Anatomic Site
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Induction chemotherapy is Associated with an increase in the incidence of locoregional recurrence in patients with carcinoma of the oral cavity : Results from a single institution (pages 804–815)Masaya Okura, Tsutomu Hiranuma, Tadafumi Adachi, Takafumi Ogura, Tomonao Aikawa, Hideo Yoshioka, Yasutaka Hayashido, Mikihiko Kogo and Tokuzo Matsuya
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<804::AID-CNCR2>3.0.CO;2-J
In a retrospective analysis of 141 patients with squamous cell carcinoma of the oral cavity, induction chemotherapy is believed to be associated with a significant increase in failure to control disease in the neck. In subset analysis, induction chemotherapy had a significant disadvantage for disease free survival of patients with carcinoma of the oral cavity with N0 disease as well as those with Stage II disease.
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Overexpression of elongation factor-1γ protein in colorectal carcinoma (pages 816–821)Sandip Mathur, Karen R. Cleary, Nikhil Inamdar, Yeul Hong Kim, Peter Steck and Marsha L. Frazier
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<816::AID-CNCR3>3.0.CO;2-H
The study demonstrated the elongation factor (EF)-1γ was overexpressed at the protein level in 17 of 29 colorectal carcinomas relative to normal-appearing more distal mucosa. In addition, EF-1γ immunoreactivity was located predominantly in the epithelial cells of the tumor.
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Primary sclerosing cholangitis and colorectal carcinoma in patients with chronic ulcerative colitis : A case-control study (pages 822–826)Kofi W. Nuako, David A. Ahlquist, William J. Sandborn, Douglas W. Mahoney, Diane M. Siems and Alan R. Zinsmeister
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<822::AID-CNCR4>3.0.CO;2-L
Among 171 ulcerative colitis cases with colorectal carcinoma and 171 controls with ulcerative colitis without neoplasia, the prevalence of primary sclerosing cholangitis was similar, and an association between it and colorectal carcinoma in patients with ulcerative colitis could not be substantiated.
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Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis B virus : A pilot study (pages 827–835)Kenji Ikeda, Satoshi Saitoh, Yoshiyuki Suzuki, Masahiro Kobayashi, Akihito Tsubota, Mizuho Fukuda, Isao Koida, Yasuji Arase, Kazuaki Chayama, Naoya Murashima and Hiromitsu Kumada
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<827::AID-CNCR5>3.0.CO;2-G
Long term therapy with interferon significantly decreased the rate of hepatocellular carcinogenesis in patients with hepatitis B virus (HBV)-related cirrhosis. Patients with a higher HBV DNA concentration were the best candidates for interferon therapy from the viewpoint of an efficient anticarcinogenic project.
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Carboplatin, etoposide, and accelerated hyperfractionated radiotherapy for elderly patients with limited small cell lung carcinoma : A phase II study (pages 836–841)Branislav Jeremic, Yuta Shibamoto, Ljubisa Acimovic and Slobodan Milisavljevic
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<836::AID-CNCR6>3.0.CO;2-H
Seventy-two elderly patients (ages ≥70 years) with limited small cell lung carcinoma were treated with a short term combination regimen consisting of carboplatin and etoposide with accelerated hyperfractionated radiotherapy. Promising long term results were achieved, with a 5-year local control rate of 79% and a 5-year survival rate of 13%.
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Clinical radiation pneumonitis and radiographic changes after thoracic radiation therapy for lung carcinoma (pages 842–850)Jedidiah M. Monson, Paul Stark, John J. Reilly, David J. Sugarbaker, Gary M. Strauss, Scott J. Swanson, Malcolm M. Decamp, Steven J. Mentzer and Elizabeth H. Baldini
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<842::AID-CNCR7>3.0.CO;2-L
Clinical radiation pneumonitis developed in 20% of lung carcinoma patients treated with radiation therapy. Risk factors included low performance status, comorbid lung disease, smoking history, low pulmonary function tests, and the absence of a surgical resection. Posttreatment radiographic changes were common, progressed with time, and typically were not confined to the radiation therapy treatment field.
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Prognostic factors for patients with sarcomas of the pelvic bones (pages 851–859)Akira Kawai, John H. Healey, Patrick J. Boland, Patrick P. Lin, Andrew G. Huvos and Paul A. Meyers
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<851::AID-CNCR8>3.0.CO;2-M
In the treatment of malignant tumors of the pelvis, an adequate surgical margin is critical to prevent local recurrence and the surgical stage is related to the risk of distant metastasis. Patients who underwent a hemipelvectomy and those with an inadequate surgical margin had greater risk of mortality.
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Papillary serous carcinoma of the peritoneum in a man : A case report (pages 860–866)Ifat A. Shah, Lakshmi Jayram, Osama S. Gani, Irwin S. Fox and Thomas M. Stanley
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<860::AID-CNCR9>3.0.CO;2-N
This case report documents that papillary serous carcinoma of the peritoneum, a tumor that until now was observed exclusively in women, has occurred in a man.
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Mobilization, collection, and characterization of peripheral blood hemopoietic progenitors after chemotherapy with epirubicin, paclitaxel, and granulocyte-colony stimulating factor administered to patients with metastatic breast carcinoma (pages 867–873)Carmelo Bengala, Ilaria Pazzagli, Carmelo Tibaldi, Claudio Favre, Renato Vanacore, Francesco Greco, Alessandro Mazzoni, Maria Cristina Menconi, Pierantonio Macchia and Pier Franco Conte
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<867::AID-CNCR10>3.0.CO;2-Z
Epirubicin plus paclitaxel in combination with granulocyte-colony stimulating factor mobilizes peripheral blood progenitor cells, including more primitive progenitors capable of supporting myeloablative treatment. The data from this study show that harvested peripheral blood progenitor cells contain high levels of cytotoxic effector cells suitable for ex vivo manipulation to augment the antitumor effect.
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Predicting response to adjuvant and radiation therapy in patients with early stage breast carcinoma (pages 874–877)Harry B. Burke, Albert Hoang, J. Dirk Iglehart and Jeffrey R. Marks
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<874::AID-CNCR11>3.0.CO;2-Y
Screening and surveillance are increasing the detection of early stage breast carcinoma. However, the TNM staging system does not predict which early stage breast carcinoma patients will respond to postsurgical therapy. An artificial neural network containing p53 and c-erbB-2 accurately predicts response to adjuvant therapy (chemotherapy or tamoxifen therapy) and radiation therapy and thus identifies the best postsurgical therapy for a woman with early stage breast carcinoma.
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Cyclophosphamide, methotrexate, and chronic oral tegafur modulated by folinic acid in the treatment of patients with advanced breast carcinoma (pages 878–885)Antoni Ribas, Joan Albanell, Luis-Alfonso Solé-Calvo, Enrique Gallardo, Joaquim Bellmunt, Ruth Vera, Rosó Vidal, Joan Carulla and José Baselga
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<878::AID-CNCR12>3.0.CO;2-Y
A modified regimen of cyclophosphamide, methotrexate, and 5-fluorouracil in which bolus 5-fluorouracil is substituted with oral tegafur and folinic acid has significant activity both as first-line chemotherapy as well as in other patients with advanced breast carcinoma who had prior chemotherapy.
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The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis : Association with 72-kilodalton metalloproteinase immunostaining (pages 886–892)Gioele G. Garzetti, Andrea Ciavattini, Guendalina Lucarini, Gaia Goteri, Stefano Menso, Michele De Nictolis, Carlo Romanini and Graziella Biagini
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<886::AID-CNCR13>3.0.CO;2-X
Human papillomavirus positive carcinomas showed an increased risk of lymph node metastasis and significantly higher 72-kilodalton metalloproteinase immunostaining.
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Toward the development of a universal grading system for ovarian epithelial carcinoma : Testing of a proposed system in a series of 461 patients with uniform treatment and follow-up (pages 893–901)Yoshio Shimizu, Seiryu Kamoi, Satoshi Amada, Futoshi Akiyama and Steven G. Silverberg
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<893::AID-CNCR14>3.0.CO;2-W
A new grading system applicable to all histologic types of ovarian carcinoma has been developed. It was found to correlate well with clinical outcome in a series of 461 patients with carcinomas of different types and stages.
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Pathologic classification of prostate carcinoma : The impact of margin status (pages 902–908)Michael L. Blute, David G. Bostwick, Thomas M. Seay, Sandra K. Martin, Jeff M. Slezak, Erik J. Bergstralh and Horst Zincke
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<902::AID-CNCR15>3.0.CO;2-4
A proposed modification of the AJCC/UICC pathologic (pTNM) classification system for prostate carcinoma was analyzed for its impact on survival outcome in the prostate specific antigen era. This analysis supports the adoption of the proposed pTNM system, which will allow for uniform reporting of pathologic data on prostate carcinoma.
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Inhibition of the growth of caki-I human renal adenocarcinoma in Vivo by luteinizing hormone-releasing hormone antagonist cetrorelix, somatostatin analog RC-160, and bombesin antagonist RC-3940-II (pages 909–917)Andreas Jungwirth, Andrew V. Schally, Gabor Halmos, Kate Groot, Karoly Szepeshazi, Jacek Pinski and Patricia Armatis
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<909::AID-CNCR16>3.0.CO;2-4
Luteinizing hormone-releasing hormone antagonist Cetrorelix, somatostatin analog RC-160, and bombesin antagonist RC-3940-II effectively inhibit the growth of human Caki-I renal adenocarcinoma in nude mice. These peptide analogs should be considered for the therapy of patients with metastatic or recurrent renal cell carcinoma.
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Rapidly alternating chemotherapy and radiotherapy instead of cystectomy for the treatment of muscle-invasive carcinoma of the urinary bladder : Long term results of a pilot study (pages 918–922)Bhadrasain Vikram, Manjeet Chadha, Stephen C. Malamud, Hubert Hecht and Harry Grabstald
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<918::AID-CNCR17>3.0.CO;2-3
Transurethral resection plus rapidly alternating chemotherapy and radiotherapy controlled muscle-invasive bladder carcinoma with excellent bladder function; thus, it may be a safe and effective alternative to cystectomy for the treatment of patients with locally advanced bladder carcinoma.
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Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis (pages 923–930)Marc H. Friedberg, Michael J. Glantz, Mark S. Klempner, Bernard F. Cole and George Perides
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<923::AID-CNCR18>3.0.CO;2-2
The precursor and activated forms of gelatinases A and B can be detected in the cerebrospinal fluid (CSF) of patients with primary and metastatic brain tumors. The distribution of gelatinase activity in CSF distinguishes patients with intracranial tumors from those without brain tumors.
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Cost minimization analysis and utility of pretreatment and posttreatment total body iodine-131 scans in patients with thyroid carcinoma (pages 931–935)Perry Grigsby
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<931::AID-CNCR19>3.0.CO;2-1
Posttreatment total body iodine-131 (I-131) scans yielded additional information in only 10% of the study patient population treated with postoperative I-131 for thyroid carcinoma. Therefore, the cost, and the associated inconvenience to the patient, of performing a posttreatment total body I-131 scan can be eliminated for most patients.
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Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions (pages 936–943)Michael B. Oude Ophuis, Esther M. M. van Lieshout, Hennie M. J. Roelofs, Wilbert H. M. Peters and Johannes J. Manni
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<936::AID-CNCR20>3.0.CO;2-0
Different genotypes of glutathione S-transferase M1 and T1 and cytochrome P4501A1 are not considered risk factors for head and neck malignancies.
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The clinical importance of cystic squamous cell carcinomas in the neck : A study of 136 cases (pages 944–956)Lester D. R. Thompson and Dennis K. Heffner
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<944::AID-CNCR21>3.0.CO;2-#
Predominantly cystic squamous cell carcinomas in the neck are metastatic (not branchiogenic) and usually originate in occult carcinomas of the tonsils. These tonsillar carcinomas are less aggressive than most mucosal squamous cell carcinomas, and this finding should influence therapeutic choices.
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Long term follow-up and late complications of 2-chlorodeoxyadenosine in previously treated, advanced, indolent non-hodgkin's lymphoma (pages 957–964)Lynn R. Kong, Cheng-Fang Huang, David Hakimian, Daina Variakojis, Leonard Klein, Timothy M. Kuzel, Leo I. Gordon, Connie Zanzig, Eric Wollins and Martin S. Tallman
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<957::AID-CNCR22>3.0.CO;2-Z
2-Chlorodeoxyadenosine, an active agent in the treatment of relapsed non-Hodgkin's lymphoma, may result in delayed bacterial, fungal, or viral infection. The possible relationship to second malignancies requires further investigation.
General Topic
Chemotherapy: Complications
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Hand-foot syndrome following prolonged infusion of high doses of vinorelbine (pages 965–969)Paulo M. Hoff, Vicente Valero, Nuhad Ibrahim, Jie Willey and Gabriel N. Hortobagyi
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<965::AID-CNCR23>3.0.CO;2-Y
Prolonged infusion of high doses of vinorelbine may be associated with hand-foot syndrome. This side effect may be related to schedule as well as dose. Prospective studies are needed to clarify whether premedication with steroids can prevent this occurrence.
Chemotherapy: Toxicity
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Induction of tumor necrosis factor-α as a cause of bleomycin-related toxicity (pages 970–974)Stefan Sleijfer, Zeljko Vujaskovic, Pieter C. Limburg, Heimen Schraffordt Koops and Nanno H. Mulder
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<970::AID-CNCR24>3.0.CO;2-X
There are several indications that the induction of cytokines is related to side effects caused by bleomycin. In this study, induction of tumor necrosis factor-α, but not of interleukin-1β or transforming growth factor-β, was found in patients receiving bleomycin. This finding suggested a role for tumor necrosis factor-α in the development of bleomycin-related toxicity.
Lymphoma, Extranodal
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Risk factors for primary central nervous system lymphoma : A case-control study (pages 975–982)David Schiff, Vera J. Suman, Ping Yang, Walter A. Rocca and Brian P. O'Neill
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<975::AID-CNCR25>3.0.CO;2-X
This is the first case-control study of primary central nervous system lymphoma (PCNSL) in immunocompetent subjects. The authors found significant associations with or suggestive trends in educational status, tonsillectomy, and oral contraceptive use. This study did not find PCNSL to be associated with farming or a prior personal or family history of cancer.
Pediatric Oncology
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T γ/δ hepatosplenic lymphoma in a heart transplant patient after an epstein-barr virus positive lymphoproliferative disorder : A case report (pages 983–992)Madeleine D. Kraus, David F. Crawford, Zahid Kaleem, Shalini Shenoy, Craig A. MacArthur and Janina A. Longtine
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980301)82:5<983::AID-CNCR26>3.0.CO;2-W
In this article, a case of T γ/δ hepatosplenic lymphoma is described and the clinical and pathologic features of 24 previously reported cases of this rare type of lymphoma are presented. The authors also discuss the implications of the immunophenotypic and genetic profile of this entity.
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