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Cancer

Cover image for Cancer

15 July 1998

Volume 83, Issue 2

Pages 201–390

  1. Editorials

    1. Top of page
    2. Editorials
    3. Original Articles
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      Why hereditary nonpolyposis colorectal carcinoma patients appear to have better survival than patients with sporadic colorectal carcinoma (pages 201–203)

      Bernard Levin

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<201::AID-CNCR1>3.0.CO;2-T

      The genetic basis for hereditary nonpolyposis colorectal carcinoma (HNPCC) and its characteristic pathologic features are summarized. Although there is no definitive explanation for the observation that patients with HNPCC appear to have better prognoses than those with sporadic carcinoma, potential explanations are discussed. See also pages 259-66.

  2. Original Articles

    1. Top of page
    2. Editorials
    3. Original Articles
    1. Anatomic Site

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      Alterations of p53, cyclin D1, rb, and H-ras in human oral carcinomas related to tobacco use (pages 204–212)

      Jie Xu, Irma B. Gimenez-Conti, Joan E. Cunningham, Ana M. Collet, Mario A. Luna, Hector E. Lanfranchi, Margaret R. Spitz and Claudio J. Conti

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<204::AID-CNCR2>3.0.CO;2-Q

      The results of this study suggest that in oral carcinomas related to tobacco use, p53 mutations and cyclin D1 overexpression are common genetic events, whereas Rb inactivation and H-ras gene mutations are infrequent.

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      A comparison of staging systems for nasopharyngeal carcinoma (pages 213–219)

      Jay S. Cooper, Richard Cohen and Randy E. Stevens

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<213::AID-CNCR3>3.0.CO;2-R

      The authors believe a revised staging system, described in the fifth edition of the American Joint Committee on Cancer (AJCC) staging manual, separates subgroups of American patients with nasopharyngeal carcinoma more appropriately than does the fourth edition of the AJCC staging manual or the Ho staging system.

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      Mucosal iodine staining improves endoscopic visualization of squamous dysplasia and squamous cell carcinoma of the esophagus in linxian, china (pages 220–231)

      Sanford M. Dawsey, David E. Fleischer, Guo-Qing Wang, Bin Zhou, Jean A. Kidwell, Ning Lu, Klaus J. Lewin, Mark J. Roth, T. Lok Tio and Philip R. Taylor

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<220::AID-CNCR4>3.0.CO;2-U

      Two hundred twenty-five adults were examined by esophageal endoscopy with mucosal iodine staining. Before staining, the sensitivity of visible mucosal lesions for identifying high grade squamous dysplasia or invasive squamous carcinoma was 62%, and the specificity was 79%. After staining, the sensitivity of unstained areas for identifying these same lesions was 96%, and the specificity was 63%. Twenty-three percent of the patients with severe dysplasia and 55% of those with moderate dysplasia were identified only after staining.

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      Allelic deletion in 11p15 is a common occurrence in esophageal and gastric adenocarcinoma (pages 232–239)

      Christopher A. Moskaluk and Craig A. Rumpel

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<232::AID-CNCR5>3.0.CO;2-S

      An assay of polymorphic microsatellite markers revealed that esophageal adenocarcinoma shares with gastric adenocarcinoma a tendency to lose a portion of the short arm of chromosome 11. This suggests that a locus of tumor suppression in 11p15 is common in both neoplasms.

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      Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma (pages 240–244)

      Miguel A. Rodriguez-Bigas, Hans F. A. Vasen, Henry T. Lynch, Patrice Watson, Torben Myrhøj, Heikki J. Järvinen, Jukka Pekka Mecklin, Finlay Macrae, D. James B. St. John, Lucio Bertario, Paulo Fidalgo, Lisa Madlensky and Paul Rozen

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<240::AID-CNCR6>3.0.CO;2-U

      Small bowel adenocarcinoma can be the presenting neoplasm in hereditary nonpolyposis colorectal carcinoma (HNPCC). Similar to colorectal carcinoma in HNPCC, small bowel adenocarcinoma presents at an earlier age and appears to have a better prognosis than in the general population.

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      18F-labeled fluorouracil positron emission tomography and the prognoses of colorectal carcinoma patients with metastases to the liver treated with 5-fluorouracil (pages 245–253)

      Markus Moehler, Antonia Dimitrakopoulou-Strauss, Frank Gutzler, Ulrich Raeth, Ludwig G. Strauss and Wolfgang Stremmel

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<245::AID-CNCR7>3.0.CO;2-P

      Positron emission tomography (PET) is a noninvasive means of measuring the distribution and metabolism of radiolabeled cytostatic agents in tumor regions. Therefore, 18F-labeled fluorouracil (18F-FU) PET may be a new tool for predicting the therapeutic responses and prognoses of patients with colorectal carcinoma metastases to the liver prior to the administration of 5-fluorouracil (5-FU)- based chemotherapy, allowing these patients to be selected for other treatment protocols if necessary.

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      Protracted treatment with tegafur and low dose oral leucovorin in patients with advanced colorectal carcinoma (pages 254–258)

      Miquel Nogué, Miquel A. Seguí, Eugeni Saigí, Eduard Batiste-Alentorn, Angels Arcusa, Montserrat Boleda and Isabel Antón

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<254::AID-CNCR8>3.0.CO;2-Q

      An all-oral regimen of tegafur and folinic acid can obtain biochemical modulation, with a significant response rate, in patients with advanced colorectal carcinoma.

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      Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members (pages 259–266)

      Patrice Watson, Kevin M. Lin, Miguel A. Rodriguez-Bigas, Tom Smyrk, Stephen Lemon, M. Shashidharan, Barbara Franklin, Beth Karr, Alan Thorson and Henry T. Lynch

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<259::AID-CNCR9>3.0.CO;2-L

      Hereditary nonpolyposis colorectal carcinoma patients had lower stage disease at diagnosis than unselected colorectal carcinoma patients, mainly due to rarer distant metastases at diagnosis, and they survived longer than unselected colorectal carcinoma patients with tumors of the same stage. See also pages 201-3.

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      Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union (pages 267–275)

      Satoshi Tanno, Takeshi Obara, Tsuneshi Fujii, Yusuke Mizukami, Ryushi Shudo, Noriyuki Nishino, Hitoshi Ura, Andres J. P. Klein-Szanto and Yutaka Kohgo

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<267::AID-CNCR10>3.0.CO;2-R

      The results of this study suggest that hyperplasia of the gallbladder mucosa in patients with anomalous pancreaticobiliary ductal union could be a premalignant lesion of the gallbladder because it is associated with increased proliferative activity and the presence of K-ras mutations.

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      Prognostic significance of tumor necrosis factors and their receptors in nonsmall cell lung carcinoma (pages 276–282)

      Tien-Anh Tran, Bhaskar V. S. Kallakury, Robert A. Ambros and Jeffrey S. Ross

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<276::AID-CNCR11>3.0.CO;2-Q

      Nonsmall cell lung carcinoma (NSCLC) shows coexpression of tumor necrosis factors (TNF) and their receptors (TNF-α, TNF-β, TNF-R1, and TNF-R2). Positivity of TNF-R1 and TNF-R2 independently predicts favorable prognosis of patients with NSCLC.

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      A randomized trial of hybrid administration of cyclophosphamide, doxorubicin, and vincristine (CAV)/Cisplatin and etoposide (PVP) versus sequential administration of CAV-PVP for the treatment of patients with small cell lung carcinoma : Results of long term follow-up (pages 283–290)

      Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, Haruhito Kamei, Kenichi Gemba, Katsuyoshi Sakae, Yoshio Hiraki, Shunkichi Hiraki, Yoshihiko Segawa and Mine Harada

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<283::AID-CNCR12>3.0.CO;2-P

      The authors conducted a randomized trial comparing hybrid chemotherapy with cyclophosphamide, doxorubicin, and vincristine (CAV) and cisplatin and etoposide (PVP) with sequential administration of CAV and PVP for the treatment of small cell lung carcinoma. Long term follow-up revealed no advantages for the hybrid regimen in terms of response rate, toxicities, and survival.

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      Failure of fluconazole prophylaxis to reduce mortality or the requirement of systemic amphotericin B therapy during treatment for refractory acute myeloid leukemia : Results of a prospective randomized Phase III study (pages 291–301)

      Wolfgang Kern, Gerhard Behre, Thomas Rudolf, Andrea Kerkhoff, Albert Grote-Metke, Hartmut Eimermacher, Ursula Kubica, Bernhard Wörmann, Thomas Büchner and Wolfgang Hiddemann

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<291::AID-CNCR13>3.0.CO;2-O

      The efficacy of systemic antifungal prophylaxis with fluconazole in the treatment of patients with refractory acute myeloid leukemia receiving the sequential high dose cytosine arabinoside and mitoxantrone (S-HAM) regimen was evaluated in a prospective, randomized manner. The prophylaxis failed to reduce the early death rate and the requirement of systemic amphotericin B therapy and had no influence on overall survival.

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      The quality of care for treatment of early stage breast carcinoma : Is it consistent with national guidelines? (pages 302–309)

      Edward Guadagnoli, Charles L. Shapiro, Jane C. Weeks, Jerry H. Gurwitz, Catherine Borbas and Stephen B. Soumerai

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<302::AID-CNCR14>3.0.CO;2-X

      In the states studied, practice appears to be consistent with the recommendations from national consensus conferences and clinical trials regarding the treatment of early stage breast carcinoma.

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      Steroid receptors in hereditary breast carcinomas associated with BRCA1 or BRCA2 mutations or unknown susceptibility genes (pages 310–319)

      Niklas Loman, Oskar Johannsson, Pär-Ola Bendahl, Åke Borg, Mårten Fernö and Håkan Olsson

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<310::AID-CNCR15>3.0.CO;2-W

      A study of estrogen and progesterone hormone receptor levels in hereditary breast carcinomas demonstrated lower levels of steroid receptors in hereditary breast carcinomas related to BRCA1 mutations than in tumors related to other genetic causes, such as BRCA2 mutations. A subgroup of hereditary breast carcinoma patients with unidentified predisposing factors had high progesterone receptor levels.

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      Treatment options, selection, and satisfaction among african american and white men with prostate carcinoma in north carolina (pages 320–330)

      Wendy Demark-Wahnefried, Joellen M. Schildkraut, Christophe E. Iselin, Elizabeth Conlisk, Andrew Kavee, Tim E. Aldrich, Eugene J. Lengerich, Philip J. Walther and David F. Paulson

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<320::AID-CNCR16>3.0.CO;2-V

      Results of a telephone survey completed by 117 African American and 114 white men with prostate carcinoma revealed that measures related to treatment (i.e., treatment options discussed by patients with their physicians, treatment(s) received, factors influencing treatment, and satisfaction with treatments discussed and options given) were consistently associated with stage of disease at diagnosis (P < 0.001) rather than other variables measured (i.e., race, age, income, comorbidity, education, and residential status).

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      Expression of bcl-2 in testicular carcinoma : Correlation with tumor progression and MDR1/Pgp (pages 331–336)

      Hanna Eid, Miklos Gulyás, Lajos Géczi, Isrvan Bodrogi, Etel Institoris and Mihály Bak

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<331::AID-CNCR17>3.0.CO;2-U

      The expression of bcl-2 is associated with a more advanced malignant phenotype of germ cell testicular tumor.

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      Sarcoidosis and testicular carcinoma (pages 337–343)

      Daniel Rayson, Patrick A. Burch and Ronald L. Richardson

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<337::AID-CNCR18>3.0.CO;2-U

      Fourteen patients with malignant testicular tumors and sarcoidosis were reviewed. The estimated cumulative incidence of sarcoidosis in patients with testicular carcinoma seen at the Mayo Clinic between 1976 and 1995 was 617.3 per 100,000.

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      Stereotactic radiosurgery for brain metastasis from renal cell carcinoma (pages 344–353)

      Yoshimasa Mori, Douglas Kondziolka, John C. Flickinger, Theodore Logan and L. Dade Lunsford

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<344::AID-CNCR19>3.0.CO;2-T

      Stereotactic radiosurgery is a safe and effective treatment for brain metastases from renal cell carcinoma. Further comparisons with results after whole brain irradiation or tumor resection are warranted.

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      Correlation of cytogenetic abnormalities with the outcome of patients with uveal melanoma (pages 354–359)

      Valerie A. White, Jeffrey D. Chambers, Paul D. Courtright, Wilma Y. Chang and Douglas E. Horsman

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<354::AID-CNCR20>3.0.CO;2-R

      The results of a cytogenetic analysis were associated with the outcome of patients with uveal melanoma. Concurrent abnormalities of chromosomes 3 and 8 signified a poor prognosis, whereas chromosome 6 abnormalities were associated with a better prognosis.

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      Loss of material from chromosome arm 1p during malignant progression of meningioma revealed by fluorescent in Situ hybridization (pages 360–366)

      Shinsuke Ishino, Naoya Hashimoto, Shinji Fushiki, Kousei Date, Toshiki Mori, Masahito Fujimoto, Yoshio Nakagawa, Satoshi Ueda, Tatsuo Abe and Johji Inazawa

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<360::AID-CNCR21>3.0.CO;2-Q

      Investigation of the allelic status of 1p in both primary and recurrent tumors from the same patient supports the existence of tumor suppressor gene(s) on 1p associated with malignant progression of meningioma, and suggests that detection of the allelic status of chromosome 1p by fluorescent in situ hybridization may assist physicians in predicting the clinical prognosis of patients with this type of brain tumor.

    21. General Topic

      Epstein-Barr Virus
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      Expression of epstein-barr virus in patients with hodgkin's disease in taiwan (pages 367–371)

      Shian-Min Liu, Kuan-Chih Chow, Chang-Fang Chiu and Cheng-Hwai Tzeng

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<367::AID-CNCR22>3.0.CO;2-Q

      This study reveals an intermediate degree of association of Epstein-Barr virus with Hodgkin's disease (HD) in Taiwan, where the incidence of HD among the totality of lymphoma cases is low.

    22. Neuroendocrine Tumors
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      5-fluorouracil, dacarbazine, and epirubicin in the treatment of patients with neuroendocrine tumors (pages 372–378)

      Emilio Bajetta, Lorenza Rimassa, Carlo Carnaghi, Ettore Seregni, Leonardo Ferrari, Maria Di Bartolomeo, Enrico Regalia, Antonio Cassata, Giuseppe Procopio and Luigi Mariani

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<372::AID-CNCR23>3.0.CO;2-P

      The efficacy and tolerability of the FDE regimen (5-fluorouracil, dacarbazine, and epirubicin) were tested in patients with a wide variety of neuroendocrine tumors. The overall response rate was 30%, and toxicity was acceptable.

    23. Pediatric Oncology
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      Blood lipid profiles in children with acute lymphoblastic leukemia (pages 379–384)

      Jacqueline M. Halton, Darius J. Nazir, Matthew J. McQueen and Ronald D. Barr

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<379::AID-CNCR24>3.0.CO;2-P

      Blood lipid profiles observed in children with acute lymphoblastic leukemia change in relation to diagnosis, combination chemotherapy (with and without L-asparaginase), and on completion of therapy. The clinical significance of the altered lipid profiles and comparison with lipid profiles observed in children with other forms of cancer are presented.

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      Peritoneal metastases in children with cancer (pages 385–390)

      Sue C. Kaste, Neyssa Marina, Ray Fryrear, Gary L. Hedlund, Luann Jones, Debbie Poe and Jesse J. Jenkins III

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980715)83:2<385::AID-CNCR25>3.0.CO;2-O

      Peritoneal metastases occur in a wider array of tumors than reported previously, most commonly appear mass-like on computed tomography, and their outcome is not invariably fatal.

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