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Sebaceous gland carcinoma

A subtle second malignancy following radiation therapy in patients with bilateral retinoblastoma

  1. Richard P. Howrey M.D.1,*,
  2. William J. Lipham M.D.2,
  3. William H. Schultz M.H.S., PA-C.1,
  4. Edward G. Buckley M.D.1,2,
  5. Jonathan J. Dutton M.D., Ph.D.2,
  6. Gordon K. Klintworth M.D., Ph.D.2,3,
  7. Philip M. Rosoff M.D.1

Article first published online: 9 NOV 2000

DOI: 10.1002/(SICI)1097-0142(19980815)83:4<767::AID-CNCR20>3.0.CO;2-P

Issue

Cancer

Cancer

Volume 83, Issue 4, pages 767–771, 15 August 1998

Additional Information

How to Cite

Howrey, R. P., Lipham, W. J., Schultz, W. H., Buckley, E. G., Dutton, J. J., Klintworth, G. K. and Rosoff, P. M. (1998), Sebaceous gland carcinoma. Cancer, 83: 767–771. doi: 10.1002/(SICI)1097-0142(19980815)83:4<767::AID-CNCR20>3.0.CO;2-P

Author Information

  1. 1

    Division of Pediatric Hematology Oncology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina

  2. 2

    Department of Ophthalmology, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina

  3. 3

    Department of Pathology, Department of Pathology, Duke University Medical Center, Durham, North Carolina

*Division of Pediatric Hematology-Oncology, Box 2916, Duke University Medical Center, Durham, NC 27710

Publication History

  1. Issue published online: 9 NOV 2000
  2. Article first published online: 9 NOV 2000
  3. Manuscript Accepted: 4 FEB 1998
  4. Manuscript Received: 27 JAN 1998

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Keywords:

  • retinoblastoma;
  • sebaceous gland carcinoma;
  • radiation;
  • second primary neoplasms

Sebaceous gland carcinoma can occur in survivors of retinoblastoma, especially following radiation therapy. The poor prognosis associated with delayed diagnosis makes the recognition of this association important.

Abstract

BACKGROUND

Second primary malignancies are common after bilateral retinoblastoma; their estimated incidence has been as high as 51% 50 years after diagnosis. Fifteen patients who developed sebaceous gland carcinoma after radiation therapy have been reported in the literature, five of whom were treated for bilateral retinoblastoma.

METHODS

The authors conducted a retrospective chart review of patients treated for bilateral retinoblastoma at Duke University Medical Center who later developed sebaceous gland carcinoma.

RESULTS

This article reports two patients who developed sebaceous gland carcinoma after radiation therapy for bilateral retinoblastoma.

CONCLUSIONS

Delay in diagnosis is often associated with sebaceous gland carcinoma. Because high mortality is observed with metastatic disease, the recognition of this association is important for anyone who follows patients with a history of bilateral retinoblastoma or prior cranial radiation therapy. Cancer 1998;83:767-771. © 1998 American Cancer Society.

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