uehara, S., Omagari, J., Kunitake, N., Kimura, M., Makino, Y., Ishigami, K. and Masuda, K. (1997), Primary non-hodgkin's lymphoma of the lacrimal sac. Cancer, 80: 2151–2155. doi: 10.1002/(SICI)1097-0142(19971201)80:11<2151::AID-CNCR15>3.0.CO;2-Y

Author Information

  1. 1

    Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

  2. 2

    School of Health Sciences, Kyushu University, Fukuoka, Japan

*Department of Radiology, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812, Japan

Publication History

  1. Issue published online: 20 NOV 2000
  2. Article first published online: 20 NOV 2000
  3. Manuscript Revised: 4 JUN 1997
  4. Manuscript Accepted: 4 JUN 1997
  5. Manuscript Received: 26 FEB 1997

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Keywords:

  • non-Hodgkin's lymphoma;
  • lacrimal sac;
  • B-cell lymphoma;
  • radiotherapy

Primary non-Hodgkin's lymphoma of the lacrimal sac is usually of B-cell origin and responds well to radiotherapy and/or chemotherapy.

Abstract

BACKGROUND

Primary non-Hodgkin's lymphoma of the lacrimal sac is extremely rare, with most reported cases representing secondary involvement of a systemic malignancy.

METHODS

The clinical record of a 70-year-old female who presented with epiphora and swelling of the lacrimal sac area is described. A review of the literature of patients with primary lacrimal sac lymphoma also is presented.

RESULTS

Computed tomography demonstrated a lacrimal sac mass involving the nasolacrimal canal. Histopathologic examination of a biopsy specimen revealed a diffuse large cell lymphoma. Using immunohistologic staining, the tumor was a B-cell type, similar to those described in the literature. The patient was treated with 50 gray of irradiation and chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone. The patient remained free of lymphoma 26 months after initial treatment. An ocular examination was unremarkable except for epiphora.

CONCLUSIONS

Radiotherapy and/or chemotherapy can treat localized lymphoma of the lacrimal sac successfully. Cancer 1997; 80:2151-5. © 1997 American Cancer Society.

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