Anatomic Site
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Telomerase activity in precancerous hepatic nodules (pages 1831–1838)Prodromos Hytiroglou, Vassiliki Kotoula, Swan N. Thung, Maria Tsokos, M. Isabel Fiel and Constantine S. Papadimitriou
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1831::AID-CNCR4>3.0.CO;2-Q
Precancerous hepatic nodules exhibit telomerase activity levels similar to those of hepatocellular carcinomas. However, telomerase activity cannot be used as a marker of malignant transformation in hepatocarcinogenesis because it also may be present in large regenerative nodules.
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Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy (pages 1839–1849)Wataru Kimura, Keita Morikane, Yukiyoshi Esaki, Wing Chung Chan and Parviz M. Pour
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1839::AID-CNCR5>3.0.CO;2-I
The authors report two microscopic pancreatic ductal adenocarcinomas found incidentally at autopsy. The common characteristic of both cancers was the invasion of islets and nerves, which indicated that the cancers were malignant from their inception. These cancers and the altered ductal epithelia adjacent to them showed mutation of the c-Ki-ras oncogene. The results of this study indicate that c-Ki-ras mutation is an early event in pancreatic carcinogenesis and that the most effective way to fight against this cancer is to prevent its induction.
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Evaluation of tissue polypeptide specific antigen, CYFRA 21-1, and carcinoembryonic antigen in nonsmall cell lung carcinoma : Does the combined use of cytokeratin markers give any additional information? (pages 1850–1859)Benjamin Nisman, Joel Lafair, Norman Heching, Olga Lyass, Mario Baras, Tamar Peretz and Vivian Barak
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1850::AID-CNCR6>3.0.CO;2-R
The combined use of cytokeratin markers CYFRA 21-1 and tissue polypeptide specific antigen may provide useful information about the prognoses of patients with nonsmall cell lung carcinoma.
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The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma (pages 1860–1866)Roberto Stasi, Maurizio Brunetti, Albertina Parma, Claudio Di Giulio, Edmondo Terzoli and Adalberto Pagano
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1860::AID-CNCR7>3.0.CO;2-R
Elevated concentrations of soluble interleukin-6 (sIL-6R) are associated significantly with shorter survival in patients with multiple myeloma. Improved patient stratification may be obtained by combining sIL-6R and β2-microglobulin levels.
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The cost-effectiveness of fine-needle aspiration cytology and 14-gauge core needle biopsy compared with open surgical biopsy in the diagnosis of breast carcinoma (pages 1867–1873)Wende Logan-Young, Andrea E. Dawson, David C. Wilbur, Eduardo E. Avila, Zygmunt M. Tomkiewicz, Lucy A. Sheils, John A. Laczin and Andrea S. Taylor
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1867::AID-CNCR8>3.0.CO;2-K
A freestanding breast clinic's use of fine-needle aspiration cytology and 14-gauge core needle biopsy was found to be a cost-effective way to spare women from unnecessary open surgical biopsies without compromising breast carcinoma detection. Utilization of these methods resulted in a cost savings of > $1,000,000 in 1 year.
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Preoperative galactography increases the diagnostic yield of major duct excision for nipple discharge (pages 1874–1880)Kimberly J. Van Zee, Gloria Ortega Pérez, Emery Minnard and Michael A. Cohen
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1874::AID-CNCR9>3.0.CO;2-N
In the evaluation of nipple discharge, localization of the causative lesion by preoperative galactography increased the likelihood that the causative pathology was found at surgery from 67% to 100% (P = 0.009).
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Clinical application of intratumoral blood flow study in patients with endometrial carcinoma (pages 1881–1886)Wen-Fang Cheng, Tzer-Ming Chen, Chi-An Chen, Chih-Cheng Wu, Kuang-Ta Huang, Chang-Yao Hsieh and Fon-Jou Hsieh
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1881::AID-CNCR10>3.0.CO;2-P
Intratumoral blood flow using color Doppler ultrasound can predict pelvic lymph node metastasis in patients with endometrial carcinoma.
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Assessment of outcome prediction models for patients with localized prostate carcinoma managed with radical prostatectomy or external beam radiation therapy (pages 1887–1896)Anthony V. D'Amico, April Desjardin, Arnold Chung, Ming-Hui Chen, Delray Schultz, Richard Whittington, S. Bruce Malkowicz, Alan Wein, John E. Tomaszewski, Andrew A. Renshaw, Kevin Loughlin and Jerome P. Richie
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1887::AID-CNCR11>3.0.CO;2-P
A clinical staging system for patients with localized prostate carcinoma based on parameters obtained during routine workup provided a statistically and clinically significant stratification of outcome after either radical prostatectomy or external beam radiation therapy.
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Selective expression of inducible nitric oxide synthase in human prostate carcinoma (pages 1897–1903)Theo Klotz, Wilhelm Bloch, Christoph Volberg, Udo Engelmann and Klaus Addicks
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1897::AID-CNCR12>3.0.CO;2-O
Human prostate carcinoma cells express inducible nitric oxide synthase (iNOS), whereas benign hyperplastic prostatic tissue shows no expression of iNOS.
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Rapid screening for psychologic distress in men with prostate carcinoma : A pilot study (pages 1904–1908)Andrew J. Roth, Alice B. Kornblith, Laure Batel-Copel, Elizabeth Peabody, Howard I. Scher and Jimmie C. Holland
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1904::AID-CNCR13>3.0.CO;2-X
Screening for distress identifies a significant level of psychologic distress in men with prostate carcinoma, yet these patients are reluctant to accept psychologic intervention. Identifying the barriers contributing to this reluctance will be important in helping these men and their families cope better with this disease.
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Pathologic seminal vesicle invasion after radical prostatectomy for patients with prostate carcinoma : Effect of early adjuvant radiation therapy on biochemical control (pages 1909–1914)Richard K. Valicenti, Leonard G. Gomella, Mohammed Ismail, S. Grant Mullholland, Robert O. Petersen and Benjamin W. Corn
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1909::AID-CNCR14>3.0.CO;2-X
In this study, men with pT3cN0 prostate carcinoma were evaluated to determine the effect of local adjuvant radiation therapy on the likelihood of future biochemical failure.
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Management of recurrent meningeal hemangiopericytoma (pages 1915–1920)Evanthia Galanis, Jan C. Buckner, Bernd W. Scheithauer, David W. Kimmel, Paula J. Schomberg and David G. Piepgras
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1915::AID-CNCR15>3.0.CO;2-W
The majority of meningeal hemangiopericytomas recur in the central nervous system (CNS) (94%), whereas systemic metastases are observed in 56% of cases. The mainstay of treatment is surgery. Stereotactic radiosurgery has an important role in the treatment of smaller or medium sized CNS lesions.
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Expression of the neural cell adhesion molecule in astrocytic tumors : An inverse correlation with malignancy (pages 1921–1931)Hikaru Sasaki, Kazunari Yoshida, Eiji Ikeda, Hiroaki Asou, Makoto Inaba, Mitsuhiro Otani and Takeshi Kawase
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1921::AID-CNCR16>3.0.CO;2-V
Expression of the neural cell adhesion molecule (NCAM) in human astrocytic tumors was studied and compared with the degree of malignancy of the tumors. To the authors' knowledge, this study provides the first direct evidence that NCAM is down-regulated in the malignant evolution of astrocytic tumors; and it is suggested that reduced NCAM expression might be involved in the development of the biologic malignancy of these tumors.
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How tumor stage affects surgeons' surveillance strategies after surgery for carcinoma of the upper aerodigestive tract (pages 1932–1937)Frank E. Johnson, Katherine S. Virgo, Marc F. Clemente, Michael H. Johnson and Randal C. Paniello
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1932::AID-CNCR17>3.0.CO;2-U
A survey of two surgical societies revealed that surveillance after surgery for carcinoma of the upper aerodigestive tract is largely unaffected by TNM stage.
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A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation (pages 1938–1945)Carla Ripamonti, Ernesto Zecca, Cinzia Brunelli, Fabio Fulfaro, Sergio Villa, Augusta Balzarini, Emilio Bombardieri and Franco De Conno
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1938::AID-CNCR18>3.0.CO;2-U
In patients with head and neck cancer undergoing radiotherapy, zinc sulfate, administered orally after meals at a dose of 45 mg 3 times a day, slowed down the worsening and accelerated the recovery of taste acuity in clinically and statistically relevant ways, without adverse effects.
General Topic
Lymphoma, Extranodal
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Systemic chemotherapy alone for patients with non-acquired immunodeficiency syndrome-related central nervous system lymphoma : A pilot study of the BOMES protocol (pages 1946–1951)Ann-Lii Cheng, Kun-Huei Yeh, Wu-Ching Uen, Ruey-Long Hung, Mei-Ying Liu and Chiu-Hwa Wang
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1946::AID-CNCR19>3.0.CO;2-T
Systemic chemotherapy alone with a novel protocol containing carmustine, vincristine, methotrexate and leucovorin rescue, etoposide, and methylprednisolone in 19 patients with central nervous system lymphoma resulted in a 58% complete remission rate and long term disease free survival in 4 patients.
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A multivariate analysis of the survival of patients with aggressive lymphoma : Variations in the predictive value of prognostic factors during the course of the disease (pages 1952–1962)Nicolas Mounier, Pierre Morel, Corinne Haioun, Bertrand Coiffier, Herve Tilly, Christian Chatelain, Pierre Lederlin, Antoine Thyss, Raoul Herbrecht, Christian Gisselbrecht and Eric Lepage
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1952::AID-CNCR20>3.0.CO;2-R
In this study of the Groupe d'Etude des Lymphomes de l'Adulte, an extension of the Cox proportional hazards model was used to determine changes in the prognostic value of covariates as time progressed. Performance status, lactate dehydrogenase level, tumor stage, and number of extranodal sites were independently predictive of short term survival; however, only performance status was predictive of a patient's ability to tolerate induction chemotherapy, and only tumor stage was predictive of long term survival.
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Hemophagocytic syndrome in five patients with epstein-barr virus negative B-cell lymphoma (pages 1963–1972)Tatsuharu Ohno, Naoki Miyake, Shigefusa Hada, Yuko Hirose, Akihiro Imura, Toshiyuki Hori, Takashi Uchiyama, Tatsuyoshi Saiga, Takashi Mizumoto and Hiroo Furukawa
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1963::AID-CNCR21>3.0.CO;2-Q
In patients with B-cell lymphoma, Epstein-Barr virus (EBV) infection is not necessarily required to induce hemophagocytic syndrome (HPS). This finding may provide new insight into the understanding of the development of HPS, in which EBV-infected T-cell proliferation has been believed to play a significant role.
Pediatric Oncology
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Mass screening for neuroblastoma targeting children age 14 months in sapporo city : A preliminary report (pages 1973–1977)Motoi Nishi, Hirotsugu Miyake, Takeo Takeda, Junji Hanai, Yuko Kikuchi and Toshinori Hirama
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1973::AID-CNCR22>3.0.CO;2-P
Mass screening of children age 14 months for neuroblastoma detects those cases missed or unscreened by the screening at age 6 months, though the detection rate appears to be in excess of what would be expected.
Posttransplantation Lymphoproliferative Disorders
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The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant (pages 1978–1987)Amy Chadburn, Jonathan M. Chen, Daphne T. Hsu, Glauco Frizzera, Ethel Cesarman, Thomas J. Garrett, J. Gregory Mears, Steven D. Zangwill, Linda J. Addonizio, Robert E. Michler and Daniel M. Knowles
Article first published online: 31 OCT 2000 | DOI: 10.1002/(SICI)1097-0142(19980515)82:10<1978::AID-CNCR23>3.0.CO;2-P
The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders (PT-LPDs)-plasmacytic hyperplasia, polymorphic PT-LPD, and malignant lymphoma/multiple myeloma-are clinically relevant. This conclusion is based on statistically significant differences in clinical outcome.
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