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Cancer

Cover image for Cancer

15 June 1998

Volume 82, Issue 12

Pages 2299–2481

  1. Review Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
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      Controlled-release morphine tablets in patients with chronic cancer pain : A narrative review of controlled clinical trials (pages 2299–2306)

      Carol A. Warfield

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2299::AID-CNCR1>3.0.CO;2-O

      Although controlled-release morphine tablets often are prescribed for dosing every 8 hours, a review of the published, well controlled studies of cancer patients showed that this formulation controlled pain when administered every 12 hours. There was little need for rescue medication, and few patients discontinued its use because of side effects.

  2. Original Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    1. Anatomic Site

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      Long term survival of patients with stage IV gastric carcinoma (pages 2307–2311)

      Yoshihiro Kakeji, Yoshihiko Maehara, Masaaki Tomoda, Akira Kabashima, Mariko Ohmori, Shinya Oda, Shinji Ohno and Keizo Sugimachi

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2307::AID-CNCR2>3.0.CO;2-P

      Even patients with Stage IV gastric carcinoma who are treated with radical gastrectomy and extensive lymph node dissection can attain long term survival. p53 overexpression is a pertinent prognostic factor in these patients.

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      Race, treatment, and survival among colorectal carcinoma patients in an equal-access medical system (pages 2312–2320)

      Jason A. Dominitz, Gregory P. Samsa, Pamela Landsman and Dawn Provenzale

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2312::AID-CNCR3>3.0.CO;2-U

      Race was not associated with the use of surgery, chemotherapy, or radiation therapy in the treatment of colorectal carcinoma among veterans seeking health care in an equal-access setting. Mortality was modestly increased among African American veterans with colorectal carcinoma.

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      A phase II trial of 5-fluorouracil, leucovorin, and carboplatin in patients with unresectable biliary tree carcinoma (pages 2321–2325)

      Pedro M. Sanz-Altamira, Karen Ferrante, Roger L. Jenkins, W. David Lewis, Mark S. Huberman and Keith E. Stuart

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2321::AID-CNCR4>3.0.CO;2-V

      A combination regimen of leucovorin-modulated 5-fluorouracil with carboplatin produces significant objective responses in patients with biliary tree carcinoma with a response rate of 21.4%, is well tolerated, and should be considered for treatment of patients with unresectable tumors.

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      Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma (pages 2326–2333)

      Lynn Rosenberg, Carol Louik and Samuel Shapiro

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2326::AID-CNCR5>3.0.CO;2-Q

      Regular, continuing use of both aspirin and nonaspirin nonsteroidal antiinflammatory drugs was related to a statistically significant reduction in the relative risk of large bowel carcinoma in a population-based study of 1201 cases and 1201 matched community controls. The relative risk estimate (0.7 overall and 0.6 for disease diagnosed at Stages II through IV) did not appear to be influenced by the duration of use or by the dose of aspirin.

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      Epstein-barr virus-associated nonsmall cell lung carcinoma : Undifferentiated "lymphoepithelioma-like" carcinoma as a distinct entity with better prognosis (pages 2334–2342)

      Fen-Fen Chen, Jing-Jou Yan, Wu-Wei Lai, Ying-Tai Jin and Ih-Jen Su

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2334::AID-CNCR6>3.0.CO;2-S

      This article analyzes the correlation between Epstein-Barr virus-encoded RNA-1 expression, clinical parameters, and bcl-2 expression in lung carcinoma.

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      Relation between cellular doxorubicin binding ability to nuclear DNA and histologic response to preoperative chemotherapy in patients with osteosarcoma (pages 2343–2349)

      Katsuyuki Kusuzaki, Hideyuki Takeshita, Hiroaki Murata, Masazumi Hirata, Shin Hashiguchi, Tsukasa Ashihara and Yasusuke Hirasawa

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2343::AID-CNCR7>3.0.CO;2-T

      Doxorubicin binding to nuclear DNA in tumor cells, analyzed by doxorubicin (Adriamycin) binding assay (ABA), was found to be closely correlated with histologic response to preoperative chemotherapy in patients with osteosarcoma. ABA also is technically simple, and the results can be assessed rapidly. The authors concluded that ABA is a useful chemosensitivity test for patients with osteosarcoma that is more reliable and clinically more useful than many of the tests reported previously.

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      Mesenchymal chondrosarcoma of the jaw bones : Clinicopathologic study of 19 cases (pages 2350–2355)

      Eneida F. Vencio, Charles M. Reeve, K. Krishnan Unni and Antonio G. Nascimento

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2350::AID-CNCR8>3.0.CO;2-W

      Mesenchymal chondrosarcoma of the jaw bones appears to run a more indolent clinical course than mesenchymal chondrosarcoma occurring elsewhere.

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      Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma (pages 2356–2365)

      Patrick P. Lin, Karen D. Schupak, Patrick J. Boland, Murray F. Brennan and John H. Healey

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2356::AID-CNCR9>3.0.CO;2-Q

      The femur is at high risk of fracture when resection of a soft tissue sarcoma includes periosteum and radiation is used as an adjuvant therapy. Postmenopausal female patients and patients undergoing chemotherapy are at especially high risk of fracture.

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      Inflammatory breast carcinoma incidence and survival : The Surveillance, Epidemiology, and End Results program of the National Cancer Institute, 1975-1992 (pages 2366–2372)

      Shine Chang, Sheryl L. Parker, Tuan Pham, Aman U. Buzdar and Stephen D. Hursting

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2366::AID-CNCR10>3.0.CO;2-N

      In data from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute, increasing incidence rates and improved survival over time were observed for women diagnosed with inflammatory breast carcinoma (IBC) for the period 1975-1992. Ethnic differences in age at diagnosis between women with IBC and women with other types of breast carcinoma were also observed.

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      The extent of proliferative and apoptotic activity in intraductal and invasive ductal breast carcinomas detected by ki-67 labeling and terminal deoxynucleotidyl transferase-mediated digoxigenin-11-dUTP nick end labeling (pages 2373–2381)

      Kuo-Liang Shen, Horng-Jyh Harn, Li-Ing Ho, Cheng-Ping Yu, Shao-Chih Chiu and Wei-Hwa Lee

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2373::AID-CNCR11>3.0.CO;2-M

      The results of this study indicate that a higher degree of apoptosis and lower proliferation activity in intraductal carcinoma result in a steady-state, self-renewing condition in which net growth of the tumor is rare. Apoptosis is evidently altered by the expression of p53, bcl-2, estrogen receptor, and progesterone receptor.

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      Mammary ductal carcinoma in Situ with microinvasion (pages 2382–2390)

      Susan A. Silver and Fattaneh A. Tavassoli

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2382::AID-CNCR12>3.0.CO;2-L

      As evaluated in this study, intraductal carcinoma with microinvasion (defined as a single focus of invasive carcinoma ≤2 mm or up to 3 foci of invasion, each ≤1 mm in greatest dimension) is not associated with axillary lymph node metastases and, based on a mean follow-up of 7.5 years, appears to be associated with an excellent prognosis.

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      How reminders given to patients and physicians affected pap smear use in a health maintenance organization : Results of a randomized controlled trial (pages 2391–2400)

      Robert C. Burack, Phyllis A. Gimotty, Julie George, Scott McBride, Anita Moncrease, Michael S. Simon, Peter Dews and Jennifer Coombs

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2391::AID-CNCR13>3.0.CO;2-K

      In a randomized controlled trial that involved a health maintenance organization (HMO) serving inner city women, reminders mailed to patients and placed in physicians' medical records had a limited impact on rates of visitation by patients to HMO sites and Pap smear completion. These results highlight the need to identify more effective strategies and to apply them more selectively.

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      Squamous intraepithelial lesions of the cervix, invasive cervical carcinoma, and immunosuppression induced by human immunodeficiency virus in africa (pages 2401–2408)

      Guy La Ruche, Rosa Ramon, Isabelle Mensah-Ado, Christine Bergeron, Mohenou Diomandé, Fatoumata Sylla-Koko, Armand Ehouman, Karidiata Touré-Coulibaly, Christiane Welffens-Ekra and François Dabis

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2401::AID-CNCR14>3.0.CO;2-T

      In Africa, squamous intraepithelial lesions of the cervix are prevalent and are associated with HIV-1 infection, whereas invasive cervical carcinomas are linked to HIV-2 infection. Other factors associated with cervical neoplasia, such as low educational level, multiparity, and chewing tobacco, could have implications for cervical screening programs in the future.

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      Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix : A possible immunohistochemical marker of a favorable prognosis (pages 2409–2417)

      Xin Lu, Toshihiko Toki, Ikuo Konishi, Toshio Nikaido and Shingo Fujii

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2409::AID-CNCR15>3.0.CO;2-T

      Expression of p21WAF1/CIP1 correlates significantly with a favorable prognosis for patients with cervical adenocarcinoma.

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      Interstitial fluid pressure in cervical carcinoma : Within tumor heterogeneity, and relation to oxygen tension (pages 2418–2426)

      Michael F. Milosevic, Anthony W. Fyles, Raimond Wong, Melania Pintilie, Mary-Claire Kavanagh, Wilfred Levin, Lee A. Manchul, Thomas J. Keane and Richard P. Hill

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2418::AID-CNCR16>3.0.CO;2-S

      Interstitial fluid pressure is elevated above normal tissue values and varies from region to region in cervical carcinoma. Tumors with high interstitial fluid pressure are more likely to be hypoxic and are less likely to respond completely to radiotherapy.

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      Cystic embryonal sarcoma of kidney : A case report (pages 2427–2433)

      Brett Delahunt, J. Bruce Beckwith, John N. Eble, Mark R. Fraundorfer, Timothy D. Sutton and Grant E Trotter

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2427::AID-CNCR17>3.0.CO;2-R

      The clinical and pathologic features of a case of cystic embryonal sarcoma of the kidney in a 19-year-old male are reported. The tumor was a clinically aggressive, poorly differentiated sarcoma containing dilated cysts of probable renal tubule origin.

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      Plasma glutathione S-transferase P1-1 levels in patients with head and neck squamous cell carcinoma (pages 2434–2438)

      Michael B. Oude Ophuis, Theo P. J. Mulder, Wilbert H. M. Peters and Johannes J. Manni

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2434::AID-CNCR18>3.0.CO;2-Q

      A sensitive and specific sandwich enzyme-linked immunoadsorbent assay for glutathione S-transferase-P1-1 revealed elevated plasma levels in only 13 of 93 patients (14%) with head and neck squamous cell carcinoma. In contrast to earlier reports by others, the authors of this study did not find evidence that glutathione S-transferase P1-1 was a suitable tumor marker for head and neck malignancies.

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      Application of the international prognostic index in a study of chinese patients with non-hodgkin's lymphoma and a high incidence of primary extranodal lymphoma (pages 2439–2448)

      Tony S. Mok, Joyce Steinberg, Anthony T. Chan, Winnie M. Yeo, P. Hui, Thomas W. Leung and Philip Johnson

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2439::AID-CNCR19>3.0.CO;2-Q

      The International Prognostic Index for non-Hodgkin's lymphoma is generally applicable to Chinese patients; however, among patients with a high incidence of primary extranodal lymphoma, the number of extranodal sites may not be a significant prognostic factor.

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      How should imipenem-cilastatin be Used in the treatment of fever and infection in neutropenic cancer patients? (pages 2449–2458)

      Issam I. Raad, Dima Abi-Said, Kenneth V. Rolston, Cynthia L. Karl and Gerald P. Bodey

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2449::AID-CNCR20>3.0.CO;2-O

      Imipenem-cilastatin monotherapy is adequate in treating most febrile neutropenic cancer patients. Low dose imipenem could be effective and safe in uncomplicated cases without pneumonia.

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      MIB-1 labeling index in nonpilocytic astrocytoma of childhood : A study of 101 cases (pages 2459–2466)

      Donald M. Ho, Tai-Tong Wong, Chih-Yi Hsu, Ling-Tan Ting and Hung Chiang

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2459::AID-CNCR21>3.0.CO;2-N

      MIB-1 labeling index can differentiate effectively between two different prognostic categories of pediatric anaplastic astrocytoma.

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      Informed consent in the childrens cancer group : Results of preliminary research (pages 2467–2481)

      Eric D. Kodish, Rebecca D. Pentz, Robert B. Noll, Kathy Ruccione, Jonathan Buckley and Beverly J. Lange

      Article first published online: 6 DEC 1998 | DOI: 10.1002/(SICI)1097-0142(19980615)82:12<2467::AID-CNCR22>3.0.CO;2-M

      Research regarding informed consent in pediatric cancer trials can provide important data on this complex but critical process. The authors present preliminary results and discuss their implications for a future research agenda.

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