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Cancer

Cover image for Cancer

1 August 1998

Volume 83, Issue 3

Pages 391–592

  1. Cancer—50 Years Later

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Original Articles
    5. Communications
    6. Correspondence
    7. Errata
    1. You have free access to this content
      Sophisticated techniques detect obscure lymph node metastases in carcinoma of the breast (pages 391–393)

      Armando E. Giuliano and Pond R. Kelemen

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<391::AID-CNCR1>3.0.CO;2-S

      An article by Saphir and Amromin published in Cancer in 1948 reported on the problem of undetected lymph node metastasis from breast carcinoma. This issue still plagues clinicians and is likely to become more controversial with the advent of sophisticated detection techniques. The question still remains: What is the clinical relevance of micrometastases?

  2. Editorials

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Original Articles
    5. Communications
    6. Correspondence
    7. Errata
    1. You have free access to this content
      Detectable tumor cells in the blood and bone marrow : Smoke or fire? (pages 394–398)

      Susan F. Slovin and Howard I. Scher

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<394::AID-CNCR2>3.0.CO;2-P

      Identifying those patients with clinically localized prostate carcinoma who will develop metastatic disease after apparently successful local therapy is an area of active investigation. In this issue of Cancer, Mueller et al. address the critical issue of determining relevant molecular changes in the cells that are isolated from the bone marrow. However, molecular staging, although an outwardly attractive method, has underlying complexities that must be taken into account. See also pages 538-46.

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      Male breast carcinoma : A multiinstitutional challenge (pages 399–400)

      David J. Winchester

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<399::AID-CNCR3>3.0.CO;2-K

      Male breast carcinoma is an uncommon disease entity that requires a multiinstitutional approach to define optimal therapy. See also pages 498-509.

    3. Counterpoint

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      Thyroid carcinoma : Implications of prognostic factors (pages 401–402)

      Ashok R. Shaha

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<401::AID-CNCR4>3.0.CO;2-R

      The outcomes for patients with microcarcinoma of the thyroid gland are excellent, and decisions regarding the extent of treatment should be based on individual, clinical, and pathologic findings and risk-group analysis. See also pages 403-4 and 553-9.

    4. Reply to Counterpoint

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      Thyroid carcinoma : Implications of prognostic factors-reply (pages 403–404)

      Martin Schlumberger

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<403::AID-CNCR5>3.0.CO;2-P

      See also pages 401-2 and 553-9.

  3. Original Articles

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Original Articles
    5. Communications
    6. Correspondence
    7. Errata
    1. Anatomic Site

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      Protease inhibitors and carcinoma of the esophagus (pages 405–408)

      Alastair M. Sammon

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<405::AID-CNCR6>3.0.CO;2-N

      A case-control study in an area in which esophageal carcinoma is endemic found a significant association between carcinoma of the esophagus and foods containing protease inhibitors. Unopposed action of growth factors in the esophagus may predispose certain individuals to carcinogenesis.

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      Neutropenic enterocolitis as a complication of high dose chemotherapy with stem cell rescue in patients with solid tumors : A case series with a review of the literature (pages 409–414)

      David Avigan, Paul Richardson, Anthony Elias, George Demetri, Michael Shapiro, Lowell Schnipper and Catherine Wheeler

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<409::AID-CNCR7>3.0.CO;2-J

      Neutropenic enterocolitis was first described as a complication of high dose chemotherapy with stem cell rescue in patients with solid tumors. A review of the literature with emphasis on the issues regarding surgical versus medical management is provided.

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      Intratumor distribution of 1p deletions in human colorectal adenocarcinoma is Commonly homogeneous : Indirect evidence of early involvement in colorectal tumorigenesis (pages 415–422)

      Angela Di Vinci, Edmondo Infusini, Stefano Nigro, Roberto Monaco and Walter Giaretti

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<415::AID-CNCR8>3.0.CO;2-N

      Intratumor fluorescence in situ hybridization interphase cytogenetics indicates that 1p deletions in colorectal adenocarcinomas are common and that they are homogeneously distributed (indicative of an early event) in the vast majority of cases.

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      Gallbladder carcinoma discovered during laparoscopic cholecystectomy : Aggressive reresection is beneficial (pages 423–427)

      Yuman Fong, Nancy Heffernan and Leslie H. Blumgart

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<423::AID-CNCR9>3.0.CO;2-P

      Increasing numbers of laparoscopically discovered gallbladder carcinomas are encountered as laparoscopic procedures become more popular. Radical surgical treatment is safe and beneficial for patients with laparoscopically discovered gallbladder carcinoma.

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      Enteropancreatic malignancy associated with multiple endocrine neoplasia type 1 : Risk factors and pathogenesis (pages 428–434)

      John R. Burgess, Tim M. Greenaway, Venkateswaran Parameswaran, David R. Challis, Rueben David and Joseph J. Shepherd

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<428::AID-CNCR10>3.0.CO;2-Y

      Hypergastrinemia, advancing patient age, and a family history of enteropancreatic malignancy are associated with an increased risk of enteropancreatic malignancy for patients with multiple endocrine neoplasia type 1 (MEN 1). Heritable disease modifier factor(s) for enteropancreatic malignancy appear to reside at loci distinct from that of the MEN 1 gene.

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      Neuroendocrine differentiation in human gastric carcinoma (pages 435–444)

      Helge L. Waldum, Steinar Aase, Igor Kvetnoi, Eiliv Brenna, Arne K. Sandvik, Unni Syversen, Gjermund Johnsen, Lars Vatten and Julia M. Polak

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<435::AID-CNCR11>3.0.CO;2-X

      In the current study neuroendocrine and particularly enterochromaffin-like cell differentiation in gastric carcinoma has been assessed by multiple methods and techniques. It is concluded that at least 10% of gastric carcinomas previously classified as adenocarcinomas actually are malignant neuroendocrine tumors.

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      Serum progesterone levels in patients with gastric adenocarcinoma before and after gastrectomy (pages 445–448)

      Chew-Wun Wu, Chin-Wen Chi, Mao-Chih Hsieh, Su-Shun Lo, King-Han Shen, Wing-Yiu Lui and Fang-Ku P'eng

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<445::AID-CNCR12>3.0.CO;2-W

      By an unknown mechanism, serum progesterone level reflects the presence or absence of gastric adenocarcinoma.

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      Primary non-hodgkin's lymphoma of the nasal cavity : Prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy (pages 449–456)

      Ye-Xiong Li, Philippe A. Coucke, Jian-Ying Li, Da-Zhong Gu, Xin-Fan Liu, Li-Qiang Zhou, René-Olivier Mirimanoff, Zi-Hao Yu and Yi-Rong Huang

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<449::AID-CNCR13>3.0.CO;2-W

      Paranasal extension is a significant prognostic factor in patients with Ann Arbor Stage IE non-Hodgkin's lymphoma of the nasal cavity. Encouraging survival rates have been reported in patients with Stage IE disease limited to the nasal cavity who are treated primarily with radiotherapy. The poor prognosis and extranodal progression in patients with extensive Stage IE and Stage IIE-IVE disease illustrate the need for improvement of systemic chemotherapy.

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      Results of treatment of patients with maxillary sinus carcinoma (pages 457–465)

      Arnold C. Paulino, James E. Marks, Preston Bricker, Edward Melian, Sarada P. Reddy and Bahman Emami

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<457::AID-CNCR14>3.0.CO;2-V

      Patients who underwent surgery and radiation therapy had a better disease free survival and local control rate than those who received radiation therapy alone. Local failure appears to be the main problem in the treatment of maxillary sinus carcinoma.

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      KAI1/CD82 expression in nonsmall cell lung carcinoma is a novel, favorable prognostic factor : An immunohistochemical analysis (pages 466–474)

      Masahiko Higashiyama, Ken Kodama, Hideoki Yokouchi, Koji Takami, Masashi Adachi, Toshihiko Taki, Shingo Ishiguro, Shoji Nakamori, Osamu Yoshie and Masayuki Miyake

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<466::AID-CNCR15>3.0.CO;2-U

      In patients with nonsmall cell lung carcinoma, particularly adenocarcinoma, who undergo potentially curative surgery, the immunohistochemically determined level of KAI1/CD82 expression may be a favorable prognostic factor for postoperative overall survival as well as disease free survival.

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      Relation between microsatellite instability and N-ras mutation and duration of disease free survival in patients with acute leukemia (pages 475–481)

      Sakae Tanosaki, Koiti Inokuchi, Takashi Shimada and Kazuo Dan

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<475::AID-CNCR16>3.0.CO;2-T

      This study demonstrates that microsatellite instability may be associated with N-ras mutation in some cases of de novo acute leukemia (P < 0.003) and may influence the duration of disease free survival (P < 0.03).

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      Neurotoxicity of interferon-α in melanoma therapy : Results from a randomized controlled trial (pages 482–489)

      Augusto Caraceni, Laura Gangeri, Cinzia Martini, Filiberto Belli, Cinzia Brunelli, Maria Baldini, Luigi Mascheroni, Leonardo Lenisa and Natale Cascinelli

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<482::AID-CNCR17>3.0.CO;2-S

      Using a randomized, controlled clinical trial and within blinded assessment conditions, this study found that low dose, adjuvant interferon-α immunotherapy for malignant melanoma produces mild neurologic side effects, mainly action tremor, and has no significant impact on quality of life measures.

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      Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma (pages 490–497)

      Martin J. Heslin, Carlos Cordon-Cardo, Jonathan J. Lewis, James M. Woodruff and Murray F. Brennan

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<490::AID-CNCR18>3.0.CO;2-R

      In addition to standard preoperative criteria, Ki-67 score is an independent prognostic molecular marker that predicts distant metastasis and tumor mortality in patients with high grade extremity soft tissue sarcoma. As preoperative investigational treatment remains controversial, the selection of candidates may be further refined according to Ki-67 expression in addition to high grade and large tumor size.

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      Carcinoma of the breast in males : A multiinstitutional survey (pages 498–509)

      William L. Donegan, Philip N. Redlich, Peter J. Lang and Matthew T. Gall

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<498::AID-CNCR19>3.0.CO;2-R

      A review of 217 cases of male breast carcinoma accrued from 18 hospitals in Wisconsin indicates that the overall prognosis of this disease is improving concurrent with the use of less extensive surgery and systemic adjuvant therapy.

      See also pages 399-400.

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      The rectus abdominis myocutaneous flap : Modifications, complications, and sexual Function (pages 510–520)

      Harriet O. Smith, Mark C. Genesen, Carolyn D. Runowicz and Gary L. Goldberg

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<510::AID-CNCR20>3.0.CO;2-Y

      The rectus abdominis myocutaneous flap is a safe alternative to vaginal reconstruction after pelvic exenteration, and in this study it preserved sexual function in the majority of patients who were clinically free of disease.

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      Human papillomavirus type 16 is Detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium (pages 521–527)

      Ruth A. Lininger, Ignacio Wistuba, Adi Gazdar, Christopher Koenig, Fattaneh A. Tavassoli and Jorge Albores-Saavedra

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<521::AID-CNCR21>3.0.CO;2-X

      In this study, human papillomavirus type 16 was detected by PCR in 4 of 6 transitional cell carcinomas (TCCs) of the cervix and in 2 of 8 TCCs of the endometrium.

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      Fatty acid synthase expression in endometrial carcinoma : Correlation with cell proliferation and hormone receptors (pages 528–537)

      Ellen S. Pizer, Sigurd F. Lax, Francis P. Kuhajda, Gary R. Pasternack and Robert J. Kurman

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<528::AID-CNCR22>3.0.CO;2-X

      In this study, fatty acid synthase enzyme expression, a marker of poor prognosis in breast and prostate carcinoma, is correlated with tumor grade and cellular proliferation in endometrial carcinoma.

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      Low frequency epithelial cells in bone marrow aspirates from prostate carcinoma patients are cytogenetically aberrant (pages 538–546)

      Peter Mueller, Peter Carroll, Erin Bowers, Dan Moore II, Michael Cher, Joseph Presti, Maija Wessman and Maria G. Pallavicini

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<538::AID-CNCR23>3.0.CO;2-W

      Low frequency micrometastatic epithelial cells in bone marrow aspirates from patients with prostate carcinoma are aneusomic. See also pages 394-8.

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      Bilateral testicular tumors : Management and outcome in 21 patients (pages 547–552)

      Christopher L. Coogan, Richard S. Foster, Garrick R. Simmons, Piero G. Tognoni, Bruce J. Roth and John P. Donohue

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<547::AID-CNCR24>3.0.CO;2-V

      The treatment of patients with bilateral germ cell tumors is based on the pathology and clinical stage and is not different from patients with unilateral tumors. Patients with testicular carcinoma should be informed of the necessity of long term follow-up.

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      Microcarcinoma of the thyroid gland : The Gustave-Roussy Institute experience (pages 553–559)

      Eric Baudin, Jean P. Travagli, Jacques Ropers, Francesco Mancusi, Gabriella Bruno-Bossio, Bernard Caillou, Anne F. Cailleux, Jean D. Lumbroso, Claude Parmentier and Martin Schlumberger

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<553::AID-CNCR25>3.0.CO;2-U

      The recurrence rate for thyroid microcarcinoma (TMC) is low (3.9%). Two independent risk factors of relapse have been identified, namely, multifocality and the extent of thyroid surgery. In the authors' view, loboisthmusectomy is the treatment of choice for patients with TMC when only one focus of cancer is found histologically, and total thyroidectomy is the optimal treatment for patients with multiple foci. See also pages 401-2 and 403-4.

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      Favorable prognosis after late relapse of hodgkin's disease (pages 560–565)

      R. Garcia-Carbonero, L. Paz-Ares, A. Arcediano, J. Lahuerta, A. Bartolome and H. Cortes-Funes

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<560::AID-CNCR26>3.0.CO;2-T

      The actual incidence of late relapse (13.4% relapse rate at 15 years) emphasizes the need for continuous follow-up of patients treated for Hodgkin's disease. Late relapses, if properly managed with conventional therapy, do not compromise survival.

    22. General Topic

      Pediatrics
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      Salvage therapy after postoperative chemotherapy for primary brain tumors in infants and very young children (pages 566–574)

      Paul G. Fisher, Michael N. Needle, Avital Cnaan, Huaqing Zhao, J. Russell Geyer, Patricia T. Molloy, Joel W. Goldwein, Alisa B. Herman-Liu and Peter C. Phillips

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<566::AID-CNCR27>3.0.CO;2-T

      A strategy of deferring radiotherapy until relapse for very young children with brain tumors treated with prolonged postoperative chemotherapy demonstrated only limited effectiveness.

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      Pathology review of screening negative neuroblastomas : A report from the Quebec neuroblastoma screening project (pages 575–581)

      Tetsuo Kawakami, Yasumasa Monobe, Hector Monforte, William G. Woods, Mendel Tuchman, Bernard Lemieux, Linda Brisson, Mark Bernstein, Josee Brossard, Jean M. Leclerc, Timothy D. Byrne, Timothy J. Triche and Hiroyuki Shimada

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<575::AID-CNCR28>3.0.CO;2-S

      In this study, mass screening negative neuroblastomas were composed of both histologically favorable and unfavorable tumors. In contrast, mass screening positive and congenital/neonatal cases were predominantly histologically favorable tumors.

  4. Communications

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Original Articles
    5. Communications
    6. Correspondence
    7. Errata
    1. You have free access to this content
      The national cancer data base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma (pages 582–588)

      James E. Marks, Jerri Linn Phillips and Herman R. Menck

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<582::AID-CNCR29>3.0.CO;2-R

      Among 5969 nasopharyngeal carcinoma cases in the U.S., patients of Asian origin had higher percentages of the more radiosensitive nonkeratinizing and undifferentiated carcinomas, and better survival, than patients of other origins who had higher percentages of keratinizing squamous cell carcinoma.

  5. Correspondence

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Original Articles
    5. Communications
    6. Correspondence
    7. Errata
    1. You have free access to this content
      The impact of cancer on the physical function of the elderly and their utilization of health care (pages 589–590)

      Lucia Fratino, Diego Serraino and Vittorina Zagonel

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<589::AID-CNCR30>3.0.CO;2-Q

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      Author reply (pages 590–591)

      Randall S. Stafford and Philip Cyr

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<590::AID-CNCR31>3.0.CO;2-P

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      Cancer among spouses: Review of 195 couples (pages 591–592)

      Trevor W. Beer

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<591::AID-CNCR32>3.0.CO;2-P

  6. Errata

    1. Top of page
    2. Cancer—50 Years Later
    3. Editorials
    4. Original Articles
    5. Communications
    6. Correspondence
    7. Errata
    1. You have free access to this content
      Recombinant interferon-α therapy in patients with follicular lymphoma (pages 0–592)

      H Ozer, PH Wiernik, F Giles and C Tendler

      Article first published online: 9 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19980801)83:3<593::AID-CNCR33>3.0.CO;2-P

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