Anatomic Site
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Mucoepidermoid carcinoma of the major salivary glands : Clinical and histopathologic analysis of 234 cases with evaluation of grading criteria (pages 1217–1224)Robert K. Goode, Paul L. Auclair and Gary L. Ellis
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1217::AID-CNCR2>3.0.CO;2-C
Histopathologic grading by the criteria described in this article correlates well with the biologic behavior of parotid gland lesions, but it is not useful in predicting the prognoses of patients with mucoepidermoid carcinoma of the submandibular gland.
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The prognostic significance of microvessel density and thymidine phosphorylase expression in squamous cell carcinoma of the esophagus (pages 1225–1232)Masahiko Igarashi, Dipok Kumar Dhar, Hirofumi Kubota, Akitaka Yamamoto, Osama EL-Assal and Naofumi Nagasue
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1225::AID-CNCR3>3.0.CO;2-E
Microvessel density is an independent prognostic factor in squamous cell carcinoma of the esophagus without lymph node metastasis. Thymidine phosphorylase could be one of the angiogenic factors responsible for this tumor.
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Recent advances in surgical treatment have improved the survival of patients with gastric carcinoma (pages 1233–1237)Eigo Otsuji, Toshiharu Yamaguchi, Kiyoshi Sawai, Akeo Hagiwara, Hiroki Taniguchi and Toshio Takahashi
Article first published online: 1 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1233::AID-CNCR4>3.0.CO;2-G
In this study, the survival of 1579 patients who underwent gastrectomy between 1970 and 1994 was retrospectively analyzed. The results indicated that survival has improved with advances in the surgical approach to gastric carcinoma.
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Prognostic value of cyclin E and p53 expression in gastric carcinoma (pages 1238–1243)Teruyuki Sakaguchi, Akihiko Watanabe, Hidetomo Sawada, Yukishige Yamada, Jun Yamashita, Masahiko Matsuda, Masakazu Nakajima, Takeshi Miwa, Tomoko Hirao and Hiroshige Nakano
Article first published online: 1 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1238::AID-CNCR5>3.0.CO;2-B
Cyclin E expression correlates with p53 expression and this combined variable could be a useful prognostic indicator for patients with gastric carcinoma.
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Intraoperative determinants of unresectability for patients with colorectal hepatic metastases (pages 1244–1249)John F. Gibbs, Thomas K. Weber, Miguel A. Rodriguez-Bigas, Deborah L. Driscoll and Nicholas J. Petrelli
Article first published online: 1 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1244::AID-CNCR6>3.0.CO;2-F
A meticulous abdominal exploration prior to hepatic resection for colorectal metastases is essential to identify patients with extrahepatic disease. Periportal and celiac lymph nodes commonly are involved by tumor. Therefore, routine periportal/celiac lymph node biopsies should be performed in the absence of other extrahepatic disease.
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Phase II trial of chemoembolization for the treatment of metastatic colorectal carcinoma to the liver and review of the literature (pages 1250–1259)Claudia Tellez, Al B. Benson III, Michael T. Lyster, Mark Talamonti, John Shaw, Michael A. Braun, Albert A. Nemcek Jr. and Robert L. Vogelzang
Article first published online: 1 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1250::AID-CNCR7>3.0.CO;2-J
Chemoembolization is a feasible treatment modality for patients with colorectal carcinoma metastasis to the liver for whom systemic treatment has failed. The treatment is well tolerated with transient mild-to-moderate toxicity. Responses are generally measured in months. Patients who are able to undergo three or more chemoembolization procedures may receive the most clinical benefit.
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Circulating platelet-derived endothelial cell growth factor increases in hepatocellular carcinoma patients (pages 1260–1267)Kenji Jin-no, Masahito Tanimizu, Ichinosuke Hyodo, Yoshiyuki Nishikawa, Yasushi Hosokawa, Hisashi Endo, Toshihiko Doi, Koichi Mandai and Hideo Ishitsuka
Article first published online: 1 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1260::AID-CNCR8>3.0.CO;2-J
Circulating platelet-derived endothelial cell growth factor (PD-ECGF) levels were highly elevated in patients with hepatocellular carcinoma (HCC), and immunohistologic study showed conspicuous PD-ECGF expression in HCC cells. Circulating PD-ECGF is a possible tumor marker for HCC progression, and may be associated with angiogenesis in HCC.
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Cryosurgery as a treatment for advanced stage hepatocellular carcinoma : Results, complications, and alcohol ablation (pages 1268–1278)Wilson S. Wong, Shirish C. Patel, Federico S. Cruz, Kirit V. Gala and A. Franklin Turner
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1268::AID-CNCR9>3.0.CO;2-B
Cryosurgery is an effective treatment for patients with hepatocellular carcinoma. When cryosurgery is used in combination with alcohol ablation, patient survival can be prolonged.
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Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region (pages 1279–1287)Kyle H. Molberg, Clara Heffess, Ruby Delgado and Jorge Albores-Saavedra
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1279::AID-CNCR10>3.0.CO;2-3
One periampullary and nine undifferentiated pancreatic carcinomas with osteoclast-like giant cells are reported. Immunohistochemical studies revealed that the neoplastic cells displayed epithelial differentiation; however, the osteoclast-like giant cells showed a histiocytic phenotype and were probably reactive. Most of the patients died of tumor within 1 year; however, 1 patient survived 14 years after surgical excision.
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A southwest oncology group and cancer and leukemia group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in Adults with advanced osteosarcoma, ewing's sarcoma, and rhabdomyosarcoma (pages 1288–1295)Karen Antman, John Crowley, Stanley P. Balcerzak, Raymond A. Kempf, Raymond B. Weiss, Gerald H. Clamon and Laurence H. Baker
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1288::AID-CNCR11>3.0.CO;2-2
Chemotherapy using a combination of doxorubicin, dacarbazine, ifosfamide, and mesna is an active regimen in adults with advanced or metastatic Ewing's sarcoma and rhabdomyosarcoma. Approximately 10-20% of patients with rhabdomyosarcoma or Ewing's sarcoma remained disease free at 5 years.
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bcl-2 and apoptosis in lymph node positive breast carcinoma (pages 1296–1302)Melora D. Berardo, Richard M. Elledge, Carl de Moor, Gary M. Clark, C. Kent Osborne and D. Craig Allred
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1296::AID-CNCR12>3.0.CO;2-1
High bcl-2 expression identifies a more indolent phenotype of lymph node positive breast carcinoma. Unexpectedly, bcl-2 expression is not associated with apoptosis in the primary tumor.
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Treatment outcome with radiation therapy after breast augmentation or reconstruction in patients with primary breast carcinoma (pages 1303–1309)Sandra J. Victor, Douglas M. Brown, Eric M. Horwitz, Alvaro A. Martinez, Vijay R. Kini, Jane E. Pettinga, Kenneth W. Shaheen, Pamela Benitez, Peter Y. Chen and Frank A. Vicini
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1303::AID-CNCR13>3.0.CO;2-A
The majority of patients diagnosed with breast carcinoma with prosthetically augmented breasts and many patients with reconstructed breasts can be treated with radiation therapy with the expectation of good to excellent cosmetic results. The use of bolus, advanced disease stage, and irradiation after reconstruction (vs. augmentation) appear to be related to a worsened cosmetic outcome.
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Breast carcinoma survival analysis for african american and white women in an equal-access health care system (pages 1310–1318)Barbara E. Wojcik, Martha K. Spinks and Scott A. Optenberg
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1310::AID-CNCR14>3.0.CO;2-9
This statistical analysis of the medical records of 6577 women demonstrated that African American women with ready access to definitive medical care have significantly better chances of surviving breast carcinoma than the general population of African American women represented in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute.
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Telomerase activity and expression of its RNA component in cervical lesions (pages 1319–1327)Kazuo Yashima, Raheela Ashfaq, Jan Nowak, Vivian Von Gruenigen, Sara Milchgrub, Asha Rathi, Jorge Albores-Saavedra, Jerry W. Shay and Adi F. Gazdar
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1319::AID-CNCR15>3.0.CO;2-9
Telomerase enzyme activity and expression of its RNA component are dysregulated during the multistage pathogenesis of cervical carcinoma. The dysregulation is independent of human papillomavirus infection.
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Poorer survival of nulliparous women with endometrial carcinoma (pages 1328–1333)Helga B. Salvesen, Lars A. Akslen, Grethe Albrektsen and Ole E. Iversen
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1328::AID-CNCR16>3.0.CO;2-8
In this population-based study of endometrial carcinoma patients, nulliparous women had a poorer prognosis than parous women. In multivariate analysis, poorer survival was also associated with poor tumor grade and higher stage of disease.
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Predicting the outcome of radiotherapy for prostate carcinoma : A model-building strategy (pages 1334–1342)Edgar Ben-Josef, Falah Shamsa and Jeffrey D. Forman
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1334::AID-CNCR17>3.0.CO;2-7
The authors describe a model-building strategy that involves an objective and quantitative comparison of the discriminatory and predictive power of different models. By applying this strategy, the authors were able to select a model that allowed accurate prediction of failure of radiotherapy for prostate carcinoma shortly after the completion of therapy.
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Mature teratoma identified after postchemotherapy surgery in patients with disseminated nonseminomatous testicular germ cell tumors : A plea for an aggressive surgical approach (pages 1343–1351)Dirk J. A. Sonneveld, Dirk Th. Sleijfer, Heimen Schraffordt Koops, Mariel E. Keemers-Gels, Willemina M. Molenaar and Harald J. Hoekstra
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1343::AID-CNCR18>3.0.CO;2-6
Adequate surgical resection of residual metastatic retroperitoneal teratoma after chemotherapy may reduce late recurrences resulting from either growing mature teratoma or a secondary non-germ cell malignancy. The primary treatment for these recurrences is complete surgical excision, and long term follow-up is indicated for patients in whom residual teratoma is revealed during postchemotherapy surgery.
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Granulocyte-macrophage-colony stimulating factor in metastatic renal cell carcinoma : A phase II trial (pages 1352–1358)Brian I. Rini, Walter M. Stadler, Ricardo T. Spielberger, Mark J. Ratain and Nicholas J. Vogelzang
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1352::AID-CNCR19>3.0.CO;2-5
Granulocyte-macrophage-colony stimulating factor (GM-CSF) has unique and potent immunostimulatory properties. In this Phase II study, one case of prolonged stabilization of disease and two cases in which disease progression substantially slowed were observed among patients with metastatic renal cell carcinoma treated only with subcutaneous GM-CSF.
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Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer (pages 1359–1366)Hiro-omi Kanayama, Kin-ya Yokota, Yasushi Kurokawa, Yoshihide Murakami, Masaaki Nishitani and Susumu Kagawa
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1359::AID-CNCR20>3.0.CO;2-4
Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is useful in estimating tumor invasion and may enhance the accuracy of conventional parameters used to determine the prognosis of patients with bladder carcinoma.
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Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck : A population-based case-referent study in Sweden (pages 1367–1375)Freddi Lewin, Staffan E. Norell, Hemming Johansson, Per Gustavsson, Johan Wennerberg, Anders Biörklund and Lars Erik Rutqvist
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1367::AID-CNCR21>3.0.CO;2-3
In this study, multiplicative increased risk for squamous cell carcinoma of the head and neck was linked to alcohol consumption and tobacco smoking. No increased risk was found for the use of Swedish oral snuff.
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Molecular support for field cancerization in the head and neck (pages 1376–1380)William M. Lydiatt, Peter E. Anderson, Tullia Bazzana, Michelle Casale, Christopher J. Hughes, Andrew G. Huvos, Daniel D. Lydiatt and Stimson P. Schantz
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1376::AID-CNCR22>3.0.CO;2-2
To the authors' knowledge, this article is the first to report significant deletion of 9p21 in histologically normal mucosa adjacent to head and neck carcinoma. Discordant deletions also were demonstrated in squamous cell carcinoma, adjacent dysplasia, and normal mucosa, calling into question the use of the model utilizing tumor and adjacent dysplasia as a model for disease progression and premalignant lesions.
General Topic
Germ Cell Tumor
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A phase II trial of paclitaxel in refractory germ cell tumors (pages 1381–1386)Alan B. Sandler, Antonios Cristou, Susan Fox, Stephen D. Williams, Craig R. Nichols, Martine Turns and Bruce J. Roth
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1381::AID-CNCR23>3.0.CO;2-1
In this study paclitaxel demonstrated minimal activity in heavily pretreated patients with multiple, poor risk clinical features. Given the range of activity reported in other studies (13.3-26%), the role of paclitaxel in the treatment of patients with refractory germ cell tumors remains to be defined in future studies.
Pediatric Oncology
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Survival after relapse in childhood acute lymphoblastic leukemia : Impact of site and time to first relapse-the Children's Cancer Group experience (pages 1387–1395)Paul S. Gaynon, Roger P. Qu, Richard J. Chappell, Michael L. N. Willoughby, David G. Tubergen, Peter G. Steinherz and Michael E. Trigg
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1387::AID-CNCR24>3.0.CO;2-1
This report describes the survival of 1144 children with acute lymphoblastic leukemia after relapse. In this unselected but heterogeneously treated population, substantial survival is evident among several subsets, namely, those with isolated or combined bone marrow relapse after 36 months and those with isolated extramedullary relapse at any time.
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Increased incidence of cancer in infants in the U. S.: 1980-1990 (pages 1396–1400)Lisa B. Kenney, Barry A. Miller, Lynn A. Gloeckler Ries, H. Stacy Nicholson, Julianne Byrne and Gregory H. Reaman
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980401)82:7<1396::AID-CNCR25>3.0.CO;2-0
Children age < 1 year in the U.S. had an increased incidence of cancer between 1980-1990.
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