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Cancer

Cover image for Cancer

15 April 1998

Volume 82, Issue 8

Pages 1419–1608

  1. Review Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
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      Utilization of polymerase chain reaction technology in the detection of solid tumors (pages 1419–1442)

      Ganesh V. Raj, Jose G. Moreno and Leonard G. Gomella

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1419::AID-CNCR1>3.0.CO;2-4

      Polymerase chain reaction techniques can detect small numbers of cancer cells that are not detectable by current routinely employed methods. The utility of this assay as a clinical and research tool remains an area of active investigation in the study of many solid tumors.

  2. Original Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    1. Anatomic Site

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      Tumor thickness predicts cervical metastasis in patients with stage I/II carcinoma of the tongue (pages 1443–1448)

      Takahiro Asakage, Tomoyuki Yokose, Kiyoshi Mukai, Shoichiro Tsugane, Yoshitaka Tsubono, Masao Asai and Satoshi Ebihara

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1443::AID-CNCR2>3.0.CO;2-A

      Multivariate analysis demonstrated that only tumor thickness had a predictive value for cervical metastasis and influenced disease free survival in patients with Stage I/II carcinoma of the tongue. The results of this study clearly demonstrate that conservative supraomohyoid neck dissection is indicated for patients with Stage I/II carcinoma of the tongue > 4 mm in thickness.

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      Epstein-barr virus detection in nasopharyngeal tissues of patients with suspected nasopharyngeal carcinoma (pages 1449–1453)

      Sen-Tien Tsai, Ying-Tai Jin, Risa B. Mann and Richard F. Ambinder

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1449::AID-CNCR3>3.0.CO;2-4

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      EBER in situ hybridization of nasopharyngeal tissues is sensitive and specific for the diagnosis of nasopharyngeal carcinoma.

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      The clinicopathologic significance of small areas unstained by lugol's iodine in the mucosa surrounding resected esophageal carcinoma : An analysis of 147 cases (pages 1454–1459)

      Yukihiro Nakanishi, Atsushi Ochiai, Kimio Yoshimura, Hoichi Kato, Tadakazu Shimoda, Hajime Yamaguchi, Yuji Tachimori, Hiroshi Watanabe and Setsuo Hirohashi

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1454::AID-CNCR4>3.0.CO;2-9

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      There was a higher incidence of small areas unstained by Lugol's iodine, most of which showed epithelial changes regarded as dysplasia, in the mucosa surrounding resected esophageal carcinoma. This correlated significantly with heavier consumption of alcohol and the development of multiple primary cancers in the upper aerodigestive tract.

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      Treatment of patients with advanced gastric carcinoma with a 5-fluorouracil-based or a cisplatin-based regimen : Two parallel randomized phase II studies (pages 1460–1467)

      Carlo Barone, Domenico C. Corsi, Carmelo Pozzo, Alessandra Cassano, Tecla Fontana, Maria R. Noviello, Matteo Landriscina, Giuseppe Colloca and Antonio Astone

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1460::AID-CNCR5>3.0.CO;2-D

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      These two parallel randomized Phase II studies show similar outcomes. Performance status and other prognostic factors appear to be more important determinants of response and survival than the chemotherapy schedule in patients with advanced gastric carcinoma. Patients with poor performance status should be treated only in clinical studies.

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      Interrelation between tumor-associated cell surface glycoprotein and host immune response in gastric carcinoma patients (pages 1468–1475)

      Toshiro Okuyama, Yoshihiko Maehara, Yoshihiro Kakeji, Shunichi Tsujitani, Daisuke Korenaga and Keizo Sugimachi

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1468::AID-CNCR6>3.0.CO;2-5

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      Patients with a marked infiltration of S-100 protein positive dendritic cells had a better prognosis than the slight progress observed in patients with Helix pomatia agglutinin positive gastric carcinoma.

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      Factors associated with the use of flexible sigmoidoscopy as a screening test for the detection of colorectal carcinoma by primary care physicians (pages 1476–1481)

      Gregory S. Cooper, Richard H. Fortinsky, Ronald Hapke and C. Seth Landefeld

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1476::AID-CNCR7>3.0.CO;2-7

      In a large survey of primary care physicians, sigmoidoscopic screening was offered by most practitioners, but many did not perform the procedure themselves. Poor patient acceptance was the most frequently cited deterrent to screening, suggesting that both physician training and patient education are needed to promote the use of sigmoidoscopic screening.

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      Lymph node harvest reporting in patients with carcinoma of the large bowel : A French population-based study (pages 1482–1486)

      Jean Maurel, Guy Launoy, Pascale Grosclaude, Marc Gignoux, Patrick Arveux, Hélène Mathieu-Daudé, Nicole Raverdy and Jean Faivre

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1482::AID-CNCR8>3.0.CO;2-B

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      This French population-based study reports the risk of misclassification and understaging in lymph node harvest reporting in patients with carcinoma of the large bowel.

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      The establishment of a preoperative diagnosis of pancreatic carcinoma using cell specimens from pancreatic duct brushing with special attention to p53 mutations (pages 1487–1494)

      Toshiyasu Iwao, Keiji Hanada, Akira Tsuchida, Manabu Hirata, Noriaki Eguchi and Goro Kajiyama

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1487::AID-CNCR9>3.0.CO;2-6

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      p53 immunocytology reflects its gene mutations precisely. The combination of immunocytologic and genetic analysis of p53 and the conventional cytologic procedure using the cell specimens obtained by selective endoscopic pancreatic duct brushing is available for the preoperative diagnosis of patients with pancreatic carcinoma.

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      Estrogen-receptor-related protein p29 in primary nonsmall cell lung carcinoma : Pathologic and prognostic correlations (pages 1495–1500)

      Sara O. Vargas, Kevin O. Leslie, Pamela M. Vacek, Mark A. Socinski and Donald L. Weaver

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1495::AID-CNCR10>3.0.CO;2-#

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      Estrogen-receptor-related protein p29 was identified immunohistochemically in 109 of 111 tumors (98%) from patients with primary nonsmall cell carcinoma of the lung. The intensity of staining correlated negatively with length of survival for female patients in the study and this association was more pronounced for patients with Stage I and II tumors.

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      Primary systemic amyloidosis with delayed progression to multiple myeloma (pages 1501–1505)

      S. Vincent Rajkumar, Morie A. Gertz and Robert A. Kyle

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1501::AID-CNCR11>3.0.CO;2-8

      Like monoclonal gammopathy of undetermined significance, primary amyloidosis occasionally progresses to multiple myeloma.

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      Assessment of pulmonary and cardiac function after high dose chemotherapy with BEAM and peripheral blood progenitor cell transplantation (pages 1506–1512)

      Emile Salloum, Anand P. Jillella, Rajani Nadkarni, Stuart Seropian, Grace L. Hu, Elizabeth D'Andrea, Daniel Zelterman and Dennis L. Cooper

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1506::AID-CNCR12>3.0.CO;2-8

      Equilibrium radionuclide angiography and pulmonary function testing were performed on 26 patients with Hodgkin's disease or non-Hodgkin's lymphoma before and after high dose therapy with peripheral blood progenitor cell support. No significant cardiac or pulmonary toxicity was found, even in patients with borderline pretransplantation pulmonary function tests.

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      Expression of c-met is a strong independent prognostic factor in breast carcinoma (pages 1513–1520)

      Rola A. D. Ghoussoub, Deborah A. Dillon, Thomas D'Aquila, Eric B. Rimm, Eric R. Fearon and David L. Rimm

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1513::AID-CNCR13>3.0.CO;2-7

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      Strong expression of met, the receptor for hepatocyte growth factor, in invasive ductal carcinoma of the breast predicts significantly worse 5-year survival, independent of metastases to lymph nodes or estrogen receptor status.

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      Results of intermediate measures from a population-based, randomized trial of mammographic screening prevalence and detection of breast carcinoma among asian women : The Singapore breast screening project (pages 1521–1528)

      Eng-Hen Ng, Fook-Cheong Ng, Puay-Hoon Tan, Sze-Chuan Low, Gilbert Chiang, Kim-Ping Tan, Adelene Seow, Shanta Emmanuel, Chor-Hiang Tan and Gay-Hui Ho

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1521::AID-CNCR14>3.0.CO;2-6

      In this randomized, population-based mammographic screening trial, 28,231 women ages 50-64 years in Singapore had 2-view mammography without physical examination. Screening detected 3.6 times (prevalence ratio) more cancers than were detected in 97,294 women not invited to have screening. The majority of cancers detected by screening were early stage, with 64% either ductal carcinoma in situ (26%) or Stage I disease (38%); this majority was significantly greater than the corresponding 26% in women not invited to have screening (P < 0.001). These positive results of intermediate measures suggest that mammographic screening may be beneficial in Asian communities with a rising incidence of breast carcinoma.

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      Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma in pregnancy : A report of two cases and review of issues specific to the management of cervical carcinoma in pregnancy including planned delay of therapy (pages 1529–1534)

      Krishnansu Tewari, Fabio Cappuccini, Angela Gambino, Matthew F. Kohler, Sergio Pecorelli and Philip J. DiSaia

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1529::AID-CNCR15>3.0.CO;2-6

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      Neoadjuvant chemotherapy may control disease progression in pregnant women diagnosed with locally advanced cervical carcinoma remote from delivery.

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      Primary heterologous carcinosarcoma (Metaplastic carcinoma) of the urinary bladder : A clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature (pages 1535–1549)

      Laurent Perret, Pascal Chaubert, Daniel Hessler and Louis Guillou

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1535::AID-CNCR16>3.0.CO;2-5

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      Primary heterologous carcinosarcomas of the urinary bladder are highly malignant neoplasms that are most often in an advanced stage at presentation. They occur predominantly in elderly males and are proven to be rapidly lethal regardless of treatment. Histogenetically, some heterologous carcinosarcomas should be regarded as a variant of sarcomatoid carcinoma (metaplastic carcinoma) that shows prominent heterologous differentiation.

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      Mitosis identification in diffuse gliomas : Implications for tumor grading (pages 1550–1555)

      Stephen W. Coons and Dennis K. Pearl

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1550::AID-CNCR17>3.0.CO;2-3

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      The identification of mitotic activity is an important factor in determining the histologic grade of a glioma. In this study, the diligence of the search for mitoses and the sample size necessary for accurate grading were evaluated.

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      Nonnasopharyngeal lymphoepithelioma of the head and neck (pages 1556–1562)

      Praveen Dubey, Chul S. Ha, K. Kian Ang, Adel K. El-Naggar, Calvin Knapp, Robert M. Byers and William H. Morrison

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1556::AID-CNCR18>3.0.CO;2-3

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      The records of 34 patients with nonnasopharyngeal lymphoepithelioma of the head and neck treated at a single institution were analyzed. The disease was demonstrated to be radiosensitive; thus, it was concluded that radiotherapy should be the mainstay of locoregional therapy.

    18. General Topic

      Disseminated Intravascular Coagulation
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      Generation of a monoclonal antibody that inhibits the procoagulant activity of various cancer cell lines (pages 1563–1569)

      Haruhiko Inufusa, Toshiyuki Adachi, Motoyuki Suzuki, Osamu Ando, Tsunetaka Ohta, Masashi Kurimoto, Yoshihiro Nakatani, Masato Nakamura and Masayuki Yasutomi

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1563::AID-CNCR19>3.0.CO;2-2

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      In this study, the authors generated a new monoclonal antibody, FS01, that recognizes and specifically inhibits the activity of cancer cell-derived blood coagulating activity 1 (CCA-1), and reacts with various cancer cell lines. CCA-1 is believed to play a major role in cancer cell-derived procoagulant activity.

    19. Medical Ethics and Advance Directives
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      The cancer specific advance directive (pages 1570–1577)

      Scott R. Berry and Peter A. Singer

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1570::AID-CNCR20>3.0.CO;2-0

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      A cancer specific advance directive has been developed and found to be preferable to a generic advance directive by oncology outpatients. The cancer specific advance directive could be used in an advance care planning program for cancer patients.

    20. Mesothelioma
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      Dihydro-5-azacytidine and cisplatin in the treatment of malignant mesothelioma : A phase II study by the Cancer and Leukemia Group B (pages 1578–1584)

      Brian L. Samuels, James Herndon II, David C. Harmon, Robert Carey, Joseph Aisner, Joseph M. Corson, Yasunosuke Suzuki, Mark R. Green and Nicholas J. Vogelzang

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1578::AID-CNCR21>3.0.CO;2-0

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      The response rate of 29 advanced mesothelioma patients to dihydro-5-azacytidine plus cisplatin was 17%. This was not significantly different from the response rates observed when the individual drugs were used as single agents.

    21. Neuroendocrine-Related Tumors
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      The role of glucagon administration in the diagnosis and treatment of patients with tumor hypoglycemia (pages 1585–1592)

      Ana Oliveira Hoff and Rena Vassilopoulou-Sellin

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1585::AID-CNCR22>3.0.CO;2-#

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      Glucagon infusion can clarify the etiology of and be an effective treatment for hypoglycemia in patients with neoplastic diseases.

    22. Pediatric Oncology
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      Neuroblastoma screening in the united states : Results of the Texas Outreach Program for neuroblastoma screening (pages 1593–1602)

      Joann L. Ater, Kristina L. Gardner, Lewis E. Foxhall, Brad L Therrell Jr. and W. Archie Bleyer

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1593::AID-CNCR23>3.0.CO;2-Z

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      An enzyme-linked immunoadsorbent assay using the monoclonal antibody for homovanillic acid and vanillylmandelic acid accurately detected neuroblastomas in a mass screening of infants ages 5-10 months. Parental compliance to screening was poor, with the highest rates achieved in public health clinics devoted to preventive care.

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      Neurodevelopmental anomalies in children with neuroblastoma (pages 1603–1608)

      Julie Blatt and Ronald L. Hamilton

      Version of Record online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980415)82:8<1603::AID-CNCR24>3.0.CO;2-7

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      Children with neuroblastoma have an increased incidence of abnormalities of brain cytoarchitecture, particularly focal cortical dysplasia. These abnormalities are generally asymptomatic and are diagnosed by histopathologic examination. The idea that neuroblastoma may occur in the setting of a more global defect in neurodevelopment is consistent with these findings.

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